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TJP1 tight junction protein 1 [ Homo sapiens (human) ]

Gene ID: 7082, updated on 19-Sep-2024

Summary

Official Symbol
TJP1provided by HGNC
Official Full Name
tight junction protein 1provided by HGNC
Primary source
HGNC:HGNC:11827
See related
Ensembl:ENSG00000104067 MIM:601009; AllianceGenome:HGNC:11827
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZO-1
Summary
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in testis (RPKM 23.9), placenta (RPKM 23.2) and 24 other tissues See more
Orthologs
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Genomic context

See TJP1 in Genome Data Viewer
Location:
15q13.1
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (29699367..29969049, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (27490136..27760675, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (29991571..30261252, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene endosomal transmembrane epsin interactor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29967552-29968082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29968083-29968613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:29970293-29970793 Neighboring gene uncharacterized LOC105370743 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:30010173-30011372 Neighboring gene lung cancer immune cell infiltration associated lncRNA Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:30052673-30053872 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 5 Neighboring gene uncharacterized LOC124903451 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:30164609-30165110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:30165111-30165610 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:30171032-30171214 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:30215957-30216506 Neighboring gene Sharpr-MPRA regulatory region 13292 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:30226175-30227374 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:30318078-30318268 Neighboring gene non-SMC condensin I complex subunit G pseudogene 2 Neighboring gene synaptogyrin 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
EBI GWAS Catalog
Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The exposure to HIV-1 or HIV-1 gp120 results in a significant downregulation of tight junction proteins ZO-1, Occludin, Claudin-1, Claudin-2, Claudin-3, Claudin-4, and Claudin-5 in human retinal pigment epithelial cells PubMed
env HIV-1 JRFL and HXB2 Env (gp120) downregulates TJP1(ZO-1) upon interaction with DC-SIGN in ARPE-19 cells and is dependent upon MMP activation PubMed
env HIV-1 gp120-mediated tight junction disruption such as a diffuse cytoplasmic ZO-1 pattern facilitates paracellular penetration of mucosal epithelium by human papillomavirus or herpes simplex virus PubMed
env Treatment of cultured human brain endothelial cells with HIV-1 gp120 results in increased permeability of the endothelial monolayer and causes disruption and downregulation of the tight junction proteins ZO-1, ZO-2, and occludin in these cells PubMed
env The expression of tight junction (TJ) proteins ZO-1, JAM-2, Occludin, Claudin-3 and Claudin-5 is modulated by HIV-1 gp120, and the modulated TJ expression involves Rho-A activation PubMed
env Cannabinoid inhibits HIV-1 gp120-induced tight junction protein down-regulation of ZO-1, claudin-5, and JAM-1 in human brain micro vascular endothelial cells (HBMEC) PubMed
Nef nef Exogenous Nef taken up by Caco-2 cells increases intestinal epithelial permeability, inhibits the IFN-gamma-induced reduction of transepitelial resistance and decreases the tight junction proteins occludin and ZO1 expression PubMed
Tat tat Downregulation of ZO-1 by treatment with HIV-1 Tat and cocaine is inhibited by VEGFR-2 or sigma receptor antagonists, suggesting that VEGFR-2 and sigma receptor are involved in the downregulation of ZO-1 by Tat and cocaine in pulmonary cells PubMed
tat Blocking HIV-1 Tat and cocaine-mediated Erk activation reverses ZO-1 downregulation in human pulmonary artery endothelial cells PubMed
tat HIV-1 Tat-mediated tight junction disruption such as a diffuse cytoplasmic ZO-1 pattern facilitates paracellular penetration of mucosal epithelium by human herpes simplex virus PubMed
tat The function and activity of CREB is required for both Tat-induced Rho signaling and nuclear targeting of ZO-1 PubMed
tat Treatment of a brain endothelial cell line with HIV-1 Tat results in a decrease in total levels of ZO-1 but significantly upregulate ZO-1 protein expression in the nuclei PubMed
tat Exposure to Tat diminishes the expression of several tight junction proteins, including occludin, zonula occludens (ZO)-1, and ZO-2 in the caveolar fraction of human brain micro vascular endothelial cells PubMed
tat HIV-1 Tat-mediated tight junction disruption such as a diffuse cytoplasmic ZO-1 pattern facilitates paracellular penetration of mucosal epithelium by human papillomavirus PubMed
tat HIV-1 Tat B disrupts blood-brain barrier (BBB) integrity to a greater extent compared to HIV-1 Tat C. This BBB dysfunction is associated with modulated expression of tight junction proteins zona occuldens (ZO-1) and junctional adhesion molecule (JAM)-2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC133289, DKFZp686M05161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actomyosin structure organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adherens junction maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ameloblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell junction assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in cell-cell junction organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell junction organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of endothelial intestinal barrier IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of blood-brain barrier permeability IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of blood-brain barrier permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell-cell adhesion mediated by cadherin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to adherens junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to bicellular tight junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to cell-cell junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of bicellular tight junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in adherens junction TAS
Traceable Author Statement
more info
PubMed 
located_in apical junction complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction TAS
Traceable Author Statement
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in gap junction ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in podosome IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in tight junction IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
tight junction protein ZO-1
Names
zona occludens 1
zonula occludens 1 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301025.3NP_001287954.2  tight junction protein ZO-1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, and it uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is longer than isoform a. The exon combination of this variant is inferred based on partial transcript alignments.
    Source sequence(s)
    AC022613, AC087455, AF035298
    Consensus CDS
    CCDS91971.1
    UniProtKB/TrEMBL
    A9CQZ8, G3V1L9
    Related
    ENSP00000348416.7, ENST00000356107.11
    Conserved Domains (8) summary
    cd12026
    Location:610674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:115200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518594
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:17281827
    ZU5; ZU5 domain
    cl27975
    Location:9471342
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    cl28087
    Location:12281688
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  2. NM_001301026.2NP_001287955.1  tight junction protein ZO-1 isoform d

