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STATH statherin [ Homo sapiens (human) ]

Gene ID: 6779, updated on 28-Mar-2019

Summary

Official Symbol
STATHprovided by HGNC
Official Full Name
statherinprovided by HGNC
Primary source
HGNC:HGNC:11369
See related
Ensembl:ENSG00000126549 MIM:184470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STR
Expression
Restricted expression toward salivary gland (RPKM 34203.8) See more
Orthologs

Genomic context

See STATH in Genome Data Viewer
Location:
4q13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (69995931..70002456)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70861648..70868173)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene casein beta Neighboring gene uncharacterized LOC105377269 Neighboring gene histatin 3 Neighboring gene histatin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of statherin (STATH) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: HTN3

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix constituent, lubricant activity NAS
Non-traceable Author Statement
more info
PubMed 
hydroxyapatite binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of tooth enamel NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
negative regulation of bone mineralization NAS
Non-traceable Author Statement
more info
PubMed 
ossification TAS
Traceable Author Statement
more info
PubMed 
saliva secretion NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009181.1NP_001009181.1  statherin isoform b precursor

    See identical proteins and their annotated locations for NP_001009181.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    BC067219, CB958641, CB986973
    Consensus CDS
    CCDS33998.1
    UniProtKB/Swiss-Prot
    P02808
    Related
    ENSP00000370448.2, ENST00000381060.2
  2. NM_003154.2NP_003145.1  statherin isoform a precursor

    See identical proteins and their annotated locations for NP_003145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    BC067219, CB958641, CB986973
    Consensus CDS
    CCDS3533.1
    UniProtKB/Swiss-Prot
    P02808
    Related
    ENSP00000484341.1, ENST00000615994.4
    Conserved Domains (1) summary
    pfam03875
    Location:2052
    Statherin; Statherin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    69995931..70002456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_013171801.1 Reference GRCh38.p12 PATCHES

    Range
    36067..42592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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