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UCP3 uncoupling protein 3 [ Homo sapiens (human) ]

Gene ID: 7352, updated on 12-May-2019

Summary

Official Symbol
UCP3provided by HGNC
Official Full Name
uncoupling protein 3provided by HGNC
Primary source
HGNC:HGNC:12519
See related
Ensembl:ENSG00000175564 MIM:602044
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLC25A9
Summary
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See UCP3 in Genome Data Viewer
Location:
11q13.4
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (74000281..74009237, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73711326..73720282, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene family with sequence similarity 91 member A1 pseudogene Neighboring gene C2 calcium dependent domain containing 3 Neighboring gene protein phosphatase methylesterase 1 Neighboring gene RNA, 5S ribosomal pseudogene 343

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of uncoupling protein 3 (UCP3, mitochondrial, proton carrier) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystem (from WikiPathways)
    Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
  • Electron Transport Chain, organism-specific biosystem (from WikiPathways)
    Electron Transport Chain, organism-specific biosystemAn electron transport chain(ETC) couples a chemical reaction between an electron donor (such as NADH) and an electron acceptor (such as O2) to the transfer of H+ ions across a membrane, through a set...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Mitochondrial Uncoupling Proteins, organism-specific biosystem (from REACTOME)
    Mitochondrial Uncoupling Proteins, organism-specific biosystemUncoupling proteins (UCPs) are members of the mitochondrial transport carrier family, and have been implicated in a wide range of physiological and pathological conditions. Physiological conditions i...
  • Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., organism-specific biosystem (from REACTOME)
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., organism-specific biosystemOxidation of fatty acids and pyruvate in the mitochondrial matrix yield large amounts of NADH. The respiratory electron transport chain couples the re-oxidation of this NADH to NAD+ to the export of ...
  • The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem (from REACTOME)
    The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystemThe metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalen...
  • The fatty acid cycling model, organism-specific biosystem (from REACTOME)
    The fatty acid cycling model, organism-specific biosystemThe "fatty acid cycling" hypothesis proposes that protonated fatty acids flip-flop in the membrane and deliver a proton to the matrix side. UCP1 catalyses the return of the fatty acid anion to the cy...
  • The proton buffering model, organism-specific biosystem (from REACTOME)
    The proton buffering model, organism-specific biosystemThe "proton buffering" model proposes that UCP1 is intrinsically a proton carrier, and that fatty acid acts as a prosthetic group during proton transport. Fatty acid penetrates from the lipid phase, ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
oxidative phosphorylation uncoupler activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adaptive thermogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
mitochondrial transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proton transmembrane transport TAS
Traceable Author Statement
more info
 
respiratory gaseous exchange TAS
Traceable Author Statement
more info
PubMed 
response to activity IEA
Inferred from Electronic Annotation
more info
 
response to cold IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
response to superoxide IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
mitochondrial uncoupling protein 3
Names
solute carrier family 25 member 9
uncoupling protein 3 (mitochondrial, proton carrier)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011515.1 RefSeqGene

    Range
    5001..13957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003356.4NP_003347.1  mitochondrial uncoupling protein 3 isoform UCP3L

    See identical proteins and their annotated locations for NP_003347.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (long) encodes the full length isoform.
    Source sequence(s)
    AP003717, AW295096, BC008392, BU618868, DA876282, U84763
    Consensus CDS
    CCDS8229.1
    UniProtKB/Swiss-Prot
    P55916
    UniProtKB/TrEMBL
    A0A0S2Z4G5
    Related
    ENSP00000323740.4, ENST00000314032.9
    Conserved Domains (2) summary
    PTZ00169
    Location:14302
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:112210
    Mito_carr; Mitochondrial carrier protein
  2. NM_022803.2NP_073714.1  mitochondrial uncoupling protein 3 isoform UCP3S

    See identical proteins and their annotated locations for NP_073714.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (short) encodes a protein which is different at the C-terminus from isoform UCP3L. It has an incomplete sixth transmembrane domain and an incomplete purine nucleotide binding domain.
    Source sequence(s)
    AP003717, DA876282, U82818
    Consensus CDS
    CCDS44677.1
    UniProtKB/Swiss-Prot
    P55916
    Related
    ENSP00000392143.2, ENST00000426995.2
    Conserved Domains (1) summary
    pfam00153
    Location:112210
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    74000281..74009237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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