    See identical proteins and their annotated locations for NP_001287955.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, and it lacks an alternate in-frame exon in the central coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AB370197, AC022613, AF035298, BX640879
    Consensus CDS
    CCDS73702.1
    UniProtKB/TrEMBL
    G5E9E7, Q6MZU1
    Related
    ENSP00000382890.2, ENST00000400011.6
    Conserved Domains (7) summary
    cd12026
    Location:521585
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:619798
    GuKc; Guanylate kinase homologues
    smart00228
    Location:187267
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:26111
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:429505
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:15581656
    ZU5; ZU5 domain
    pfam07223
    Location:8691174
    DUF1421; Protein of unknown function (DUF1421)
  3. NM_001330239.4NP_001317168.1  tight junction protein ZO-1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (e) is longer than isoform a.
    Source sequence(s)
    AC022613
    Consensus CDS
    CCDS81858.1
    UniProtKB/TrEMBL
    A0A087X0K9, A9CQZ8
    Related
    ENSP00000483470.2, ENST00000614355.5
    Conserved Domains (7) summary
    cd12026
    Location:517581
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:615794
    GuKc; Guanylate kinase homologues
    smart00228
    Location:183263
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:22107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:425501
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:16341732
    ZU5; ZU5 domain
    pfam07223
    Location:9221250
    DUF1421; Protein of unknown function (DUF1421)
  4. NM_001355012.2NP_001341941.1  tight junction protein ZO-1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AA101028, AC022613, AC087455, AF035298, AL707462, BC111712, BE082525, BE819398, BI914113, BM459712, BQ434619, BQ575449, BX504167, BX640879, CD653673, CN372462, CN372473, CV571135, DB089107, HY197781
    UniProtKB/TrEMBL
    A9CQZ8
    Conserved Domains (8) summary
    smart00218
    Location:17251831
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd12026
    Location:610674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:115200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518594
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl27975
    Location:9471342
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    cl28087
    Location:12281688
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  5. NM_001355013.1NP_001341942.1  tight junction protein ZO-1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC022613, AF035298, BC111712, BU618228, BX640879
    UniProtKB/TrEMBL
    A9CQZ8
    Conserved Domains (8) summary
    cd12026
    Location:521585
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:619798
    GuKc; Guanylate kinase homologues
    smart00228
    Location:187267
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:26111
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:429505
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:16391728
    ZU5; ZU5 domain
    cl27975
    Location:8581253
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    cl28087
    Location:11391599
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  6. NM_001355014.2NP_001341943.1  tight junction protein ZO-1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC022613, AF035298, BC111712, BU618228, BX640879, L14837
    UniProtKB/TrEMBL
    A9CQZ8
    Conserved Domains (8) summary
    cd12026
    Location:517581
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:615794
    GuKc; Guanylate kinase homologues
    smart00228
    Location:183263
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:22107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:425501
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:16351724
    ZU5; ZU5 domain
    cl27975
    Location:8541249
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    cl28087
    Location:11351595
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  7. NM_001355015.2NP_001341944.1  tight junction protein ZO-1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC022613, AF035298, AK302971, BC111712, BM722482, BX640879, L14837
    Consensus CDS
    CCDS91970.1
    UniProtKB/TrEMBL
    A0A7I2V5U5, Q6MZU1
    Related
    ENSP00000504775.1, ENST00000677774.1
    Conserved Domains (7) summary
    cd12026
    Location:517581
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:615794
    GuKc; Guanylate kinase homologues
    smart00228
    Location:183263
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:22107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:425501
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:15551654
    ZU5; ZU5 domain
    cl28087
    Location:10551515
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  8. NM_003257.5NP_003248.3  tight junction protein ZO-1 isoform a

