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PTGER3 prostaglandin E receptor 3 [ Homo sapiens (human) ]

Gene ID: 5733, updated on 21-Apr-2019

Summary

Official Symbol
PTGER3provided by HGNC
Official Full Name
prostaglandin E receptor 3provided by HGNC
Primary source
HGNC:HGNC:9595
See related
Ensembl:ENSG00000050628 MIM:176806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EP3; EP3e; EP3-I; EP3-II; EP3-IV; EP3-VI; PGE2-R; EP3-III
Summary
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Expression
Biased expression in endometrium (RPKM 21.7), kidney (RPKM 19.2) and 8 other tissues See more
Orthologs

Genomic context

See PTGER3 in Genome Data Viewer
Location:
1p31.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (70852353..71047808, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (71318036..71513497, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene caspase 3 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1788 Neighboring gene uncharacterized LOC102724572 Neighboring gene uncharacterized LOC107985517 Neighboring gene ZRANB2 antisense RNA 1 Neighboring gene uncharacterized LOC105378795 Neighboring gene ZRANB2 antisense RNA 2 (head to head) Neighboring gene zinc finger RANBP2-type containing 2 Neighboring gene microRNA 186

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

Pathways from BioSystems

  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • Eicosanoid ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Eicosanoid ligand-binding receptors, organism-specific biosystemEicosanoids, derived from polyunsaturated 20-carbon fatty acids, are paracrine and autocrine regulators of inflammation, smooth muscle contraction, and blood coagulation. The actions of eicosanoids a...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Prostaglandin Synthesis and Regulation, organism-specific biosystem (from WikiPathways)
    Prostaglandin Synthesis and Regulation, organism-specific biosystemA prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon ato...
  • Prostanoid ligand receptors, organism-specific biosystem (from REACTOME)
    Prostanoid ligand receptors, organism-specific biosystemFatty acid cyclo-oxygenase (COX) converts arachidonic acid to prostaglandin H2 (PGH2) from which the prostanoids PGD2, PGE2, PGF2alpha, PGI2 (prostacyclin) and thromboxane A2 (TXA2) are derived. Base...
  • Regulation of lipolysis in adipocytes, organism-specific biosystem (from KEGG)
    Regulation of lipolysis in adipocytes, organism-specific biosystemLipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Small Ligand GPCRs, organism-specific biosystem (from WikiPathways)
    Small Ligand GPCRs, organism-specific biosystem
    Small Ligand GPCRs
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27302, MGC141828, MGC141829

Gene Ontology Provided by GOA

Function Evidence Code Pubs
prostaglandin E receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cell death TAS
Traceable Author Statement
more info
PubMed 
positive regulation of fever generation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prostaglandin E2 receptor EP3 subtype
Names
PGE receptor, EP3 subtype
PGE2 receptor EP3 subtype
prostaglandin E receotor EP3 subtype 3 isoform
prostaglandin E receptor 3 (subtype EP3)
prostaglandin receptor (PGE-2)
prostanoid EP3 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029509.2 RefSeqGene

    Range
    5001..200456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001126044.1NP_001119516.1  prostaglandin E2 receptor EP3 subtype isoform 4

    See identical proteins and their annotated locations for NP_001119516.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) has multiple differences compared to variant 1. The resulting protein (isoform 4) has a distinct and shorter C-terminus, as compared to isoform 1. Transcript variants 4, 9 and 11 encode the same protein. Another name for this transcript is EP3 subtype 1c.
    Source sequence(s)
    AL031429, S69326
    Consensus CDS
    CCDS656.1
    UniProtKB/Swiss-Prot
    P43115
    Conserved Domains (1) summary
    pfam00001
    Location:65346
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_198714.1NP_942007.1  prostaglandin E2 receptor EP3 subtype isoform 4

    See identical proteins and their annotated locations for NP_942007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences compared to variant 1. The resulting protein (isoform 4) has a distinct and shorter C-terminus, as compared to isoform 1. Transcript variants 4, 9 and 11 encode the same protein. Other names for variant 4 are EP3 subtype 1b, pEPR-Ib, and EP3a1.
    Source sequence(s)
    AL158087, D38298, X83861, X83863
    Consensus CDS
    CCDS656.1
    UniProtKB/Swiss-Prot
    P43115
    Related
    ENSP00000359969.3, ENST00000370931.7
    Conserved Domains (1) summary
    pfam00001
    Location:65346
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_198715.2NP_942008.1  prostaglandin E2 receptor EP3 subtype isoform 5

