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RPL22 ribosomal protein L22 [ Homo sapiens (human) ]

Gene ID: 6146, updated on 5-May-2024

Summary

Official Symbol
RPL22provided by HGNC
Official Full Name
ribosomal protein L22provided by HGNC
Primary source
HGNC:HGNC:10315
See related
Ensembl:ENSG00000116251 MIM:180474; AllianceGenome:HGNC:10315
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EAP; L22; eL22; HBP15; HBP15/L22
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 336.6), endometrium (RPKM 190.1) and 25 other tissues See more
Orthologs
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Genomic context

See RPL22 in Genome Data Viewer
Location:
1p36.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (6185020..6199595, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (5710666..5725241, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6245080..6259655, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 2 Neighboring gene uncharacterized LOC124903831 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6162189-6162690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6162691-6163190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 137 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6186229-6187116 Neighboring gene Sharpr-MPRA regulatory region 11871 Neighboring gene chromodomain helicase DNA binding protein 5 Neighboring gene MPRA-validated peak27 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6225727-6226227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6238637-6239138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6239139-6239638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 138 Neighboring gene Sharpr-MPRA regulatory region 5942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6265555-6266374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 140 Neighboring gene Sharpr-MPRA regulatory region 13921 Neighboring gene RNF207 antisense RNA 1 Neighboring gene MPRA-validated peak28 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6279526-6279711 Neighboring gene ring finger protein 207 Neighboring gene isoprenylcysteine carboxyl methyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in alpha-beta T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytoplasmic translation IC
Inferred by Curator
more info
PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translation at presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
large ribosomal subunit protein eL22
Names
60S ribosomal protein L22
EBER-associated protein
Epstein-Barr virus small RNA-associated protein
Epstein-Barr-encoded RNA-associated protein
heparin-binding protein 15
heparin-binding protein HBp15
NP_000974.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000983.4NP_000974.1  large ribosomal subunit protein eL22

    See identical proteins and their annotated locations for NP_000974.1

    Status: REVIEWED

    Source sequence(s)
    AF113701, AK097075, CA336134
    Consensus CDS
    CCDS58.1
    UniProtKB/Swiss-Prot
    B2R495, P35268, Q6IBD1
    UniProtKB/TrEMBL
    Q7Z4W8
    Related
    ENSP00000346088.3, ENST00000234875.9
    Conserved Domains (1) summary
    pfam01776
    Location:21119
    Ribosomal_L22e; Ribosomal L22e protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    6185020..6199595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    5710666..5725241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)