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RNF20 ring finger protein 20 [ Homo sapiens (human) ]

Gene ID: 56254, updated on 15-Apr-2019

Summary

Official Symbol
RNF20provided by HGNC
Official Full Name
ring finger protein 20provided by HGNC
Primary source
HGNC:HGNC:10062
See related
Ensembl:ENSG00000155827 MIM:607699
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRE1; BRE1A; hBRE1
Summary
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in testis (RPKM 16.7), brain (RPKM 13.7) and 25 other tissues See more
Orthologs

Genomic context

See RNF20 in Genome Data Viewer
Location:
9q31.1
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (101533849..101563344)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (104296131..104325626)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NFE2L2 motif-containing MPRA enhancer 257 Neighboring gene TMEM246 antisense RNA 1 Neighboring gene transmembrane protein 246 Neighboring gene glutamate ionotropic receptor NMDA type subunit 3A Neighboring gene uncharacterized LOC105376186 Neighboring gene protein phosphatase 3 regulatory subunit B, beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify E3 ubiquitin protein ligase ring finger protein 20 (RNF20; BRE1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify E3 ubiquitin protein ligase ring finger protein 20 (RNF20; BRE1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify E3 ubiquitin protein ligase ring finger protein 20 (RNF20; BRE1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify E3 ubiquitin protein ligase ring finger protein 20 (RNF20; BRE1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • ATM Signaling Network in Development and Disease, organism-specific biosystem (from WikiPathways)
    ATM Signaling Network in Development and Disease, organism-specific biosystemThis pathway is modeled after Figure 4 in the article "The ATM signaling network in development and disease" (See Bibliography). When DNA is damaged, DDR begins to work on recuperating the damage th...
  • E3 ubiquitin ligases ubiquitinate target proteins, organism-specific biosystem (from REACTOME)
    E3 ubiquitin ligases ubiquitinate target proteins, organism-specific biosystemE3 ubiquitin ligases catalyze the transfer of an ubiquitin from an E2-ubiquitin conjugate to a target protein. Generally, ubiquitin is transferred via formation of an amide bond to a particular lysin...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Protein ubiquitination, organism-specific biosystem (from REACTOME)
    Protein ubiquitination, organism-specific biosystemUbiquitin is a small, 76 amino acid residue protein that is conjugated by E3 ubiquitin ligases to other proteins in order to regulate their function or degradation (enzymatic cascade reviewed in Neut...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11189, FLJ20382, KIAA2779, MGC129667, MGC129668

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
HULC complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase BRE1A
Names
BRE1 E3 ubiquitin ligase homolog
RING-type E3 ubiquitin transferase BRE1A
homolog of S. cerevisiae BRE1
NP_062538.5
XP_011517164.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047002.1 RefSeqGene

    Range
    5001..34496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_019592.7NP_062538.5  E3 ubiquitin-protein ligase BRE1A

    See identical proteins and their annotated locations for NP_062538.5

    Status: REVIEWED

    Source sequence(s)
    AF265230, AL832910, BC110584
    Consensus CDS
    CCDS35084.1
    UniProtKB/Swiss-Prot
    Q5VTR2
    Related
    ENSP00000373772.3, ENST00000389120.8
    Conserved Domains (2) summary
    cd16704
    Location:920965
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins
    cl25732
    Location:231895
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    101533849..101563344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518862.1XP_011517164.1  E3 ubiquitin-protein ligase BRE1A isoform X1

    See identical proteins and their annotated locations for XP_011517164.1

    UniProtKB/Swiss-Prot
    Q5VTR2
    Conserved Domains (2) summary
    cd16704
    Location:920965
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins
    cl25732
    Location:231895
    SMC_N; RecF/RecN/SMC N terminal domain
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