    See identical proteins and their annotated locations for NP_003248.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as ZO-1alpha+) encodes isoform a, which is found in most epithelial cell junctions.
    Source sequence(s)
    AC022613, AF035298, BC111712, BX640879, L14837
    Consensus CDS
    CCDS42007.1
    UniProtKB/Swiss-Prot
    B4E3K1, Q07157, Q2NKP3, Q4ZGJ6
    UniProtKB/TrEMBL
    A9CQZ8
    Related
    ENSP00000281537.7, ENST00000346128.10
    Conserved Domains (7) summary
    smart00218
    Location:16321738
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd12026
    Location:517581
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:615794
    GuKc; Guanylate kinase homologues
    smart00228
    Location:183263
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:22107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:425501
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam07223
    Location:9221250
    DUF1421; Protein of unknown function (DUF1421)
  9. NM_175610.4NP_783297.2  tight junction protein ZO-1 isoform b

    See identical proteins and their annotated locations for NP_783297.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as ZO-1alpha-) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. Isoform b is found in both endothelial cells and the highly specialized epithelial junctions of renal glomeruli and sertoli cells of the seminiferous tubules. The exon combination of this variant is inferred based on partial transcript alignments and data in PMID:1590354.
    Source sequence(s)
    AC022613, AF035298, AK302971, BC111712, BX640879, L14837
    Consensus CDS
    CCDS45199.1
    UniProtKB/TrEMBL
    Q6MZU1
    Related
    ENSP00000441202.2, ENST00000545208.6
    Conserved Domains (7) summary
    smart00218
    Location:15521658
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd12026
    Location:517581
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:615794
    GuKc; Guanylate kinase homologues
    smart00228
    Location:183263
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:22107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:425501
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam07223
    Location:8651170
    DUF1421; Protein of unknown function (DUF1421)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    29699367..29969049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254620.4XP_005254677.2  tight junction protein ZO-1 isoform X14

    UniProtKB/TrEMBL
    Q6MZU1
    Conserved Domains (6) summary
    smart00218
    Location:16451751
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd12026
    Location:610674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK10263
    Location:11481608
    PRK10263; DNA translocase FtsK; Provisional
    cd00992
    Location:115200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_047432984.1XP_047288940.1  tight junction protein ZO-1 isoform X13

    UniProtKB/TrEMBL
    Q6MZU1
  3. XM_005254619.4XP_005254676.2  tight junction protein ZO-1 isoform X9

    UniProtKB/TrEMBL
    Q6MZU1
  4. XM_047432981.1XP_047288937.1  tight junction protein ZO-1 isoform X10

    UniProtKB/TrEMBL
    Q6MZU1
  5. XM_017022524.2XP_016878013.1  tight junction protein ZO-1 isoform X5

    UniProtKB/TrEMBL
    Q6MZU1
  6. XM_011521972.3XP_011520274.2  tight junction protein ZO-1 isoform X4

