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PRLR prolactin receptor [ Homo sapiens (human) ]

Gene ID: 5618, updated on 21-Apr-2019

Summary

Official Symbol
PRLRprovided by HGNC
Official Full Name
prolactin receptorprovided by HGNC
Primary source
HGNC:HGNC:9446
See related
Ensembl:ENSG00000113494 MIM:176761
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPRL; MFAB; hPRLrI; RI-PRLR
Summary
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
Expression
Biased expression in placenta (RPKM 18.9), endometrium (RPKM 11.6) and 8 other tissues See more
Orthologs

Genomic context

See PRLR in Genome Data Viewer
Location:
5p13.2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (35048756..35230724, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (35048861..35230823, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene alanine--glyoxylate aminotransferase 2 Neighboring gene RNA, U7 small nuclear 130 pseudogene Neighboring gene uncharacterized LOC105374724 Neighboring gene sperm flagellar 2 Neighboring gene interleukin 7 receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • ErbB4 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    ErbB4 signaling events, organism-specific biosystem
    ErbB4 signaling events
  • Growth hormone receptor signaling, organism-specific biosystem (from REACTOME)
    Growth hormone receptor signaling, organism-specific biosystemGrowth hormone (Somatotropin or GH) is a key factor in determining lean body mass, stimulating the growth and metabolism of muscle, bone and cartilage cells, while reducing body fat. It has many othe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
    Ovarian Infertility Genes, organism-specific biosystemOvarian bottleneck genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility ph...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...
  • Prolactin receptor signaling, organism-specific biosystem (from REACTOME)
    Prolactin receptor signaling, organism-specific biosystemProlactin (PRL) is a hormone secreted mainly by the anterior pituitary gland. It was originally identified by its ability to stimulate the development of the mammary gland and lactation, but is now k...
  • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
    Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
  • Prolactin signaling pathway, conserved biosystem (from KEGG)
    Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
  • Signaling events mediated by PTP1B, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by PTP1B, organism-specific biosystem
    Signaling events mediated by PTP1B

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
ornithine decarboxylase activator activity NAS
Non-traceable Author Statement
more info
PubMed 
peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
prolactin receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
JAK-STAT cascade involved in growth hormone signaling pathway TAS
Traceable Author Statement
more info
 
T cell activation NAS
Non-traceable Author Statement
more info
PubMed 
activation of Janus kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
activation of transmembrane receptor protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
embryo implantation TAS
Traceable Author Statement
more info
PubMed 
lactation NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
prolactin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
steroid biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endosome lumen TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prolactin receptor
Names
hPRL receptor
secreted prolactin binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029042.2 RefSeqGene

    Range
    5133..180025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000949.7NP_000940.1  prolactin receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_000940.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1, also known as long form).
    Source sequence(s)
    AC010368, AI079645, AK313270, BP357907, KF573643
    Consensus CDS
    CCDS3909.1
    UniProtKB/Swiss-Prot
    P16471
    Related
    ENSP00000482954.1, ENST00000618457.5
    Conserved Domains (3) summary
    cd00063
    Location:127225
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:286362
    GHBP; Growth hormone receptor binding
    cl21522
    Location:24120
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_001204314.2NP_001191243.1  prolactin receptor isoform 6 precursor

    See identical proteins and their annotated locations for NP_001191243.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two in-frame coding exons compared to variant 1. This results in a shorter isoform (6, also known as deltaS1) missing an internal protein segment coding for the S1 motif, compared to isoform 1. This isoform has been shown to be expressed at the protein level on the cell surface, and is functional (PMID:12351696).
    Source sequence(s)
    AC010368, AF349939, AI079645, DA640476, KF573643
    Consensus CDS
    CCDS56358.1
    UniProtKB/Swiss-Prot
    P16471
    Related
    ENSP00000482689.1, ENST00000620785.4
    Conserved Domains (2) summary
    cd00063
    Location:26124
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:185261
    GHBP; Growth hormone receptor binding
  3. NM_001204315.1NP_001191244.1  prolactin receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001191244.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is alternatively spliced at the 3' end compared to variant 1. This results in a frame-shift and a shorter isoform (2, also known as intermediate form) with a distinct C-terminus compared to isoform 1. This isoform is functional, but has different tissue specific expression and signaling pattern from isoform 1 (PMID:10585417).
    Source sequence(s)
    AF166329, M31661
    Consensus CDS
    CCDS56362.1
    UniProtKB/Swiss-Prot
    P16471
    Related
    ENSP00000484768.1, ENST00000619676.4
    Conserved Domains (2) summary
    cd00063
    Location:127225
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:24120
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. NM_001204316.1NP_001191245.1  prolactin receptor isoform 3 precursor

