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TGFB1I1 transforming growth factor beta 1 induced transcript 1 [ Homo sapiens (human) ]

Gene ID: 7041, updated on 15-Apr-2019

Summary

Official Symbol
TGFB1I1provided by HGNC
Official Full Name
transforming growth factor beta 1 induced transcript 1provided by HGNC
Primary source
HGNC:HGNC:11767
See related
Ensembl:ENSG00000140682 MIM:602353
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIC5; ARA55; HIC-5; TSC-5
Summary
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Expression
Broad expression in endometrium (RPKM 51.3), prostate (RPKM 29.5) and 20 other tissues See more
Orthologs

Genomic context

See TGFB1I1 in Genome Data Viewer
Location:
16p11.2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (31472155..31477960)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31483476..31489281)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 843 Neighboring gene armadillo repeat containing 5 Neighboring gene solute carrier family 5 member 2 Neighboring gene chromosome 16 open reading frame 58 Neighboring gene alpha hemoglobin stabilizing protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
I-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
Roundabout binding IPI
Inferred from Physical Interaction
more info
PubMed 
androgen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
androgen receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
morphogenesis of embryonic epithelium IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
response to heat IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
ubiquitin-dependent SMAD protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
focal adhesion HDA PubMed 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transforming growth factor beta-1-induced transcript 1 protein
Names
androgen receptor coactivator 55 kDa protein
androgen receptor coactivator ARA55
androgen receptor-associated protein of 55 kDa
hydrogen peroxide-inducible clone 5 protein
hydrogen peroxide-inducible clone-5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042454.3NP_001035919.1  transforming growth factor beta-1-induced transcript 1 protein isoform 1

    See identical proteins and their annotated locations for NP_001035919.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC026471, AK313327
    Consensus CDS
    CCDS42156.1
    UniProtKB/Swiss-Prot
    O43294
    Related
    ENSP00000378332.3, ENST00000394863.8
    Conserved Domains (5) summary
    cd09337
    Location:287338
    LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
    cd09409
    Location:346398
    LIM3_Paxillin; The third LIM domain of paxillin
    cd09412
    Location:405456
    LIM4_Leupaxin; The fourth LIM domain of Leupaxin
    cd09336
    Location:228280
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:86106
    Paxillin; Paxillin family
  2. NM_001164719.1NP_001158191.1  transforming growth factor beta-1-induced transcript 1 protein isoform 2

    See identical proteins and their annotated locations for NP_001158191.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AA992124, AC026471, BC017288
    Consensus CDS
    CCDS10713.1
    UniProtKB/Swiss-Prot
    O43294
    UniProtKB/TrEMBL
    A0A024QZE7
    Related
    ENSP00000355117.3, ENST00000361773.7
    Conserved Domains (5) summary
    cd09337
    Location:270321
    LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
    cd09409
    Location:329381
    LIM3_Paxillin; The third LIM domain of paxillin
    cd09412
    Location:388439
    LIM4_Leupaxin; The fourth LIM domain of Leupaxin
    cd09336
    Location:211263
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:6989
    Paxillin; Paxillin family
  3. NM_015927.4NP_057011.2  transforming growth factor beta-1-induced transcript 1 protein isoform 2

    See identical proteins and their annotated locations for NP_057011.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AA992124, AC026471, BC001830
    Consensus CDS
    CCDS10713.1
    UniProtKB/Swiss-Prot
    O43294
    UniProtKB/TrEMBL
    A0A024QZE7
    Related
    ENSP00000378327.2, ENST00000394858.6
    Conserved Domains (5) summary
    cd09337
    Location:270321
    LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
    cd09409
    Location:329381
    LIM3_Paxillin; The third LIM domain of paxillin
    cd09412
    Location:388439
    LIM4_Leupaxin; The fourth LIM domain of Leupaxin
    cd09336
    Location:211263
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:6989
    Paxillin; Paxillin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    31472155..31477960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450412.1XP_024306180.1  transforming growth factor beta-1-induced transcript 1 protein isoform X1

    Conserved Domains (5) summary
    cd09337
    Location:270321
    LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
    cd09409
    Location:329381
    LIM3_Paxillin; The third LIM domain of paxillin
    cd09412
    Location:388439
    LIM4_Leupaxin; The fourth LIM domain of Leupaxin
    cd09336
    Location:211263
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:6989
    Paxillin; Paxillin family
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