    UniProtKB/TrEMBL
    A9CQZ8
  7. XM_017022523.2XP_016878012.1  tight junction protein ZO-1 isoform X3

    UniProtKB/TrEMBL
    A9CQZ8
  8. XM_017022522.2XP_016878011.1  tight junction protein ZO-1 isoform X2

    UniProtKB/TrEMBL
    A9CQZ8
  9. XM_017022521.2XP_016878010.1  tight junction protein ZO-1 isoform X1

    UniProtKB/TrEMBL
    A9CQZ8
  10. XM_047432990.1XP_047288946.1  tight junction protein ZO-1 isoform X20

    UniProtKB/TrEMBL
    Q6MZU1
  11. XM_047432989.1XP_047288945.1  tight junction protein ZO-1 isoform X19

    UniProtKB/TrEMBL
    Q6MZU1
  12. XM_047432988.1XP_047288944.1  tight junction protein ZO-1 isoform X18

    UniProtKB/TrEMBL
    Q6MZU1
  13. XM_047432986.1XP_047288942.1  tight junction protein ZO-1 isoform X16

    UniProtKB/TrEMBL
    Q6MZU1
  14. XM_047432983.1XP_047288939.1  tight junction protein ZO-1 isoform X12

    UniProtKB/TrEMBL
    A9CQZ8
  15. XM_017022526.2XP_016878015.1  tight junction protein ZO-1 isoform X7

    UniProtKB/TrEMBL
    A9CQZ8
  16. XM_047432987.1XP_047288943.1  tight junction protein ZO-1 isoform X17

    UniProtKB/TrEMBL
    G5E9E7, Q6MZU1
  17. XM_047432985.1XP_047288941.1  tight junction protein ZO-1 isoform X15

    UniProtKB/TrEMBL
    A9CQZ8
  18. XM_017022525.2XP_016878014.1  tight junction protein ZO-1 isoform X6

    UniProtKB/TrEMBL
    A9CQZ8
  19. XM_047432991.1XP_047288947.1  tight junction protein ZO-1 isoform X21

    UniProtKB/TrEMBL
    Q6MZU1
  20. XM_017022527.2XP_016878016.1  tight junction protein ZO-1 isoform X8

    UniProtKB/TrEMBL
    A9CQZ8
  21. XM_047432982.1XP_047288938.1  tight junction protein ZO-1 isoform X11

    UniProtKB/TrEMBL
    A9CQZ8

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_011332701.1 Reference GRCh38.p14 PATCHES

    Range
    1871012..2141730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331832.1XP_054187807.1  tight junction protein ZO-1 isoform X14

    UniProtKB/TrEMBL
    Q6MZU1
  2. XM_054331829.1XP_054187804.1  tight junction protein ZO-1 isoform X13

    UniProtKB/TrEMBL
    Q6MZU1
  3. XM_054331826.1XP_054187801.1  tight junction protein ZO-1 isoform X9

    UniProtKB/TrEMBL
    Q6MZU1
  4. XM_054331827.1XP_054187802.1  tight junction protein ZO-1 isoform X10

    UniProtKB/TrEMBL
    Q6MZU1
  5. XM_054331824.1XP_054187799.1  tight junction protein ZO-1 isoform X22

    UniProtKB/TrEMBL
    Q6MZU1
  6. XM_054331821.1XP_054187796.1  tight junction protein ZO-1 isoform X5

    UniProtKB/TrEMBL
    Q6MZU1
  7. XM_054331820.1XP_054187795.1  tight junction protein ZO-1 isoform X4

    UniProtKB/TrEMBL
    A9CQZ8
  8. XM_054331819.1XP_054187794.1  tight junction protein ZO-1 isoform X3

    UniProtKB/TrEMBL
    A9CQZ8
  9. XM_054331818.1XP_054187793.1  tight junction protein ZO-1 isoform X2

    UniProtKB/TrEMBL
    A9CQZ8
  10. XM_054331817.1XP_054187792.1  tight junction protein ZO-1 isoform X1

    UniProtKB/TrEMBL
    A9CQZ8
  11. XM_054331831.1XP_054187806.1  tight junction protein ZO-1 isoform X24

