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SRP19 signal recognition particle 19 [ Homo sapiens (human) ]

Gene ID: 6728, updated on 17-Jun-2019

Summary

Official Symbol
SRP19provided by HGNC
Official Full Name
signal recognition particle 19provided by HGNC
Primary source
HGNC:HGNC:11300
See related
Ensembl:ENSG00000153037 MIM:182175
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 11.2), bone marrow (RPKM 8.6) and 25 other tissues See more
Orthologs

Genomic context

See SRP19 in Genome Data Viewer
Location:
5q22.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (112861188..112898371)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (112196885..112228776)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene APC regulator of WNT signaling pathway Neighboring gene RNA, U6 small nuclear 482, pseudogene Neighboring gene chromobox 3 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 9882 Neighboring gene receptor accessory protein 5 Neighboring gene X-box binding protein 1 pseudogene 1 Neighboring gene ZRSR2 pseudogene 1 Neighboring gene uncharacterized LOC105379123 Neighboring gene uncharacterized LOC105379126

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag Overexpression of SRP19 reduces the HIV-1 NC-mediated packaging of 7SL RNA and A3G into virions in a dose-dependent manner PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, conserved biosystem (from KEGG)
    Protein export, conserved biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystem (from REACTOME)
    SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystemThe process for translation of a protein destined for the endoplasmic reticulum (ER) branches from the canonical cytoslic translation process at the point when a nascent polypeptide containing a hydr...
  • Translation, organism-specific biosystem (from REACTOME)
    Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
7S RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
7S RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
signal recognition particle IDA
Inferred from Direct Assay
more info
PubMed 
signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal recognition particle, endoplasmic reticulum targeting IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
signal recognition particle 19 kDa protein
Names
signal recognition particle 19kD
signal recognition particle 19kDa
NP_001191122.1
NP_001191123.1
NP_001191125.1
NP_001191128.1
NP_003126.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204193.1NP_001191122.1  signal recognition particle 19 kDa protein isoform 2

    See identical proteins and their annotated locations for NP_001191122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AA845342, AC008575, AW890522, BC017830, BY798924, CN265235
    Consensus CDS
    CCDS56375.1
    UniProtKB/Swiss-Prot
    P09132
    Related
    ENSP00000282999.3, ENST00000282999.7
    Conserved Domains (1) summary
    pfam01922
    Location:17100
    SRP19; SRP19 protein
  2. NM_001204194.1NP_001191123.1  signal recognition particle 19 kDa protein isoform 3

    See identical proteins and their annotated locations for NP_001191123.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AA845342, AC008575, AW890522, BY798924, CN265235, DN915735, X12791
    Consensus CDS
    CCDS75286.1
    UniProtKB/Swiss-Prot
    P09132
    UniProtKB/TrEMBL
    A0A087WYR0
    Related
    ENSP00000482018.1, ENST00000621420.5
    Conserved Domains (1) summary
    pfam01922
    Location:1791
    SRP19; SRP19 protein
  3. NM_001204196.1NP_001191125.1  signal recognition particle 19 kDa protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon that results in a frameshift in the central and 3' coding regions, compared to variant 1. The encoded isoform (4) has the same N-terminus but is otherwise distinct and shorter, compared to isoform 1.
    Source sequence(s)
    AA845342, AC008575, AW890522, BU661702, BY798924, CN265235
    Consensus CDS
    CCDS56376.1
    UniProtKB/Swiss-Prot
    P09132
    Related
    ENSP00000425562.1, ENST00000515463.1
  4. NM_001204199.2NP_001191128.1  signal recognition particle 19 kDa protein isoform 6

    See identical proteins and their annotated locations for NP_001191128.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 3' coding region and 3' UTR, compared to variant 1, resulting in an isoform (6) with a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC008536, AC008575, DA930867
    Consensus CDS
    CCDS87319.1
    Related
    ENSP00000375133.2, ENST00000391338.3
    Conserved Domains (1) summary
    pfam01922
    Location:17101
    SRP19; SRP19 protein
  5. NM_003135.3NP_003126.1  signal recognition particle 19 kDa protein isoform 1

    See identical proteins and their annotated locations for NP_003126.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA845342, AC008575, AW890522, CN265235, X12791
    Consensus CDS
    CCDS4108.1
    UniProtKB/Swiss-Prot
    P09132
    Related
    ENSP00000424870.1, ENST00000505459.5
    Conserved Domains (1) summary
    pfam01922
    Location:17115
    SRP19; SRP19 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    112861188..112898371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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