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TMSB4X thymosin beta 4 X-linked [ Homo sapiens (human) ]

Gene ID: 7114, updated on 21-Apr-2019

Summary

Official Symbol
TMSB4Xprovided by HGNC
Official Full Name
thymosin beta 4 X-linkedprovided by HGNC
Primary source
HGNC:HGNC:11881
See related
Ensembl:ENSG00000205542 MIM:300159
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FX; TB4X; PTMB4; TMSB4
Summary
This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 3301.5), lymph node (RPKM 3201.4) and 24 other tissues See more
Orthologs

Genomic context

See TMSB4X in Genome Data Viewer
Location:
Xp22.2
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (12975107..12977227)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (12993226..12995346)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene toll like receptor 7 Neighboring gene TLR8 antisense RNA 1 Neighboring gene toll like receptor 8 Neighboring gene uncharacterized LOC105373133 Neighboring gene family with sequence similarity 9 member C Neighboring gene uncharacterized LOC105373134

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
actin monomer binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic sequestering of NF-kappaB IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-8 secretion IDA
Inferred from Direct Assay
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of ATP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of endothelial cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of proton-transporting ATP synthase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
PubMed 
regulation of NIK/NF-kappaB signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
sequestering of actin monomers IDA
Inferred from Direct Assay
more info
PubMed 
tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
thymosin beta-4
Names
prothymosin beta-4
t beta-4
thymosin, beta 4, X chromosome

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021109.4NP_066932.1  thymosin beta-4

    See identical proteins and their annotated locations for NP_066932.1

    Status: REVIEWED

    Source sequence(s)
    AV715954, BC001631
    Consensus CDS
    CCDS35202.1
    UniProtKB/Swiss-Prot
    P62328
    UniProtKB/TrEMBL
    A2VCK8, Q0P5T0
    Related
    ENSP00000414376.2, ENST00000451311.7
    Conserved Domains (1) summary
    pfam01290
    Location:341
    Thymosin; Thymosin beta-4 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    12975107..12977227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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