    UniProtKB/TrEMBL
    A9CQZ8
  12. XM_054331842.1XP_054187817.1  tight junction protein ZO-1 isoform X20

    UniProtKB/TrEMBL
    Q6MZU1
  13. XM_054331840.1XP_054187815.1  tight junction protein ZO-1 isoform X19

    UniProtKB/TrEMBL
    Q6MZU1
  14. XM_054331838.1XP_054187813.1  tight junction protein ZO-1 isoform X18

    UniProtKB/TrEMBL
    Q6MZU1
  15. XM_054331836.1XP_054187811.1  tight junction protein ZO-1 isoform X16

    UniProtKB/TrEMBL
    Q6MZU1
  16. XM_054331823.1XP_054187798.1  tight junction protein ZO-1 isoform X7

    UniProtKB/TrEMBL
    A9CQZ8
  17. XM_054331844.1XP_054187819.1  tight junction protein ZO-1 isoform X30

    UniProtKB/TrEMBL
    Q6MZU1
  18. XM_054331837.1XP_054187812.1  tight junction protein ZO-1 isoform X17

    UniProtKB/TrEMBL
    G5E9E7, Q6MZU1
  19. XM_054331835.1XP_054187810.1  tight junction protein ZO-1 isoform X26

    UniProtKB/TrEMBL
    Q6MZU1
  20. XM_054331833.1XP_054187808.1  tight junction protein ZO-1 isoform X15

    UniProtKB/TrEMBL
    A9CQZ8
  21. XM_054331822.1XP_054187797.1  tight junction protein ZO-1 isoform X6

    UniProtKB/TrEMBL
    A9CQZ8
  22. XM_054331843.1XP_054187818.1  tight junction protein ZO-1 isoform X29

    UniProtKB/TrEMBL
    Q6MZU1
  23. XM_054331839.1XP_054187814.1  tight junction protein ZO-1 isoform X27

    UniProtKB/TrEMBL
    Q6MZU1
  24. XM_054331825.1XP_054187800.1  tight junction protein ZO-1 isoform X8

    UniProtKB/TrEMBL
    A9CQZ8
  25. XM_054331830.1XP_054187805.1  tight junction protein ZO-1 isoform X23

    UniProtKB/TrEMBL
    A9CQZ8
  26. XM_054331845.1XP_054187820.1  tight junction protein ZO-1 isoform X21

    UniProtKB/TrEMBL
    Q6MZU1
  27. XM_054331846.1XP_054187821.1  tight junction protein ZO-1 isoform X31

    UniProtKB/TrEMBL
    Q6MZU1
  28. XM_054331841.1XP_054187816.1  tight junction protein ZO-1 isoform X28

    UniProtKB/TrEMBL
    A0A0G2JNH2, Q6MZU1
  29. XM_054331834.1XP_054187809.1  tight junction protein ZO-1 isoform X25

    UniProtKB/TrEMBL
    A9CQZ8
  30. XM_054331828.1XP_054187803.1  tight junction protein ZO-1 isoform X11

    UniProtKB/TrEMBL
    A9CQZ8

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187660.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    1983496..2254214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330059.1XP_054186034.1  tight junction protein ZO-1 isoform X14

    UniProtKB/TrEMBL
    Q6MZU1
  2. XM_054330056.1XP_054186031.1  tight junction protein ZO-1 isoform X13

    UniProtKB/TrEMBL
    Q6MZU1
  3. XM_054330053.1XP_054186028.1  tight junction protein ZO-1 isoform X9

    UniProtKB/TrEMBL
    Q6MZU1
  4. XM_054330054.1XP_054186029.1  tight junction protein ZO-1 isoform X10

    UniProtKB/TrEMBL
    Q6MZU1
  5. XM_054330051.1XP_054186026.1  tight junction protein ZO-1 isoform X22

    UniProtKB/TrEMBL
    Q6MZU1
  6. XM_054330048.1XP_054186023.1  tight junction protein ZO-1 isoform X5

    UniProtKB/TrEMBL
    Q6MZU1
  7. XM_054330047.1XP_054186022.1  tight junction protein ZO-1 isoform X4

    UniProtKB/TrEMBL
    A9CQZ8
  8. XM_054330046.1XP_054186021.1  tight junction protein ZO-1 isoform X3

