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TAT tyrosine aminotransferase [ Homo sapiens (human) ]

Gene ID: 6898, updated on 11-Jun-2025
Official Symbol
TATprovided by HGNC
Official Full Name
tyrosine aminotransferaseprovided by HGNC
Primary source
HGNC:HGNC:11573
See related
Ensembl:ENSG00000198650 MIM:613018; AllianceGenome:HGNC:11573
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible cognitive disability. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 242.2) See more
Orthologs
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See TAT in Genome Data Viewer
Location:
16q22.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (71565660..71577092, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (77382852..77394286, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (71599563..71610995, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903710 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:71599339-71599870 Neighboring gene RNA, U6 small nuclear 1061, pseudogene Neighboring gene TAT antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:71605697-71606896 Neighboring gene uncharacterized LOC105371334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7682 Neighboring gene MARVEL domain containing 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:71671387-71671938 Neighboring gene uncharacterized LOC124903711

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Associated conditions

Description Tests
Tyrosinemia type II
MedGen: C0268487 OMIM: 276600 GeneReviews: Tyrosinemia Type II
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EBI GWAS Catalog

Description
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
EBI GWAS Catalog
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-tyrosine-2-oxoglutarate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-tyrosine-2-oxoglutarate transaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-tyrosine-2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables L-tyrosine-2-oxoglutarate transaminase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables amino acid binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in 2-oxoglutarate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in L-phenylalanine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in L-tyrosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-tyrosine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-tyrosine catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in aromatic amino acid family catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glutamate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutamate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to dexamethasone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to mercury ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
tyrosine aminotransferase
Names
L-tyrosine:2-oxoglutarate aminotransferase
testis tissue sperm-binding protein Li 34a
tyrosine aminotransferase, cytosolic
NP_000344.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008235.1 RefSeqGene

    Range
    5004..16436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000353.3NP_000344.1  tyrosine aminotransferase

    See identical proteins and their annotated locations for NP_000344.1

    Status: REVIEWED

    Source sequence(s)
    AC010547
    Consensus CDS
    CCDS10903.1
    UniProtKB/Swiss-Prot
    B2R8I1, D3DWS2, P17735
    UniProtKB/TrEMBL
    A0A140VKB7, A1L4G7
    Related
    ENSP00000348234.4, ENST00000355962.5
    Conserved Domains (3) summary
    cd00609
    Location:74436
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    TIGR01264
    Location:41442
    tyr_amTase_E; tyrosine aminotransferase, eukaryotic
    pfam07706
    Location:140
    TAT_ubiq; Aminotransferase ubiquitination site

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    71565660..71577092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    77382852..77394286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)