    See identical proteins and their annotated locations for NP_001191245.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (3, also known as SF1a for short form 1a) with a distinct C-terminus compared to isoform 1. This isoform is functional with a dominant-negative effect on the function of isoform 1 (PMID:12580759).
    Source sequence(s)
    AF416619, M31661
    Consensus CDS
    CCDS56361.1
    UniProtKB/Swiss-Prot
    P16471
    Related
    ENSP00000441813.2, ENST00000542609.5
    Conserved Domains (2) summary
    cd00063
    Location:127225
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:24120
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  5. NM_001204317.1NP_001191246.1  prolactin receptor isoform 4 precursor

    See identical proteins and their annotated locations for NP_001191246.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is missing an exon at the 3' end, and contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (4, also known as SF1b for short form 1b) with a distinct C-terminus compared to isoform 1. This isoform is functional with a strong dominant-negative effect on the function of isoform 1 (PMID:12580759).
    Source sequence(s)
    AF416618, M31661
    Consensus CDS
    CCDS56360.1
    UniProtKB/Swiss-Prot
    P16471
    Related
    ENSP00000425300.2, ENST00000509140.5
    Conserved Domains (2) summary
    cd00063
    Location:127225
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:24120
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  6. NM_001204318.1NP_001191247.1  prolactin receptor isoform 5 precursor

    See identical proteins and their annotated locations for NP_001191247.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) is missing 3 consecutive exons, and contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (5, also known as delta 7/11) with a distinct C-terminus compared to isoform 1. This isoform, lacking a transmembrane domain, but containing a complete extracellular binding domain, was shown to be a secreted, prolactin-binding protein (PMID:12580759).
    Source sequence(s)
    AF416619, M31661
    Consensus CDS
    CCDS56359.1
    UniProtKB/Swiss-Prot
    P16471
    Related
    ENSP00000422935.2, ENST00000514088.5
    Conserved Domains (2) summary
    cd00063
    Location:127225
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:24120
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. NR_037910.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks two non-consecutive exons, and contains an alternate 3' terminal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF416619, AF493069, M31661
    Related
    ENST00000618625.4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    35048756..35230724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446131.1XP_024301899.1  prolactin receptor isoform X1

    Conserved Domains (3) summary
    cd00063
    Location:161259
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:320396
    GHBP; Growth hormone receptor binding
    cl21522
    Location:58154
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_017009645.1XP_016865134.1  prolactin receptor isoform X3

  3. XM_024446132.1XP_024301900.1  prolactin receptor isoform X2

    Conserved Domains (3) summary
    cd00063
    Location:127225
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:286362
    GHBP; Growth hormone receptor binding
    cl21522
    Location:24120
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. XM_006714484.2XP_006714547.1  prolactin receptor isoform X2

    See identical proteins and their annotated locations for XP_006714547.1

    UniProtKB/Swiss-Prot
    P16471
    Conserved Domains (3) summary
    cd00063
    Location:127225
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:286362
    GHBP; Growth hormone receptor binding
    cl21522
    Location:24120
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  5. XM_011514068.2XP_011512370.1  prolactin receptor isoform X2

    See identical proteins and their annotated locations for XP_011512370.1

    UniProtKB/Swiss-Prot
    P16471
    Conserved Domains (3) summary
    cd00063
    Location:127225
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:286362
    GHBP; Growth hormone receptor binding
    cl21522
    Location:24120
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  6. XM_011514069.2XP_011512371.1  prolactin receptor isoform X2

    See identical proteins and their annotated locations for XP_011512371.1

    UniProtKB/Swiss-Prot
    P16471
    Conserved Domains (3) summary
    cd00063
    Location:127225
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12772
    Location:286362
    GHBP; Growth hormone receptor binding
    cl21522
    Location:24120
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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