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SRF serum response factor [ Homo sapiens (human) ]

Gene ID: 6722, updated on 15-Apr-2019

Summary

Official Symbol
SRFprovided by HGNC
Official Full Name
serum response factorprovided by HGNC
Primary source
HGNC:HGNC:11291
See related
Ensembl:ENSG00000112658 MIM:600589
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCM1
Summary
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in prostate (RPKM 20.2), heart (RPKM 19.8) and 25 other tissues See more
Orthologs

Genomic context

See SRF in Genome Data Viewer
Location:
6p21.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (43171295..43181506)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43138920..43149244)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267958 Neighboring gene kinesin light chain 4 Neighboring gene protein tyrosine kinase 7 (inactive) Neighboring gene cullin 9 Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env The interaction of the long cytoplasmic tail of HIV-1 gp41 with the carboxy-terminal regulatory domain of p115-RhoGEF inhibits p115-mediated actin stress fiber formation and activation of serum response factor (SRF) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II sequence-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
primary miRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serum response element binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
angiogenesis involved in wound healing TAS
Traceable Author Statement
more info
PubMed 
associative learning IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
 
branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
bronchus cartilage development IEA
Inferred from Electronic Annotation
more info
 
cardiac myofibril assembly IEA
Inferred from Electronic Annotation
more info
 
cardiac vascular smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
developmental growth IEA
Inferred from Electronic Annotation
more info
 
dorsal aorta morphogenesis IEA
Inferred from Electronic Annotation
more info
 
epithelial cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
epithelial structure maintenance IEA
Inferred from Electronic Annotation
more info
 
erythrocyte development IEA
Inferred from Electronic Annotation
more info
 
eyelid development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
face development IEA
Inferred from Electronic Annotation
more info
 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
heart looping ISS
Inferred from Sequence or Structural Similarity
more info
 
heart trabecula formation IEA
Inferred from Electronic Annotation
more info
 
hematopoietic stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
long-term memory IEA
Inferred from Electronic Annotation
more info
 
long-term synaptic depression IEA
Inferred from Electronic Annotation
more info
 
lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
lung smooth muscle development IEA
Inferred from Electronic Annotation
more info
 
mRNA transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
megakaryocyte development IEA
Inferred from Electronic Annotation
more info
 
mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
morphogenesis of an epithelial sheet IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle cell cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of amyloid-beta clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of pri-miRNA transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron development TAS
Traceable Author Statement
more info
PubMed 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
neuron projection development IEA
Inferred from Electronic Annotation
more info
 
platelet activation IEA
Inferred from Electronic Annotation
more info
 
platelet formation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of filopodium assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pri-miRNA transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of smooth muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by glucose IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription initiation from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription via serum response element binding IDA
Inferred from Direct Assay
more info
PubMed 
positive thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 
primitive streak formation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of smooth muscle cell differentiation TAS
Traceable Author Statement
more info
PubMed 
regulation of water loss via skin IEA
Inferred from Electronic Annotation
more info
 
response to cytokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cytokine NAS
Non-traceable Author Statement
more info
PubMed 
response to hormone IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to toxic substance TAS
Traceable Author Statement
more info
PubMed 
sarcomere organization IEA
Inferred from Electronic Annotation
more info
 
skin morphogenesis IEA
Inferred from Electronic Annotation
more info
 
stress fiber assembly IEA
Inferred from Electronic Annotation
more info
 
tangential migration from the subventricular zone to the olfactory bulb IEA
Inferred from Electronic Annotation
more info
 
thymus development IEA
Inferred from Electronic Annotation
more info
 
thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
trachea cartilage development IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
trophectodermal cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
nuclear chromatin IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serum response factor
Names
c-fos serum response element-binding transcription factor
minichromosome maintenance 1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001292001.1NP_001278930.1  serum response factor isoform 2

    See identical proteins and their annotated locations for NP_001278930.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK300467, BC052572
    UniProtKB/Swiss-Prot
    P11831
    UniProtKB/TrEMBL
    B4DU24
  2. NM_003131.4NP_003122.1  serum response factor isoform 1

    See identical proteins and their annotated locations for NP_003122.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL355385, BC052572
    Consensus CDS
    CCDS4889.1
    UniProtKB/Swiss-Prot
    P11831
    UniProtKB/TrEMBL
    A0A024RD16
    Related
    ENSP00000265354.4, ENST00000265354.6
    Conserved Domains (1) summary
    cd00266
    Location:142223
    MADS_SRF_like; SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    43171295..43181506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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