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THRSP thyroid hormone responsive [ Homo sapiens (human) ]

Gene ID: 7069, updated on 13-Feb-2019


Official Symbol
THRSPprovided by HGNC
Official Full Name
thyroid hormone responsiveprovided by HGNC
Primary source
See related
Ensembl:ENSG00000151365 MIM:601926
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S14; Lpgp; THRP; LPGP1; SPOT14
The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]
Biased expression in fat (RPKM 186.6) and liver (RPKM 77.1) See more

Genomic context

See THRSP in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (78063861..78068357)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (77774907..77779403)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene adipogenesis associated Mth938 domain containing Neighboring gene integrator complex subunit 4 Neighboring gene NDUFC2-KCTD14 readthrough Neighboring gene potassium channel tetramerization domain containing 14 Neighboring gene uncharacterized LOC105369401 Neighboring gene NADH:ubiquinone oxidoreductase subunit C2 Neighboring gene ALG8 alpha-1,3-glucosyltransferase Neighboring gene RNA, U6 small nuclear 126, pseudogene

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?



Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

Pathways from BioSystems

  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Import of palmitoyl-CoA into the mitochondrial matrix, organism-specific biosystem (from REACTOME)
    Import of palmitoyl-CoA into the mitochondrial matrix, organism-specific biosystemThe mitochondrial carnitine system catalyzes the transport of long-chain fatty acids into the mitochondrial matrix where they undergo beta oxidation. This transport system consists of the malonyl-Co...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC21659

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
carnitine shuttle TAS
Traceable Author Statement
more info
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
regulation of triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
response to bacterium IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
cytosol TAS
Traceable Author Statement
more info
nucleoplasm IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
thyroid hormone-inducible hepatic protein
SPOT14 homolog
lipogenic protein 1
spot 14 protein
thyroid hormone responsive (SPOT14 homolog, rat)
thyroid hormone responsive SPOT14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003251.4NP_003242.1  thyroid hormone-inducible hepatic protein

    See identical proteins and their annotated locations for NP_003242.1

    Status: REVIEWED

    Source sequence(s)
    AI480357, AI749106, BC031989, BP317892
    Consensus CDS
    ENSP00000281030.2, ENST00000281030.2
    Conserved Domains (1) summary
    Spot_14; Thyroid hormone-inducible hepatic protein Spot 14

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly


  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)
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