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RBL2 RB transcriptional corepressor like 2 [ Homo sapiens (human) ]

Gene ID: 5934, updated on 15-Apr-2019

Summary

Official Symbol
RBL2provided by HGNC
Official Full Name
RB transcriptional corepressor like 2provided by HGNC
Primary source
HGNC:HGNC:9894
See related
Ensembl:ENSG00000103479 MIM:180203
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Rb2; P130
Expression
Ubiquitous expression in lymph node (RPKM 41.9), testis (RPKM 38.9) and 25 other tissues See more
Orthologs

Genomic context

See RBL2 in Genome Data Viewer
Location:
16q12.2
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (53434420..53491648)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (53468351..53525560)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene u3 small nucleolar ribonucleoprotein protein MPP10-like Neighboring gene uncharacterized LOC102723373 Neighboring gene RNA, U6 small nuclear 1153, pseudogene Neighboring gene AKT interacting protein Neighboring gene uncharacterized LOC105371268 Neighboring gene uncharacterized LOC105371269

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed
Tat tat HIV-1 Tat can inhibit the growth control activity exerted by pRb2/p130 in the T98G cell line, and results show that pRb2/p130 mRNA levels increase in the presence of Tat, whereas no change in the phosphorylation status of pRb2/p130 is observed PubMed
tat HIV-1 Tat protein specifically binds to pRb2/p130 and data suggest this interaction results in the deregulation of the control exerted by pRb2/p130 on the cell cycle, indicating a potential role in AIDS-related oncogenesis PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
    Cyclin D associated events in G1, organism-specific biosystemThree D-type cyclins are essential for progression from G1 to S-phase. These D cyclins bind to and activate both CDK4 and CDK6. The formation of all possible complexes between the D-type cyclins and...
  • DNA Damage Response (only ATM dependent), organism-specific biosystem (from WikiPathways)
    DNA Damage Response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
  • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    E2F transcription factor network, organism-specific biosystem
    E2F transcription factor network
  • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
    FoxO family signaling, organism-specific biosystem
    FoxO family signaling
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • G0 and Early G1, organism-specific biosystem (from REACTOME)
    G0 and Early G1, organism-specific biosystemIn G0 and early G1 in quiescent cells, p130 (RBL2) bound to E2F4 or E2F5 and either DP1 or DP2, associates with the MuvB complex, forming an evolutionarily conserved DREAM complex, that represses tra...
  • G1 Phase, organism-specific biosystem (from REACTOME)
    G1 Phase, organism-specific biosystemEarly cell cycle progression in G1 is under the control of the D-type cyclins together with Cdk4 and Cdk6. An important target for these CDKs is the Retinoblastoma (Rb) protein, which when phosphoryl...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Human Thyroid Stimulating Hormone (TSH) signaling pathway, organism-specific biosystem (from WikiPathways)
    Human Thyroid Stimulating Hormone (TSH) signaling pathway, organism-specific biosystemHuman thyroid stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in regulation of the hypothalamus-pituitary-th...
  • ID signaling pathway, organism-specific biosystem (from WikiPathways)
    ID signaling pathway, organism-specific biosystemThe Inhibitor of DNA binding (ID) proteins belong to the class V HLH family of transcription factors. Four ID proteins (ID 1-4)are known in humans. Unlike the basic HLH (bHLH) transcription factors, ...
  • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
    Mitotic G1-G1/S phases, organism-specific biosystem
    Mitotic G1-G1/S phases
  • Monoamine Transport, organism-specific biosystem (from WikiPathways)
    Monoamine Transport, organism-specific biosystem
    Monoamine Transport
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
  • TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystem (from REACTOME)
    TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystemUnder a variety of stress conditions, TP53 (p53), stabilized by stress-induced phosphorylation at least on S15 and S20 serine residues, can induce the transcription of genes involved in cell cycle ar...
  • TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, organism-specific biosystem (from REACTOME)
    TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, organism-specific biosystemTP53 contributes to the establishment of G2 arrest by inducing transcription of GADD45A and SFN, and by inhibiting transcription of CDC25C. TP53 induces GADD45A transcription in cooperation with chro...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26459

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II activating transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
colocalizes_with nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
retinoblastoma-like protein 2
Names
130 kDa retinoblastoma-associated protein
PRB2
RBR-2
retinoblastoma-like 2
retinoblastoma-related protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323608.1NP_001310537.1  retinoblastoma-like protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007342
    Consensus CDS
    CCDS10748.1
    UniProtKB/Swiss-Prot
    Q08999
    Conserved Domains (3) summary
    pfam01857
    Location:8351017
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:417609
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:104236
    DUF3452; Domain of unknown function (DUF3452)
  2. NM_001323609.1NP_001310538.1  retinoblastoma-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC007342
  3. NM_001323610.1NP_001310539.1  retinoblastoma-like protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC007342
  4. NM_001323611.1NP_001310540.1  retinoblastoma-like protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC007342
    Conserved Domains (3) summary
    pfam01857
    Location:761943
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:343535
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:30162
    DUF3452; Domain of unknown function (DUF3452)
  5. NM_005611.4NP_005602.3  retinoblastoma-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_005602.3

    Status: VALIDATED

    Source sequence(s)
    BC034490, X76061
    Consensus CDS
    CCDS10748.1
    UniProtKB/Swiss-Prot
    Q08999
    Related
    ENSP00000262133.6, ENST00000262133.11
    Conserved Domains (3) summary
    pfam01857
    Location:8351017
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:417609
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:104236
    DUF3452; Domain of unknown function (DUF3452)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    53434420..53491648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523253.2XP_011521555.1  retinoblastoma-like protein 2 isoform X1

    Conserved Domains (3) summary
    pfam01857
    Location:619801
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:201393
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:120
    DUF3452; Domain of unknown function (DUF3452)
  2. XM_017023513.1XP_016879002.1  retinoblastoma-like protein 2 isoform X1

    Conserved Domains (3) summary
    pfam01857
    Location:619801
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:201393
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:120
    DUF3452; Domain of unknown function (DUF3452)
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