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SPRR2A small proline rich protein 2A [ Homo sapiens (human) ]

Gene ID: 6700, updated on 27-Nov-2024

Summary

Official Symbol
SPRR2Aprovided by HGNC
Official Full Name
small proline rich protein 2Aprovided by HGNC
Primary source
HGNC:HGNC:11261
See related
Ensembl:ENSG00000241794 MIM:182267; AllianceGenome:HGNC:11261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables lipid binding activity. Involved in antibacterial humoral response and defense response to Gram-positive bacterium. Located in cytoplasm. Is active in extracellular region and secretory granule. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward esophagus (RPKM 1789.3) See more
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Genomic context

See SPRR2A in Genome Data Viewer
Location:
1q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153056120..153057512, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152192883..152194275, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153028596..153029988, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small proline rich protein 1B Neighboring gene small proline rich protein 2D Neighboring gene small proline rich protein 2B Neighboring gene small proline rich protein 2E

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cornified envelope TAS
Traceable Author Statement
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
small proline-rich protein 2A
Names
2-1
SPR-2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005988.3NP_005979.1  small proline-rich protein 2A

    See identical proteins and their annotated locations for NP_005979.1

    Status: VALIDATED

    Source sequence(s)
    BE710686, CA433267, X53064
    Consensus CDS
    CCDS1034.1
    UniProtKB/Swiss-Prot
    B2R4T3, D3DV35, P35326, Q5T529
    Related
    ENSP00000376423.2, ENST00000392653.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    153056120..153057512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    152192883..152194275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)