TNFRSF1B TNF receptor superfamily member 1B [Homo sapiens (human)] - Gene

Summary

Official Symbol: TNFRSF1Bprovided by HGNC
Official Full Name: TNF receptor superfamily member 1Bprovided by HGNC
Primary source: HGNC:HGNC:11917
See related: Ensembl:ENSG00000028137 MIM:191191; AllianceGenome:HGNC:11917
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
Expression: Broad expression in appendix (RPKM 31.9), spleen (RPKM 25.2) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (12166991..12209220)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (11711114..11753352)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (12227048..12269277)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tumor necrosis factor receptor 2 promotes endothelial cell-mediated suppression of CD8+ T cells through tuning glycolysis in chemoresistance of breast cancer.
Title: Tumor necrosis factor receptor 2 promotes endothelial cell-mediated suppression of CD8+ T cells through tuning glycolysis in chemoresistance of breast cancer.
TNFR2 pathways are fully active in cancer regulatory T cells.
Title: TNFR2 pathways are fully active in cancer regulatory T cells.
Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation.
Title: Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation.
Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B genes with lepromatous leprosy in Western Mexican patients.
Title: Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B genes with lepromatous leprosy in Western Mexican patients.
Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients.
Title: Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients.
Progesterone modulates TNF receptors expression by Jurkat cells cultured with plasma from pregnant women with preeclampsia.
Title: Progesterone modulates TNF receptors expression by Jurkat cells cultured with plasma from pregnant women with preeclampsia.
TNFRSF1B Gene Variants in Clinicopathological Aspects and Prognosis of Patients with Cutaneous Melanoma.
Title: TNFRSF1B Gene Variants in Clinicopathological Aspects and Prognosis of Patients with Cutaneous Melanoma.
Tregs from human blood differentiate into nonlymphoid tissue-resident effector cells upon TNFR2 costimulation.
Title: Tregs from human blood differentiate into nonlymphoid tissue-resident effector cells upon TNFR2 costimulation.
Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion.
Title: Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion.
Knockouts of TNFRSF1A and TNFRSF1B Genes in K562 Cell Line Lead to Diverse Long-Lasting Responses to TNF-alpha.
Title: Knockouts of TNFRSF1A and TNFRSF1B Genes in K562 Cell Line Lead to Diverse Long-Lasting Responses to TNF-α.

Submit: New GeneRIF Correction See all GeneRIFs (374)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interaction	Pubs
HIV/tuberculosis coinfection upregulates TNFRSF1B expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with tuberculosis only)	PubMed

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Apoptosis of CD8+ cells is mediated by the interaction between TNF-alpha bound to the membrane of macrophages (mbTNF) and a receptor on CD8+ T cells (TNF-receptor II, or TNFRII), which is upregulated by treatment with recombinant HIV-1 gp120 or SDF-1	PubMed
	env	HIV-1 gp120 upregulates mu opioid receptor (MOR) expression in TPA-differentiated HL-60 cells; treatment with TNF-alpha neutralizing antibody as well as anti-TNF-alpha receptor type II (TNFR-II) antibody, inhibits gp120-induced upregulation of MOR	PubMed
Nef	nef	Both HIV-1 Nef and Vpu downregulate the cell surface expression of tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B, CD120b)	PubMed
Tat	tat	HIV-1 Tat downregulates the cell surface expression of the p80 form of the tumor necrosis factor receptor (TNFR2)	PubMed
Vpu	vpu	Both HIV-1 Nef and Vpu downregulate the cell surface expression of tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B, CD120b)	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH63769 (e-PCR)
- UniSTS:14599

