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ZNF207 zinc finger protein 207 [ Homo sapiens (human) ]

Gene ID: 7756, updated on 9-Jun-2025
Official Symbol
ZNF207provided by HGNC
Official Full Name
zinc finger protein 207provided by HGNC
Primary source
HGNC:HGNC:12998
See related
Ensembl:ENSG00000010244 MIM:603428; AllianceGenome:HGNC:12998
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BuGZ; hBuGZ
Summary
Enables microtubule binding activity. Involved in mitotic spindle assembly checkpoint signaling; nuclear chromosome segregation; and protein stabilization. Located in kinetochore; nuclear lumen; and spindle matrix. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in bone marrow (RPKM 30.2), lymph node (RPKM 22.5) and 25 other tissues See more
Orthologs
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See ZNF207 in Genome Data Viewer
Location:
17q11.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (32350157..32381885)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (33295928..33327660)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (30677176..30708904)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene rhomboid like 3 Neighboring gene uncharacterized LOC124903980 Neighboring gene chromosome 17 open reading frame 75 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:30668222-30668404 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:30668873-30669759 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:30673436-30673617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:30679433-30679942 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:30681259-30681760 Neighboring gene MPRA-validated peak2801 silencer Neighboring gene oocyte secreted protein 1 pseudogene 2 Neighboring gene microRNA 632 Neighboring gene nudix hydrolase 15 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:30771309-30771924 Neighboring gene proteasome 26S subunit, non-ATPase 11

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. [Expression of ZNF207 in hepatocellular carcinoma and its significance]. Zhou C, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2019 Apr 28. PMID 31113916
  2. ZNF207, a ubiquitously expressed zinc finger gene on chromosome 6p21.3. Pahl PM, et al. Genomics, 1998 Nov 1. PMID 9799612
  3. A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells. Fang F, et al. Nat Commun, 2018 Oct 22. PMID 30349051, Free PMC Article
  4. BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis. Shirnekhi HK, et al. J Biol Chem, 2020 Oct 23. PMID 32820050, Free PMC Article
  5. System analysis based on the cancer-immunity cycle identifies ZNF207 as a novel immunotherapy target for hepatocellular carcinoma. Wang X, et al. J Immunother Cancer, 2022 Mar. PMID 35246476, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3.
    Title: SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3.
  2. System analysis based on the cancer-immunity cycle identifies ZNF207 as a novel immunotherapy target for hepatocellular carcinoma.
    Title: System analysis based on the cancer-immunity cycle identifies ZNF207 as a novel immunotherapy target for hepatocellular carcinoma.
  3. BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis.
    Title: BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis.
  4. ZNF207 expression is elevated in hepatocellular carcinoma
    Title: [Expression of ZNF207 in hepatocellular carcinoma and its significance].
  5. a distinct isoform of ZNF207 functions in hESCs at the nexus that balances pluripotency and differentiation to ectoderm.
    Title: A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells.
  6. the two zinc fingers of BuGZ directly bind to AurA and BuGZ coacervation appears to promote AurA activation during spindle assembly.
    Title: Aurora A activation in mitosis promoted by BuGZ.
  7. BuGZ forms temperature-dependent liquid droplets alone or on microtubules in physiological buffers. Coacervation in vitro or in spindle and spindle matrix depends on hydrophobic residues in BuGZ. BuGZ coacervation and its binding to microtubules and tubulin are required to promote assembly of spindle and spindle matrix in Xenopus egg extract and in mammalian cells.
    Title: Phase transition of spindle-associated protein regulate spindle apparatus assembly.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp761N202

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule bundle formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic spindle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle matrix IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
BUB3-interacting and GLEBS motif-containing protein ZNF207

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032293.3 → NP_001027464.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform b

    See identical proteins and their annotated locations for NP_001027464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 3. It encodes isoform b, which is shorter than isoform c.
    Source sequence(s)
    AC005899, AI308956, BC002372
    Consensus CDS
    CCDS32614.1
    UniProtKB/TrEMBL
    Q59G94
    Related
    ENSP00000378168.2, ENST00000394673.6
    Conserved Domains (3) summary
    sd00020
    Location:13 → 34
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam06003
    Location:405 → 440
    SMN; Survival motor neuron protein (SMN)
    cd20908
    Location:10 → 90
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  2. NM_001098507.2 → NP_001091977.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform c

    See identical proteins and their annotated locations for NP_001091977.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AC005899, AI308956, AK226172, BC002372
    Consensus CDS
    CCDS42294.1
    UniProtKB/TrEMBL
    Q59G94
    Related
    ENSP00000378165.4, ENST00000394670.9
    Conserved Domains (3) summary
    sd00017
    Location:13 → 32
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam06003
    Location:436 → 471
    SMN; Survival motor neuron protein (SMN)
    cd20908
    Location:10 → 90
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  3. NM_003457.4 → NP_003448.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform a

    See identical proteins and their annotated locations for NP_003448.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an in-frame exon in the coding region, compared to variant 3. It encodes isoform a, which is shorter than isoform c.
    Source sequence(s)
    AC005899, AF046001, AI308956, BC002372
    Consensus CDS
    CCDS11271.1
    UniProtKB/Swiss-Prot
    A8K6Y6, E1P660, E1P661, E1P662, O43670, Q53XS9, Q96HW5, Q9BUQ7
    UniProtKB/TrEMBL
    Q59G94
    Related
    ENSP00000322777.6, ENST00000321233.10
    Conserved Domains (3) summary
    PHA03247
    Location:224 → 436
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:13 → 32
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:10 → 90
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    32350157..32381885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    33295928..33327660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43670.1 GenPept UniProtKB/Swiss-Prot:O43670

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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