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ADIPOR2 adiponectin receptor 2 [ Homo sapiens (human) ]

Gene ID: 79602, updated on 21-Apr-2019

Summary

Official Symbol
ADIPOR2provided by HGNC
Official Full Name
adiponectin receptor 2provided by HGNC
Primary source
HGNC:HGNC:24041
See related
Ensembl:ENSG00000006831 MIM:607946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAQR2; ACDCR2
Summary
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in fat (RPKM 49.9), adrenal (RPKM 34.9) and 25 other tissues See more
Orthologs

Genomic context

See ADIPOR2 in Genome Data Viewer
Location:
12p13.33
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (1691027..1788679)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (1800147..1897845)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Wnt family member 5B Neighboring gene F-box and leucine rich repeat protein 14 Neighboring gene microRNA 3649 Neighboring gene SDA1 domain containing 1 pseudogene Neighboring gene ribosomal protein S4X pseudogene 14 Neighboring gene uncharacterized LOC105369602 Neighboring gene uncharacterized LOC105369601 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.
NHGRI GWA Catalog

Pathways from BioSystems

  • AMP-activated Protein Kinase (AMPK) Signaling, organism-specific biosystem (from WikiPathways)
    AMP-activated Protein Kinase (AMPK) Signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
  • AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem (from REACTOME)
    AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystemAMP-activated protein kinase (AMPK) is a sensor of cellular energy levels. A high cellular ratio of AMP:ATP triggers the phosphorylation and activation of AMPK. Activated AMPK in turn phosphorylates ...
  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
    Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
    Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
    Integration of energy metabolism, organism-specific biosystemMany hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insul...
  • Longevity regulating pathway, organism-specific biosystem (from KEGG)
    Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4640, FLJ21432

Gene Ontology Provided by GOA

Function Evidence Code Pubs
adipokinetic hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
adiponectin binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adiponectin-activated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
hormone-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
regulation of fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
vascular wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
adiponectin receptor protein 2
Names
progestin and adipoQ receptor family member 2
progestin and adipoQ receptor family member II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024551.3NP_078827.2  adiponectin receptor protein 2

    See identical proteins and their annotated locations for NP_078827.2

    Status: VALIDATED

    Source sequence(s)
    AC005183, AC005343
    Consensus CDS
    CCDS8511.1
    UniProtKB/Swiss-Prot
    Q86V24
    Related
    ENSP00000349616.4, ENST00000357103.5
    Conserved Domains (1) summary
    pfam03006
    Location:140363
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    1691027..1788679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253789.2XP_005253846.1  adiponectin receptor protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005253846.1

    UniProtKB/Swiss-Prot
    Q86V24
    Conserved Domains (1) summary
    pfam03006
    Location:140363
    HlyIII; Haemolysin-III related
  2. XM_006719018.2XP_006719081.1  adiponectin receptor protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006719081.1

    UniProtKB/Swiss-Prot
    Q86V24
    Conserved Domains (1) summary
    pfam03006
    Location:140363
    HlyIII; Haemolysin-III related
  3. XM_011521024.2XP_011519326.1  adiponectin receptor protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011519326.1

    UniProtKB/Swiss-Prot
    Q86V24
    Conserved Domains (1) summary
    pfam03006
    Location:140363
    HlyIII; Haemolysin-III related

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_018654718.1 Reference GRCh38.p12 PATCHES

    Range
    33225..130823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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