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ZYX zyxin [ Homo sapiens (human) ]

Gene ID: 7791, updated on 15-Apr-2019

Summary

Official Symbol
ZYXprovided by HGNC
Official Full Name
zyxinprovided by HGNC
Primary source
HGNC:HGNC:13200
See related
Ensembl:ENSG00000159840 MIM:602002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESP-2; HED-2
Summary
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 122.6), lung (RPKM 100.3) and 25 other tissues See more
Orthologs

Genomic context

See ZYX in Genome Data Viewer
Location:
7q34
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (143381227..143391111)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143078338..143088204)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928397 Neighboring gene family with sequence similarity 131 member B Neighboring gene uncharacterized LOC100507507 Neighboring gene microRNA 6892 Neighboring gene EPH receptor A1 Neighboring gene EPHA1 antisense RNA 1 Neighboring gene taste 2 receptor member 62 pseudogene Neighboring gene taste 2 receptor member 60

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zyxin (ZYX) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Yeast two hybrid assay identifies the HIV-1 Nef-interacting protein zyxin. HIV-1 Nef co-localizes with zyxin in the cortical regions of human podocyte PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • E-cadherin signaling in keratinocytes, organism-specific biosystem (from Pathway Interaction Database)
    E-cadherin signaling in keratinocytes, organism-specific biosystem
    E-cadherin signaling in keratinocytes
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
  • Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
    Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
    Stabilization and expansion of the E-cadherin adherens junction

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cell-matrix adhesion IC
Inferred by Curator
more info
PubMed 
cellular response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell-cell adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
focal adhesion HDA PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010972.1NP_001010972.1  zyxin isoform 1

    See identical proteins and their annotated locations for NP_001010972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC008743, BC009360, BC017183, BU844538
    Consensus CDS
    CCDS5883.1
    UniProtKB/Swiss-Prot
    Q15942
    UniProtKB/TrEMBL
    Q96AF9
    Conserved Domains (4) summary
    cd09349
    Location:351437
    LIM1_Zyxin; The first LIM domain of Zyxin
    cd09435
    Location:504570
    LIM3_Zyxin; The third LIM domain of Zyxin
    cl02475
    Location:444503
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl25764
    Location:201365
    PAT1; Topoisomerase II-associated protein PAT1
  2. NM_001362783.1NP_001349712.1  zyxin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK298925, BC008743, BM857080
    Conserved Domains (3) summary
    cd09435
    Location:473539
    LIM3_Zyxin; The third LIM domain of Zyxin
    cl02475
    Location:320406
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl25764
    Location:170334
    PAT1; Topoisomerase II-associated protein PAT1
  3. NM_003461.5NP_003452.1  zyxin isoform 1

    See identical proteins and their annotated locations for NP_003452.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC008743
    Consensus CDS
    CCDS5883.1
    UniProtKB/Swiss-Prot
    Q15942
    UniProtKB/TrEMBL
    Q96AF9
    Related
    ENSP00000324422.5, ENST00000322764.10
    Conserved Domains (4) summary
    cd09349
    Location:351437
    LIM1_Zyxin; The first LIM domain of Zyxin
    cd09435
    Location:504570
    LIM3_Zyxin; The third LIM domain of Zyxin
    cl02475
    Location:444503
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl25764
    Location:201365
    PAT1; Topoisomerase II-associated protein PAT1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    143381227..143391111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012587.2XP_016868076.1  zyxin isoform X1

    Conserved Domains (3) summary
    cd09349
    Location:410496
    LIM1_Zyxin; The first LIM domain of Zyxin
    cd09435
    Location:563629
    LIM3_Zyxin; The third LIM domain of Zyxin
    cl02475
    Location:503562
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. XM_011516569.2XP_011514871.2  zyxin isoform X2

    Related
    ENSP00000346417.4, ENST00000354434.8
    Conserved Domains (3) summary
    cd09435
    Location:473539
    LIM3_Zyxin; The third LIM domain of Zyxin
    cl02475
    Location:320406
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl25764
    Location:170334
    PAT1; Topoisomerase II-associated protein PAT1

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_018654714.1 Reference GRCh38.p12 PATCHES

    Range
    631..10475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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