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PYY peptide YY [ Homo sapiens (human) ]

Gene ID: 5697, updated on 9-Jun-2025
Official Symbol
PYYprovided by HGNC
Official Full Name
peptide YYprovided by HGNC
Primary source
HGNC:HGNC:9748
See related
Ensembl:ENSG00000131096 MIM:600781; AllianceGenome:HGNC:9748
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PYY1; PYY-I
Summary
This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]
Expression
Biased expression in colon (RPKM 24.9) and small intestine (RPKM 4.4) See more
Orthologs
mouse all
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See PYY in Genome Data Viewer
Location:
17q21.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43952733..44004445, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (44805282..44856956, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (42030101..42081813, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:42015415-42015915 Neighboring gene long intergenic non-protein coding RNA 1976 Neighboring gene pancreatic polypeptide Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:42030343-42030846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:42082913-42083668 Neighboring gene Sharpr-MPRA regulatory region 11566 Neighboring gene N-acetylglutamate synthase Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:42091474-42092673 Neighboring gene Sharpr-MPRA regulatory region 15580 Neighboring gene transmembrane protein 101

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Peptide YY in adolescent athletes with amenorrhea, eumenorrheic athletes and non-athletic controls. Russell M, et al. Bone, 2009 Jul. PMID 19344792, Free PMC Article
  2. The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR. Nygaard R, et al. Biochemistry, 2006 Jul 11. PMID 16819834
  3. Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women. Weickert MO, et al. J Negat Results Biomed, 2006 Aug 14. PMID 16907966, Free PMC Article
  4. Gastric sensorimotor functions and hormone profile in normal weight, overweight, and obese people. Vazquez Roque MI, et al. Gastroenterology, 2006 Dec. PMID 17087952
  5. Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36. Pfluger PT, et al. J Clin Endocrinol Metab, 2007 Feb. PMID 17119001

See all (136) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells.
    Title: RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells.
  2. Peptide YY inhibits transcription and replication of hepatitis B virus by suppressing promoter/enhancer activity.
    Title: Peptide YY inhibits transcription and replication of hepatitis B virus by suppressing promoter/enhancer activity.
  3. Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.
    Title: Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.
  4. Emerging evidence of the relationship between fat-free mass and ghrelin, glucagon-like peptide-1, and peptide-YY.
    Title: Emerging evidence of the relationship between fat-free mass and ghrelin, glucagon-like peptide-1, and peptide-YY.
  5. Crystal structures of human neuropeptide Y (NPY) and peptide YY (PYY).
    Title: Crystal structures of human neuropeptide Y (NPY) and peptide YY (PYY).
  6. Single nucleotide polymorphism in CD36: Correlation to peptide YY levels in obese and non-obese adults.
    Title: Single nucleotide polymorphism in CD36: Correlation to peptide YY levels in obese and non-obese adults.
  7. Real-time RT-PCR revealed that Intermittent Hypoxia significantly increased the mRNA levels of peptide YY (PYY), glucagon-like peptide-1 (GLP-1), and neurotensin (NTS) in Caco-2 cells.
    Title: Intermittent Hypoxia Up-Regulates Gene Expressions of Peptide YY (PYY), Glucagon-like Peptide-1 (GLP-1), and Neurotensin (NTS) in Enteroendocrine Cells.
  8. the current review aims to compile, evaluate and summarise current knowledge on PYY, with particular emphasis on obesity and diabetes treatment, and the importance of specific Y receptor interactions for this.
    Title: Emerging therapeutic potential for peptide YY for obesity-diabetes.
  9. Data show that peptide YY (PYY) mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets.
    Title: Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets.
  10. Data suggest that dose/intensity-response relationships exist between exercise intensity and total plasma PYY levels, though the effects on total plasma GLP1 levels and hunger perceptions seem unclear. (PYY = peptide YY ; GLP1 = glucagon-like peptide 1)
    Title: Total PYY and GLP-1 responses to submaximal continuous and supramaximal sprint interval cycling in men.
Submit: New GeneRIF Correction See all GeneRIFs (103)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables hormone activity TAS
Traceable Author Statement
more info
 PubMed 
enables neuropeptide Y receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in feeding behavior IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in feeding behavior TAS
Traceable Author Statement
more info
 PubMed 
involved_in intestinal epithelial cell differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
peptide YY
Names
peptide tyrosine tyrosine
prepro-PYY

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023338.2 RefSeqGene

    Range
    55505..56712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001394028.1 → NP_001380957.1  peptide YY isoform 1 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC007993
    Consensus CDS
    CCDS32662.1
    UniProtKB/Swiss-Prot
    P10082, Q5U5Q6, Q6FGH8
    Related
    ENSP00000509262.1, ENST00000692052.1
    Conserved Domains (1) summary
    smart00309
    Location:29 → 64
    PAH; Pancreatic hormones / neuropeptide F / peptide YY family

  2. NM_001394029.1 → NP_001380958.1  peptide YY isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007993
    Consensus CDS
    CCDS92333.1
    Related
    ENSP00000467310.1, ENST00000592796.2
    Conserved Domains (1) summary
    smart00309
    Location:29 → 64
    PAH; Pancreatic hormones / neuropeptide F / peptide YY family

  3. NM_004160.6 → NP_004151.4  peptide YY isoform 1 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC007993, AC023855
    Consensus CDS
    CCDS32662.1
    UniProtKB/Swiss-Prot
    P10082, Q5U5Q6, Q6FGH8
    Related
    ENSP00000353198.1, ENST00000360085.6
    Conserved Domains (1) summary
    smart00309
    Location:29 → 64
    PAH; Pancreatic hormones / neuropeptide F / peptide YY family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    43952733..44004445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    44805282..44856956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10082.3 GenPept UniProtKB/Swiss-Prot:P10082

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