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SNCG synuclein gamma [ Homo sapiens (human) ]

Gene ID: 6623, updated on 13-Feb-2019

Summary

Official Symbol
SNCGprovided by HGNC
Official Full Name
synuclein gammaprovided by HGNC
Primary source
HGNC:HGNC:11141
See related
Ensembl:ENSG00000173267 MIM:602998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SR; BCSG1
Summary
This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010]
Expression
Biased expression in fat (RPKM 120.9), urinary bladder (RPKM 74.6) and 8 other tissues See more
Orthologs

Genomic context

See SNCG in Genome Data Viewer
Location:
10q23.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (86955801..86963260)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (88717504..88723017)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein receptor type 1A Neighboring gene RNA polymerase II associated protein 2 pseudogene 1 Neighboring gene RNA, U1 small nuclear 19, pseudogene Neighboring gene multimerin 2 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 11 Neighboring gene adipogenesis regulatory factor Neighboring gene BMS1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
protein secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of dopamine secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
synapse organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
gamma-synuclein
Names
-synuclein
E pound-synuclein
breast cancer-specific gene 1 protein
persyn
synoretin
synuclein, gamma (breast cancer-specific protein 1)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008783.1 RefSeqGene

    Range
    5001..9730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330120.1NP_001317049.1  gamma-synuclein isoform 2

    Status: REVIEWED

    Source sequence(s)
    BC014098, BG708703, EB388950
    Consensus CDS
    CCDS81483.1
    UniProtKB/Swiss-Prot
    O76070
    UniProtKB/TrEMBL
    F8W754
    Related
    ENSP00000344658.4, ENST00000348795.8
    Conserved Domains (1) summary
    pfam01387
    Location:154
    Synuclein; Synuclein
  2. NM_003087.3NP_003078.2  gamma-synuclein isoform 1

    See identical proteins and their annotated locations for NP_003078.2

    Status: REVIEWED

    Source sequence(s)
    AK223367, BC014098
    Consensus CDS
    CCDS7380.1
    UniProtKB/Swiss-Prot
    O76070
    UniProtKB/TrEMBL
    Q6FHG5
    Related
    ENSP00000361087.3, ENST00000372017.3
    Conserved Domains (1) summary
    pfam01387
    Location:1110
    Synuclein; Synuclein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    86955801..86963260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448137.1XP_024303905.1  gamma-synuclein isoform X1

    Conserved Domains (1) summary
    pfam01387
    Location:154
    Synuclein
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