    UniProtKB/TrEMBL
    A9CQZ8
  9. XM_054330045.1XP_054186020.1  tight junction protein ZO-1 isoform X2

    UniProtKB/TrEMBL
    A9CQZ8
  10. XM_054330044.1XP_054186019.1  tight junction protein ZO-1 isoform X1

    UniProtKB/TrEMBL
    A9CQZ8
  11. XM_054330058.1XP_054186033.1  tight junction protein ZO-1 isoform X24

    UniProtKB/TrEMBL
    A9CQZ8
  12. XM_054330069.1XP_054186044.1  tight junction protein ZO-1 isoform X20

    UniProtKB/TrEMBL
    Q6MZU1
  13. XM_054330067.1XP_054186042.1  tight junction protein ZO-1 isoform X19

    UniProtKB/TrEMBL
    Q6MZU1
  14. XM_054330065.1XP_054186040.1  tight junction protein ZO-1 isoform X18

    UniProtKB/TrEMBL
    Q6MZU1
  15. XM_054330063.1XP_054186038.1  tight junction protein ZO-1 isoform X16

    UniProtKB/TrEMBL
    Q6MZU1
  16. XM_054330050.1XP_054186025.1  tight junction protein ZO-1 isoform X7

    UniProtKB/TrEMBL
    A9CQZ8
  17. XM_054330071.1XP_054186046.1  tight junction protein ZO-1 isoform X30

    UniProtKB/TrEMBL
    Q6MZU1
  18. XM_054330064.1XP_054186039.1  tight junction protein ZO-1 isoform X17

    UniProtKB/TrEMBL
    G5E9E7, Q6MZU1
  19. XM_054330062.1XP_054186037.1  tight junction protein ZO-1 isoform X26

    UniProtKB/TrEMBL
    Q6MZU1
  20. XM_054330060.1XP_054186035.1  tight junction protein ZO-1 isoform X15

    UniProtKB/TrEMBL
    A9CQZ8
  21. XM_054330049.1XP_054186024.1  tight junction protein ZO-1 isoform X6

    UniProtKB/TrEMBL
    A9CQZ8
  22. XM_054330070.1XP_054186045.1  tight junction protein ZO-1 isoform X29

    UniProtKB/TrEMBL
    Q6MZU1
  23. XM_054330066.1XP_054186041.1  tight junction protein ZO-1 isoform X27

    UniProtKB/TrEMBL
    Q6MZU1
  24. XM_054330052.1XP_054186027.1  tight junction protein ZO-1 isoform X8

    UniProtKB/TrEMBL
    A9CQZ8
  25. XM_054330057.1XP_054186032.1  tight junction protein ZO-1 isoform X23

    UniProtKB/TrEMBL
    A9CQZ8
  26. XM_054330072.1XP_054186047.1  tight junction protein ZO-1 isoform X21

    UniProtKB/TrEMBL
    Q6MZU1
  27. XM_054330073.1XP_054186048.1  tight junction protein ZO-1 isoform X31

    UniProtKB/TrEMBL
    Q6MZU1
  28. XM_054330068.1XP_054186043.1  tight junction protein ZO-1 isoform X28

    UniProtKB/TrEMBL
    A0A0G2JNH2, Q6MZU1
  29. XM_054330061.1XP_054186036.1  tight junction protein ZO-1 isoform X25

    UniProtKB/TrEMBL
    A9CQZ8
  30. XM_054330055.1XP_054186030.1  tight junction protein ZO-1 isoform X11

    UniProtKB/TrEMBL
    A9CQZ8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    27490136..27760675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378703.1XP_054234678.1  tight junction protein ZO-1 isoform X14

    UniProtKB/TrEMBL
    Q6MZU1
  2. XM_054378700.1XP_054234675.1  tight junction protein ZO-1 isoform X13

    UniProtKB/TrEMBL
    Q6MZU1
  3. XM_054378696.1XP_054234671.1  tight junction protein ZO-1 isoform X9

    UniProtKB/TrEMBL
    Q6MZU1
  4. XM_054378697.1XP_054234672.1  tight junction protein ZO-1 isoform X10

    UniProtKB/TrEMBL
    Q6MZU1
  5. XM_054378694.1XP_054234669.1  tight junction protein ZO-1 isoform X32

