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CLEC11A C-type lectin domain containing 11A [ Homo sapiens (human) ]

Gene ID: 6320, updated on 13-Feb-2019

Summary

Official Symbol
CLEC11Aprovided by HGNC
Official Full Name
C-type lectin domain containing 11Aprovided by HGNC
Primary source
HGNC:HGNC:10576
See related
Ensembl:ENSG00000105472 MIM:604713
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P47; SCGF; LSLCL; CLECSF3
Summary
This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 36.6), endometrium (RPKM 6.5) and 15 other tissues See more
Orthologs

Genomic context

See CLEC11A in Genome Data Viewer
Location:
19q13.33
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (50723348..50725724)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51226588..51228981)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene synaptotagmin 3 Neighboring gene chromosome 19 open reading frame 81 Neighboring gene SH3 and multiple ankyrin repeat domains 1 Neighboring gene GPR32 pseudogene 1 Neighboring gene G protein-coupled receptor 32

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding NAS
Non-traceable Author Statement
more info
PubMed 
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ossification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
C-type lectin domain family 11 member A
Names
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 3
C-type lectin superfamily member 3
lymphocyte secreted C-type lectin
lymphocyte secreted long form of C-type lectin
osteolectin
stem cell growth factor
stem cell growth factor; lymphocyte secreted C-type lectin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002975.3NP_002966.1  C-type lectin domain family 11 member A precursor

    See identical proteins and their annotated locations for NP_002966.1

    Status: REVIEWED

    Source sequence(s)
    AF020044, BQ014793
    Consensus CDS
    CCDS12800.1
    UniProtKB/Swiss-Prot
    Q9Y240
    Related
    ENSP00000250340.3, ENST00000250340.8
    Conserved Domains (1) summary
    cd03596
    Location:177321
    CLECT_tetranectin_like; C-type lectin-like domain (CTLD) of the type found in the tetranectin (TN), cartilage derived C-type lectin (CLECSF1), and stem cell growth factor (SCGF)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    50723348..50725724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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