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TFPI2 tissue factor pathway inhibitor 2 [ Homo sapiens (human) ]

Gene ID: 7980, updated on 21-Apr-2019

Summary

Official Symbol
TFPI2provided by HGNC
Official Full Name
tissue factor pathway inhibitor 2provided by HGNC
Primary source
HGNC:HGNC:11761
See related
Ensembl:ENSG00000105825 MIM:600033
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP5; REF1; TFPI-2
Summary
This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Expression
Biased expression in placenta (RPKM 566.0) and fat (RPKM 18.9) See more
Orthologs

Genomic context

See TFPI2 in Genome Data Viewer
Location:
7q21.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (93885397..93890991, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (93514709..93520303, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene microRNA 4652 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4 pseudogene 2 Neighboring gene uncharacterized LOC105375401 Neighboring gene uncharacterized LOC105375402 Neighboring gene G protein subunit gamma transducin 1 Neighboring gene G protein subunit gamma 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tissue factor pathway inhibitor 2 (TFPI2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of tissue factor pathway inhibitor 2 (TFPI2) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21164

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix structural constituent TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
cellular response to fluid shear stress IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular matrix TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
tissue factor pathway inhibitor 2
Names
placental protein 5
retinal pigment epithelium cell factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032914.1 RefSeqGene

    Range
    5001..10595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001271003.1NP_001257932.1  tissue factor pathway inhibitor 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001257932.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK092499, AK129833, DA831865
    UniProtKB/Swiss-Prot
    P48307
    Conserved Domains (2) summary
    cd00109
    Location:2675
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:146193
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  2. NM_001271004.1NP_001257933.1  tissue factor pathway inhibitor 2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001257933.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK129833, DA831865, DA833200
    Conserved Domains (2) summary
    cd00109
    Location:3486
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:95149
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  3. NM_006528.4NP_006519.1  tissue factor pathway inhibitor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006519.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC002076, AK129833
    Consensus CDS
    CCDS5632.1
    UniProtKB/Swiss-Prot
    P48307
    Related
    ENSP00000222543.5, ENST00000222543.11
    Conserved Domains (2) summary
    cd00109
    Location:3486
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:157204
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    93885397..93890991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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