    UniProtKB/TrEMBL
    Q6MZU1
  6. XM_054378691.1XP_054234666.1  tight junction protein ZO-1 isoform X5

    UniProtKB/TrEMBL
    Q6MZU1
  7. XM_054378690.1XP_054234665.1  tight junction protein ZO-1 isoform X4

    UniProtKB/TrEMBL
    A9CQZ8
  8. XM_054378689.1XP_054234664.1  tight junction protein ZO-1 isoform X3

    UniProtKB/TrEMBL
    A9CQZ8
  9. XM_054378688.1XP_054234663.1  tight junction protein ZO-1 isoform X2

    UniProtKB/TrEMBL
    A9CQZ8
  10. XM_054378687.1XP_054234662.1  tight junction protein ZO-1 isoform X1

    UniProtKB/TrEMBL
    A9CQZ8
  11. XM_054378702.1XP_054234677.1  tight junction protein ZO-1 isoform X34

    UniProtKB/TrEMBL
    A9CQZ8
  12. XM_054378713.1XP_054234688.1  tight junction protein ZO-1 isoform X20

    UniProtKB/TrEMBL
    Q6MZU1
  13. XM_054378711.1XP_054234686.1  tight junction protein ZO-1 isoform X19

    UniProtKB/TrEMBL
    Q6MZU1
  14. XM_054378709.1XP_054234684.1  tight junction protein ZO-1 isoform X18

    UniProtKB/TrEMBL
    Q6MZU1
  15. XM_054378707.1XP_054234682.1  tight junction protein ZO-1 isoform X16

    UniProtKB/TrEMBL
    Q6MZU1
  16. XM_054378699.1XP_054234674.1  tight junction protein ZO-1 isoform X12

    UniProtKB/TrEMBL
    A9CQZ8
  17. XM_054378693.1XP_054234668.1  tight junction protein ZO-1 isoform X7

    UniProtKB/TrEMBL
    A9CQZ8
  18. XM_054378715.1XP_054234690.1  tight junction protein ZO-1 isoform X40

    UniProtKB/TrEMBL
    Q6MZU1
  19. XM_054378708.1XP_054234683.1  tight junction protein ZO-1 isoform X17

    UniProtKB/TrEMBL
    G5E9E7, Q6MZU1
  20. XM_054378706.1XP_054234681.1  tight junction protein ZO-1 isoform X36

    UniProtKB/TrEMBL
    Q6MZU1
  21. XM_054378704.1XP_054234679.1  tight junction protein ZO-1 isoform X15

    UniProtKB/TrEMBL
    A9CQZ8
  22. XM_054378692.1XP_054234667.1  tight junction protein ZO-1 isoform X6

    UniProtKB/TrEMBL
    A9CQZ8
  23. XM_054378716.1XP_054234691.1  tight junction protein ZO-1 isoform X21

    UniProtKB/TrEMBL
    Q6MZU1
  24. XM_054378714.1XP_054234689.1  tight junction protein ZO-1 isoform X39

    UniProtKB/TrEMBL
    Q6MZU1
  25. XM_054378710.1XP_054234685.1  tight junction protein ZO-1 isoform X37

    UniProtKB/TrEMBL
    Q6MZU1
  26. XM_054378695.1XP_054234670.1  tight junction protein ZO-1 isoform X8

    UniProtKB/TrEMBL
    A9CQZ8
  27. XM_054378701.1XP_054234676.1  tight junction protein ZO-1 isoform X33

    UniProtKB/TrEMBL
    A9CQZ8
  28. XM_054378717.1XP_054234692.1  tight junction protein ZO-1 isoform X41

    UniProtKB/TrEMBL
    Q6MZU1
  29. XM_054378712.1XP_054234687.1  tight junction protein ZO-1 isoform X38

    UniProtKB/TrEMBL
    A0A0G2JNH2, Q6MZU1
  30. XM_054378705.1XP_054234680.1  tight junction protein ZO-1 isoform X35

    UniProtKB/TrEMBL
    A9CQZ8
  31. XM_054378698.1XP_054234673.1  tight junction protein ZO-1 isoform X11

    UniProtKB/TrEMBL
    A9CQZ8