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ERVK-6 endogenous retrovirus group K member 6, envelope [ Homo sapiens (human) ]

Gene ID: 64006, updated on 4-Jan-2025

Summary

Official Symbol
ERVK-6provided by HGNC
Official Full Name
endogenous retrovirus group K member 6, envelopeprovided by HGNC
Primary source
HGNC:HGNC:13915
See related
MIM:605626; AllianceGenome:HGNC:13915
Gene type
other
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
cORF; ERVK6; K-Rev; c-orf; envK2; HERV-K108; HERV-K(C7)
Summary
Enables RNA stem-loop binding activity and protein homodimerization activity. Involved in mRNA export from nucleus; positive regulation of gene expression; and protein homooligomerization. Located in cytoplasm and nucleolus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jan 2025]
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Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • Endogenous retrovirus group K member 6 Env polyprotein
  • Envelope polyprotein
  • HERV-K (HML-2.HOM)
  • HERV-K(C7) envelope protein
  • HERV-K(HML-2.HOM) envelope protein
  • HERV-K108 envelope protein
  • HERV-K_7p22.1 provirus Rec protein
  • HERV-K_7p22.1 provirus ancestral Env polyprotein
  • HERV-K_7p22.1 provirus ancestral Pol protein
  • HERV-K_7p22.1 provirus ancestral Pro protein
  • Rev-like protein
  • Rev/Rex homolog
  • endogenous retroviral sequence K, 6
  • endogenous retrovirus group K, member 6
  • envelope glycoprotein
  • envelope protein

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA stem-loop binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA stem-loop binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA-DNA hybrid ribonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
enables telomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA integration IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA synthesis involved in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in RNA-templated DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein homooligomerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in syncytium formation by plasma membrane fusion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in viral translational frameshifting IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007236.1: Suppressed sequence

    Description
    NM_001007236.1: This RefSeq was permanently discontinued as it represents an expressed retrovirus and is considered out of scope.