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KLF10 Kruppel like factor 10 [ Homo sapiens (human) ]

Gene ID: 7071, updated on 21-Apr-2019

Summary

Official Symbol
KLF10provided by HGNC
Official Full Name
Kruppel like factor 10provided by HGNC
Primary source
HGNC:HGNC:11810
See related
Ensembl:ENSG00000155090 MIM:601878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EGRA; TIEG; TIEG1; EGR-alpha
Summary
This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in bone marrow (RPKM 49.9), gall bladder (RPKM 37.2) and 25 other tissues See more
Orthologs

Genomic context

See KLF10 in Genome Data Viewer
Location:
8q22.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (102648777..102655902, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (103661005..103668130, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene outer dense fiber of sperm tails 1 Neighboring gene POU class 5 homeobox 1 pseudogene 2 Neighboring gene uncharacterized LOC101927245 Neighboring gene uncharacterized LOC105375686 Neighboring gene uncharacterized LOC105375685

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of Kruppel-like factor 10 (KLF10) in human B cells PubMed
Tat tat The gene expression of Krueppel-like factor 10 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
bone mineralization IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular response to peptide IEA
Inferred from Electronic Annotation
more info
 
cellular response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
Krueppel-like factor 10
Names
TGFB-inducible early growth response protein 1
early growth response-alpha
transforming growth factor-beta-inducible early growth response protein 1
zinc finger transcription factor TIEG

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033271.1 RefSeqGene

    Range
    5001..12126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032282.3NP_001027453.1  Krueppel-like factor 10 isoform b

    See identical proteins and their annotated locations for NP_001027453.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AP002851, BC095399, BQ575313, DA756360, S81439
    Consensus CDS
    CCDS47905.1
    UniProtKB/Swiss-Prot
    Q13118
    Related
    ENSP00000379222.3, ENST00000395884.3
    Conserved Domains (4) summary
    COG5048
    Location:363413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:363382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:418440
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:404427
    zf-H2C2_2; Zinc-finger double domain
  2. NM_005655.4NP_005646.1  Krueppel-like factor 10 isoform a

    See identical proteins and their annotated locations for NP_005646.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AP002851, BC095399, BQ575313, DA720479
    Consensus CDS
    CCDS6294.1
    UniProtKB/Swiss-Prot
    Q13118
    Related
    ENSP00000285407.6, ENST00000285407.11
    Conserved Domains (4) summary
    COG5048
    Location:374424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:374393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:429451
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:415438
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_103759.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks the 5' exon and an internal exon, and contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AP002851, BC095399, BQ575313, DA756360, HF546211
  2. NR_103760.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks the 5' exon, contains an alternate 5' exon, and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because use of translational start codon used in variant 2 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP002851, BC095399, BQ575313, DA756360, HF546210

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    102648777..102655902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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