PMC156606P3 (e-PCR)
- UniSTS:271410

GDB:315093 (e-PCR)
- UniSTS:15167

TNFRSF1B_287 (e-PCR)
- UniSTS:277829

G15915 (e-PCR)
- UniSTS:32079

SHGC-31494 (e-PCR)
- UniSTS:31588

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor activity	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor activity	TAS Traceable Author Statement more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA destabilization	IEA Inferred from Electronic Annotation more info
involved_in aortic valve development	IEA Inferred from Electronic Annotation more info
involved_in aortic valve development	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in glial cell-neuron signaling	IEA Inferred from Electronic Annotation more info
involved_in glial cell-neuron signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle hypertrophy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extracellular matrix constituent secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extracellular matrix constituent secretion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuroinflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuroinflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuroinflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process involved in morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process involved in morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of membrane protein ectodomain proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myelination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of myelination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myelination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of oligodendrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of oligodendrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in pulmonary valve development	IEA Inferred from Electronic Annotation more info
involved_in pulmonary valve development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of T cell cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of T cell cytokine production	IEA Inferred from Electronic Annotation more info
involved_in regulation of T cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytokine production involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokine production involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of myelination	IEA Inferred from Electronic Annotation more info
involved_in regulation of myelination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuroinflammatory response	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuroinflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in specific granule membrane	TAS Traceable Author Statement more info
part_of tumor necrosis factor receptor superfamily complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 1B

Names: TNF-R2; TNF-RII; p75 TNF receptor; p80 TNF-alpha receptor; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; tumor necrosis factor receptor 2; tumor necrosis factor receptor type II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029791.1 RefSeqGene

Range

4989..47218

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001066.3 → NP_001057.1 tumor necrosis factor receptor superfamily member 1B precursor

See identical proteins and their annotated locations for NP_001057.1

Status: REVIEWED

Source sequence(s)

AL031276, AL357835

Consensus CDS

CCDS145.1

UniProtKB/Swiss-Prot

B1AJZ3, P20333, Q16042, Q6YI29, Q9UIH1

UniProtKB/TrEMBL

Q8IVS6

Related

ENSP00000365435.3, ENST00000376259.7

Conserved Domains (1) summary

cd10577
Location:40 → 201

TNFRSF1B; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

12166991..12209220

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011542060.3 → XP_011540362.1 tumor necrosis factor receptor superfamily member 1B isoform X1

UniProtKB/TrEMBL

Q8IVS6

Related

ENSP00000527362.1, ENST00000857303.1

Conserved Domains (1) summary

cd10577
Location:40 → 201

TNFRSF1B; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2
XM_047429422.1 → XP_047285378.1 tumor necrosis factor receptor superfamily member 1B isoform X2

UniProtKB/TrEMBL

Q8IVS6

Related

ENSP00000527363.1, ENST00000857304.1
XM_011542063.3 → XP_011540365.1 tumor necrosis factor receptor superfamily member 1B isoform X4

UniProtKB/TrEMBL

Q8IVS6

Related

ENSP00000527359.1, ENST00000857300.1

Conserved Domains (1) summary

cd10577
Location:40 → 201

TNFRSF1B; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2
XM_047429424.1 → XP_047285380.1 tumor necrosis factor receptor superfamily member 1B isoform X5

UniProtKB/TrEMBL

Q8IVS6
XM_047429423.1 → XP_047285379.1 tumor necrosis factor receptor superfamily member 1B isoform X3

UniProtKB/TrEMBL

Q8IVS6

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

11711114..11753352

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054338566.1 → XP_054194541.1 tumor necrosis factor receptor superfamily member 1B isoform X1

UniProtKB/TrEMBL

Q8IVS6
XM_054338567.1 → XP_054194542.1 tumor necrosis factor receptor superfamily member 1B isoform X2

UniProtKB/TrEMBL

Q8IVS6
XM_054338569.1 → XP_054194544.1 tumor necrosis factor receptor superfamily member 1B isoform X4

UniProtKB/TrEMBL

Q8IVS6
XM_054338568.1 → XP_054194543.1 tumor necrosis factor receptor superfamily member 1B isoform X3

UniProtKB/TrEMBL

Q8IVS6