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TFF2 trefoil factor 2 [ Homo sapiens (human) ]

Gene ID: 7032, updated on 21-Apr-2019

Summary

Official Symbol
TFF2provided by HGNC
Official Full Name
trefoil factor 2provided by HGNC
Primary source
HGNC:HGNC:11756
See related
Ensembl:ENSG00000160181 MIM:182590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SP; SML1
Summary
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward stomach (RPKM 2591.2) See more
Orthologs

Genomic context

See TFF2 in Genome Data Viewer
Location:
21q22.3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 21 NC_000021.9 (42346357..42351099, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (43766466..43771208, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372814 Neighboring gene ATP binding cassette subfamily G member 1 Neighboring gene RNA, 5S ribosomal pseudogene 492 Neighboring gene trefoil factor 3 Neighboring gene uncharacterized LOC105372815 Neighboring gene trefoil factor 1 Neighboring gene transmembrane serine protease 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
trefoil factor 2
Names
spasmolysin
spasmolytic polypeptide
spasmolytic protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005423.5NP_005414.1  trefoil factor 2 precursor

    See identical proteins and their annotated locations for NP_005414.1

    Status: REVIEWED

    Source sequence(s)
    AA307808, BC032820, BM853946
    Consensus CDS
    CCDS13684.1
    UniProtKB/Swiss-Prot
    Q03403
    Related
    ENSP00000291526.4, ENST00000291526.5
    Conserved Domains (1) summary
    smart00018
    Location:79124
    PD; P or trefoil or TFF domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p12 Primary Assembly

    Range
    42346357..42351099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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