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PRCP prolylcarboxypeptidase [ Homo sapiens (human) ]

Gene ID: 5547, updated on 3-Dec-2024

Summary

Official Symbol
PRCPprovided by HGNC
Official Full Name
prolylcarboxypeptidaseprovided by HGNC
Primary source
HGNC:HGNC:9344
See related
Ensembl:ENSG00000137509 MIM:176785; AllianceGenome:HGNC:9344
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCP; HUMPCP
Summary
This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in placenta (RPKM 42.6), urinary bladder (RPKM 37.6) and 25 other tissues See more
Orthologs
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Genomic context

See PRCP in Genome Data Viewer
Location:
11q14.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (82822936..82901644, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (82759396..82838151, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (82533978..82612686, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 181 member B Neighboring gene long intergenic non-protein coding RNA 2734 Neighboring gene RBMX pseudogene 3 Neighboring gene small nucleolar RNA U13 Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 6 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:82569102-82570301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5333 Neighboring gene MIR3 retrotransposon enhancer-blocking element Neighboring gene uncharacterized LOC124902602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3817 Neighboring gene DNA damage induced apoptosis suppressor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3818 Neighboring gene ribosomal protein L7a pseudogene 54

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC2202

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in angiogenesis involved in wound healing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in energy homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in plasma kallikrein-kinin cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of blood vessel endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of thyroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lysosomal Pro-X carboxypeptidase
Names
angiotensinase C
lysosomal carboxypeptidase C
proline carboxypeptidase
NP_001306143.1
NP_005031.1
NP_955450.2
XP_005274150.1
XP_054225298.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319214.2NP_001306143.1  lysosomal Pro-X carboxypeptidase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus and lacks a predicted signal peptide compared to isoform 1.
    Source sequence(s)
    AA477618, AK302386, AP001646, AW627417, BC001500, BE154586, CB154314
    Consensus CDS
    CCDS91553.1
    UniProtKB/TrEMBL
    B7Z7Q6, E9PIG4, E9PNF7, E9PR42
    Related
    ENSP00000436095.2, ENST00000534264.2
    Conserved Domains (1) summary
    cl21494
    Location:1372
    Abhydrolase; alpha/beta hydrolases
  2. NM_005040.4NP_005031.1  lysosomal Pro-X carboxypeptidase isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_005031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AA477618, AP001646, AW627417, BC001500, BE154586, BI827978, CB154314
    Consensus CDS
    CCDS8262.1
    UniProtKB/Swiss-Prot
    A8MU24, B2R7B7, B3KRK5, B5BU34, P42785
    UniProtKB/TrEMBL
    E9PNF7
    Related
    ENSP00000317362.3, ENST00000313010.8
    Conserved Domains (2) summary
    COG0596
    Location:104214
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:55477
    Abhydrolase; alpha/beta hydrolases
  3. NM_199418.4NP_955450.2  lysosomal Pro-X carboxypeptidase isoform 2 precursor

    See identical proteins and their annotated locations for NP_955450.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is longer than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AA477618, AK091786, AP001646, AW627417, BC001500, BE154586, CB154314
    Consensus CDS
    CCDS41695.1
    UniProtKB/TrEMBL
    E9PNF7
    Related
    ENSP00000377055.2, ENST00000393399.6
    Conserved Domains (2) summary
    COG0596
    Location:125235
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:78498
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    82822936..82901644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274093.2XP_005274150.1  lysosomal Pro-X carboxypeptidase isoform X1

    See identical proteins and their annotated locations for XP_005274150.1

    UniProtKB/TrEMBL
    B7Z7Q6, E9PIG4, E9PNF7, E9PR42
    Related
    ENSP00000505064.1, ENST00000680566.1
    Conserved Domains (1) summary
    cl21494
    Location:1372
    Abhydrolase; alpha/beta hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    82759396..82838151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369323.1XP_054225298.1  lysosomal Pro-X carboxypeptidase isoform X1

    UniProtKB/TrEMBL
    B7Z7Q6, E9PIG4, E9PNF7, E9PR42