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RBBP7 RB binding protein 7, chromatin remodeling factor [ Homo sapiens (human) ]

Gene ID: 5931, updated on 7-Apr-2019

Summary

Official Symbol
RBBP7provided by HGNC
Official Full Name
RB binding protein 7, chromatin remodeling factorprovided by HGNC
Primary source
HGNC:HGNC:9890
See related
Ensembl:ENSG00000102054 MIM:300825
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RbAp46
Summary
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in adrenal (RPKM 151.2), testis (RPKM 63.0) and 24 other tissues See more
Orthologs

Genomic context

See RBBP7 in Genome Data Viewer
Location:
Xp22.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (16844650..16870411, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (16862773..16888565, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, U7 small nuclear 56 pseudogene Neighboring gene taxilin gamma Neighboring gene RNA, U4 small nuclear 6, pseudogene Neighboring gene solute carrier family 35 member C2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The SIN3/HDAC complex, composed of SIN3A, SAP30, SAP18, HDAC-1 AND -2 and RbAp46/48 except SAP30, is identified to interact with HIV-1 Tat in Jurkat cell PubMed
Vpr vpr HIV-1 Vpr forms a complex by recruiting RbAp46, HAT1, ZIP/sZIP, and Cul4A PubMed
vpr HIV-1 Vpr is identified to have a physical interaction with retinoblastoma binding protein 7 (RBBP7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138867, MGC138868

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
DNA replication IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular heat acclimation IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of G0 to G1 transition TAS
Traceable Author Statement
more info
 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression, epigenetic TAS
Traceable Author Statement
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
response to steroid hormone IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone-binding protein RBBP7
Names
G1/S transition control protein-binding protein RbAp46
RBBP-7
histone acetyltransferase type B subunit 2
nucleosome-remodeling factor subunit RBAP46
retinoblastoma-binding protein 7
retinoblastoma-binding protein RbAp46
retinoblastoma-binding protein p46

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198719.1NP_001185648.1  histone-binding protein RBBP7 isoform 1

    See identical proteins and their annotated locations for NP_001185648.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK091911, BQ775345, DA924163
    Consensus CDS
    CCDS56598.1
    UniProtKB/Swiss-Prot
    Q16576
    Related
    ENSP00000369424.4, ENST00000380084.8
    Conserved Domains (4) summary
    COG2319
    Location:157451
    WD40; WD40 repeat [General function prediction only]
    pfam12265
    Location:62130
    CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
    sd00039
    Location:171218
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:166446
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_002893.3NP_002884.1  histone-binding protein RBBP7 isoform 2

    See identical proteins and their annotated locations for NP_002884.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL929302, BC114501, CN414343, DB460068
    Consensus CDS
    CCDS14179.1
    UniProtKB/Swiss-Prot
    Q16576
    UniProtKB/TrEMBL
    Q6FHQ0
    Related
    ENSP00000369427.2, ENST00000380087.6
    Conserved Domains (3) summary
    sd00039
    Location:127174
    7WD40; WD40 repeat [structural motif]
    pfam12265
    Location:1887
    CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
    cl25539
    Location:122402
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    16844650..16870411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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