STX17 syntaxin 17 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STX17provided by HGNC
Official Full Name: syntaxin 17provided by HGNC
Primary source: HGNC:HGNC:11432
See related: Ensembl:ENSG00000136874 MIM:604204; AllianceGenome:HGNC:11432
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Enables SNAP receptor activity; SNARE binding activity; and protein phosphatase binding activity. Involved in several processes, including autophagosome membrane docking; endoplasmic reticulum to Golgi vesicle-mediated transport; and endoplasmic reticulum-Golgi intermediate compartment organization. Acts upstream of or within protein localization to phagophore assembly site. Located in several cellular components, including autophagosome membrane; endoplasmic reticulum-Golgi intermediate compartment; and mitochondria-associated endoplasmic reticulum membrane contact site. Part of SNARE complex. [provided by Alliance of Genome Resources, Apr 2025]
Expression: Ubiquitous expression in thyroid (RPKM 7.7), skin (RPKM 7.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q31.1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (99906654..99974534)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (112078304..112146158)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (102668936..102736816)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation.
Title: Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation.
Exacerbation of atherosclerosis by STX17 knockdown: Unravelling the role of autophagy and inflammation.
Title: Exacerbation of atherosclerosis by STX17 knockdown: Unravelling the role of autophagy and inflammation.
SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma.
Title: SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma.
Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion.
Title: Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion.
The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.
Title: The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.
ULK phosphorylation of STX17 controls autophagosome maturation via FLNA.
Title: ULK phosphorylation of STX17 controls autophagosome maturation via FLNA.
Acetylation of STX17 (syntaxin 17) controls autophagosome maturation.
Title: Acetylation of STX17 (syntaxin 17) controls autophagosome maturation.
Long non-coding RNA XIST confers aggressive progression via miR-361-3p/STX17 in retinoblastoma cells.
Title: Long non-coding RNA XIST confers aggressive progression via miR-361-3p/STX17 in retinoblastoma cells.
A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress.
Title: A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress.
Circular RNA circ_0000034 upregulates STX17 level to promote human retinoblastoma development via inhibiting miR-361-3p.
Title: Circular RNA circ_0000034 upregulates STX17 level to promote human retinoblastoma development via inhibiting miR-361-3p.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484372

D11S3017 (e-PCR)
- UniSTS:152121

D11S3026 (e-PCR)
- UniSTS:152129

RH93873 (e-PCR)
- UniSTS:85849

RH80962 (e-PCR)
- UniSTS:93052

STS-T98624 (e-PCR)
- UniSTS:19582

G02304 (e-PCR)
- UniSTS:4742

STS-F10187 (e-PCR)
- UniSTS:64150

D11S2766 (e-PCR)
- UniSTS:151969

RH47955 (e-PCR)
- UniSTS:11682

G29237 (e-PCR)
- UniSTS:64944

NoName (e-PCR)
- UniSTS:62643

D11S3270 (e-PCR)
- UniSTS:152513

STX17_9865 (e-PCR)
- UniSTS:468725

Clone Names

FLJ20651, MGC102796, MGC126613, MGC126615

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNAP receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IDA Inferred from Direct Assay more info	PubMed
enables SNARE binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagosome maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome membrane docking	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagosome-lysosome fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum-Golgi intermediate compartment organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in COPII-coated ER to Golgi transport vesicle	IEA Inferred from Electronic Annotation more info
located_in COPII-coated ER to Golgi transport vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in ER to Golgi transport vesicle membrane	IEA Inferred from Electronic Annotation more info
part_of HOPS complex	IDA Inferred from Direct Assay more info	PubMed
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	IDA Inferred from Direct Assay more info	PubMed
located_in autolysosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
located_in autophagosome	IEA Inferred from Electronic Annotation more info
is_active_in autophagosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in autophagosome membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum-Golgi intermediate compartment	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
NOT located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HTP more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
NOT located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
NOT located_in rough endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in smooth endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in smooth endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: syntaxin-17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017919.3 → NP_060389.2 syntaxin-17

See identical proteins and their annotated locations for NP_060389.2

Status: VALIDATED

Source sequence(s)

AI375996, AL358937, BC101566, DC318495

Consensus CDS

CCDS6745.1

UniProtKB/Swiss-Prot

P56962, Q4VXC2

UniProtKB/TrEMBL

B3KTA5, Q2TAB5

Related

ENSP00000259400.6, ENST00000259400.11

Conserved Domains (2) summary

COG5325
Location:2 → 228

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15846
Location:162 → 223

SNARE_syntaxin17; SNARE motif of syntaxin 17