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KLF10 KLF transcription factor 10 [ Homo sapiens (human) ]

Gene ID: 7071, updated on 27-Nov-2024

Summary

Official Symbol
KLF10provided by HGNC
Official Full Name
KLF transcription factor 10provided by HGNC
Primary source
HGNC:HGNC:11810
See related
Ensembl:ENSG00000155090 MIM:601878; AllianceGenome:HGNC:11810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EGRA; TIEG; TIEG1; EGR-alpha
Summary
This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in bone marrow (RPKM 49.9), gall bladder (RPKM 37.2) and 25 other tissues See more
Orthologs
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Genomic context

See KLF10 in Genome Data Viewer
Location:
8q22.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (102648784..102655725, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (103777028..103783970, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (103661012..103667953, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27766 Neighboring gene outer dense fiber of sperm tails 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:103595853-103596352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27767 Neighboring gene NANOG hESC enhancer GRCh37_chr8:103602512-103603022 Neighboring gene Sharpr-MPRA regulatory region 4303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27768 Neighboring gene Sharpr-MPRA regulatory region 12948 Neighboring gene POU class 5 homeobox 1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:103646296-103646796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:103646797-103647297 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:103665440-103666064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19442 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:103667983-103668583 Neighboring gene uncharacterized LOC101927245 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:103669184-103669784 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:103669785-103670383 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27770 Neighboring gene uncharacterized LOC105375686 Neighboring gene KLF10-I enhancer Neighboring gene uncharacterized LOC105375685

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of Kruppel-like factor 10 (KLF10) in human B cells PubMed
Tat tat The gene expression of Krueppel-like factor 10 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
Krueppel-like factor 10
Names
Kruppel like factor 10
TGFB-inducible early growth response protein 1
early growth response-alpha
transforming growth factor-beta-inducible early growth response protein 1
zinc finger transcription factor TIEG

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033271.1 RefSeqGene

    Range
    5178..12119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_758

mRNA and Protein(s)

  1. NM_001032282.4NP_001027453.1  Krueppel-like factor 10 isoform b

    See identical proteins and their annotated locations for NP_001027453.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AP002851, BC095399, BQ575313, S81439
    Consensus CDS
    CCDS47905.1
    UniProtKB/Swiss-Prot
    Q13118
    Related
    ENSP00000379222.3, ENST00000395884.3
    Conserved Domains (4) summary
    COG5048
    Location:363413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:363382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:418440
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:404427
    zf-H2C2_2; Zinc-finger double domain
  2. NM_005655.4NP_005646.1  Krueppel-like factor 10 isoform a

    See identical proteins and their annotated locations for NP_005646.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AP002851, BC095399, BQ575313, DA720479
    Consensus CDS
    CCDS6294.1
    UniProtKB/Swiss-Prot
    A8MVH0, B2R794, L0R4P6, L0R679, O75411, Q13118, Q503B2
    Related
    ENSP00000285407.6, ENST00000285407.11
    Conserved Domains (4) summary
    COG5048
    Location:374424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:374393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:429451
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:415438
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_103759.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks the 5' exon and an internal exon, and contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AP002851, BC095399, BQ575313, DA756360, HF546211
  2. NR_103760.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks the 5' exon, contains an alternate 5' exon, and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because use of translational start codon used in variant 2 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP002851, BC095399, BQ575313, DA756360, HF546210

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    102648784..102655725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    103777028..103783970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)