    See identical proteins and their annotated locations for NP_942008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks multiple 3' exons and has an unique 3' end region when compared to variant 1. The resulting protein (isoform 5) has a distinct and shorter C-terminus, as compared to isoform 1. Other names for this transcript are EP3-II, EP3C, and EP3D.
    Source sequence(s)
    AL031429, D38299
    Consensus CDS
    CCDS658.1
    UniProtKB/Swiss-Prot
    P43115
    Related
    ENSP00000359962.3, ENST00000370924.4
    Conserved Domains (1) summary
    cd15146
    Location:49358
    7tmA_PGE2_EP3; prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_198716.1NP_942009.1  prostaglandin E2 receptor EP3 subtype isoform 6

    See identical proteins and their annotated locations for NP_942009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two coding exons compared to variant 1. The resulting protein (isoform 6) has a distinct and shorter C-terminus, as compared to isoform 1. Other names for this transcript are EP3F and EP3d.
    Source sequence(s)
    AL158087, BC024229, X83861, X83863
    Consensus CDS
    CCDS652.1
    UniProtKB/Swiss-Prot
    P43115
    Related
    ENSP00000418073.1, ENST00000460330.5
    Conserved Domains (1) summary
    cd15146
    Location:49358
    7tmA_PGE2_EP3; prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_198717.1NP_942010.1  prostaglandin E2 receptor EP3 subtype isoform 7

    See identical proteins and their annotated locations for NP_942010.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks multiple exons compared to variant 1. The resulting protein (isoform 7) has a distinct and shorter C-terminus as compared to isoform 1. Other names for this transcript are EP3b and EP3E.
    Source sequence(s)
    AL158087, D38301, X83861, X83863
    Consensus CDS
    CCDS44160.1
    UniProtKB/Swiss-Prot
    P43115
    Related
    ENSP00000486617.1, ENST00000628037.2
    Conserved Domains (1) summary
    cd15146
    Location:49358
    7tmA_PGE2_EP3; prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. NM_198718.1NP_942011.1  prostaglandin E2 receptor EP3 subtype isoform 8

    See identical proteins and their annotated locations for NP_942011.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has multiple differences compared to variant 1. The resulting protein (isoform 8) has a distinct and shorter C-terminus, as compared to isoform 1. Another name for this transcript is EP3e.
    Source sequence(s)
    AL031429, D86097, X83862
    Consensus CDS
    CCDS655.1
    UniProtKB/Swiss-Prot
    P43115
    UniProtKB/TrEMBL
    O00325
    Related
    ENSP00000349003.4, ENST00000356595.8
    Conserved Domains (1) summary
    pfam00001
    Location:65346
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  7. NM_198719.1NP_942012.1  prostaglandin E2 receptor EP3 subtype isoform 4

    See identical proteins and their annotated locations for NP_942012.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple differences compared to variant 1. The resulting protein (isoform 4) has a distinct and shorter C-terminus, as compared to isoform 1. Transcript variants 4, 9 and 11 encode the same protein. Other names for variant 9 are EP3A, EP3-I, EP3a2, and EP3 subtype 1a.
    Source sequence(s)
    AI273491, D38297
    Consensus CDS
    CCDS657.1
    UniProtKB/Swiss-Prot
    P43115
    Related
    ENSP00000302313.5, ENST00000306666.9
    Conserved Domains (1) summary
    pfam00001
    Location:65346
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RNA

  1. NR_028292.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as EP3-V, lacks one exon and includes an additional exon near the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 7, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL158087, D86097
    Related
    ENST00000361210.6
  2. NR_028293.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as EP3-VI, lacks two and includes one alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 7, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL158087, D86098
    Related
    ENST00000479353.5
  3. NR_028294.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as EP3f, represents the longest transcript. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 7, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL158087, D86097, X83863
    Related
    ENST00000497146.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    70852353..71047808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541810.3XP_011540112.1  prostaglandin E2 receptor EP3 subtype isoform X1

    Related
    ENSP00000280208.8, ENST00000351052.9
    Conserved Domains (1) summary
    pfam00001
    Location:65346
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RNA

  1. XR_946714.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_000957.2: Suppressed sequence

    Description
    NM_000957.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_198712.2: Suppressed sequence

    Description
    NM_198712.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  3. NM_198713.1: Suppressed sequence

    Description
    NM_198713.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  4. NM_198720.1: Suppressed sequence

    Description
    NM_198720.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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