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KLF5 Kruppel like factor 5 [ Homo sapiens (human) ]

Gene ID: 688, updated on 21-Apr-2019

Summary

Official Symbol
KLF5provided by HGNC
Official Full Name
Kruppel like factor 5provided by HGNC
Primary source
HGNC:HGNC:6349
See related
Ensembl:ENSG00000102554 MIM:602903
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKLF; IKLF; BTEB2
Summary
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Expression
Broad expression in skin (RPKM 92.1), esophagus (RPKM 91.6) and 14 other tissues See more
Orthologs

Genomic context

See KLF5 in Genome Data Viewer
Location:
13q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (73054976..73077542)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (73629114..73651676)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene RNA, U6 small nuclear 79, pseudogene Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 3 Neighboring gene fatty acid binding protein 5 pseudogene 1 Neighboring gene RNA, U6 small nuclear 66, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.
NHGRI GWA Catalog
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides downregulate gene expression of Kruppel-like factor 5 (KLF5) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
    Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling via exosome IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
cellular response to peptide IEA
Inferred from Electronic Annotation
more info
 
intestinal epithelial cell development IEA
Inferred from Electronic Annotation
more info
 
microvillus assembly IEA
Inferred from Electronic Annotation
more info
 
myotube differentiation involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pri-miRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by transcription factor localization IEA
Inferred from Electronic Annotation
more info
 
regulation of microvillus assembly IEA
Inferred from Electronic Annotation
more info
 
satellite cell activation involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle satellite cell differentiation IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Krueppel-like factor 5
Names
(intestinal Kruppel-like factor
BTE-binding protein 2
GC box binding protein 2
Klf5C isoform
Kruppel-like factor 5 (intestinal)
basic transcription element binding protein 2
colon krueppel-like factor
colon kruppel-like factor
epididymis secretory sperm binding protein
intestinal-enriched krueppel-like factor
intestinal-enriched kruppel-like factor
transcription factor BTEB2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286818.1NP_001273747.1  Krueppel-like factor 5 isoform 2

    See identical proteins and their annotated locations for NP_001273747.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as tKLF5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AF132818, AK131397, AK302280, BM982025
    Consensus CDS
    CCDS66562.1
    UniProtKB/Swiss-Prot
    Q13887
    Related
    ENSP00000440407.1, ENST00000539231.5
    Conserved Domains (3) summary
    COG5048
    Location:268342
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:287306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:328353
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001730.5NP_001721.2  Krueppel-like factor 5 isoform 1

    See identical proteins and their annotated locations for NP_001721.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF132818, AK131397, BC007695, BC014302, BM982025
    Consensus CDS
    CCDS9448.1
    UniProtKB/Swiss-Prot
    Q13887
    UniProtKB/TrEMBL
    Q5T6X2
    Related
    ENSP00000366915.4, ENST00000377687.6
    Conserved Domains (3) summary
    COG5048
    Location:359433
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:378397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:433455
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    73054976..73077542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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