U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PODXL podocalyxin like [ Homo sapiens (human) ]

Gene ID: 5420, updated on 7-Apr-2024

Summary

Official Symbol
PODXLprovided by HGNC
Official Full Name
podocalyxin likeprovided by HGNC
Primary source
HGNC:HGNC:9171
See related
Ensembl:ENSG00000128567 MIM:602632; AllianceGenome:HGNC:9171
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PC; PDX; PCLP; Gp200; gp135; PCLP-1; PODXL1
Summary
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 88.8), lung (RPKM 31.4) and 19 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PODXL in Genome Data Viewer
Location:
7q32.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (131500271..131556628, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (132817863..132874188, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (131185030..131241387, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene muskelin 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131012400-131012976 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131012977-131013553 Neighboring gene uncharacterized LOC124901747 Neighboring gene MKLN1 antisense RNA Neighboring gene ReSE screen-validated silencer GRCh37_chr7:131070963-131071136 Neighboring gene MPRA-validated peak6726 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr7:131123760-131124261 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131190418-131191332 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18662 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131198033-131198892 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:131202395-131202894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:131214845-131215344 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131220834-131221758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131229138-131229981 Neighboring gene ribosomal protein L31 pseudogene 36 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:131235953-131236460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:131236969-131237476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18663 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131241775-131242322 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131266468-131267072 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:131269032-131269532 Neighboring gene MPRA-validated peak6728 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:131277274-131277774 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131289409-131290262 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131290263-131291118 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131291119-131291972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131305309-131305854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131308691-131309358 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131309359-131310024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131323052-131323648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:131333987-131334690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131337191-131337758 Neighboring gene Sharpr-MPRA regulatory regions 8940 and 15248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:131340839-131341390 Neighboring gene eukaryotic translation elongation factor 1 beta 2 pseudogene 6 Neighboring gene ribosomal protein S14 pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC138240

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in epithelial tube formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in podocyte development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell-cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell-cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of microvillus assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of microvillus assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space HDA PubMed 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
is_active_in microvillus membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microvillus membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
located_in slit diaphragm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
podocalyxin
Names
GCTM-2 antigen
podocalyxin-like protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042104.1 RefSeqGene

    Range
    4990..61347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018111.3NP_001018121.1  podocalyxin isoform 1 precursor

    See identical proteins and their annotated locations for NP_001018121.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC008264, AK055816, AK223573, BC042466, BP355358, CN290641
    Consensus CDS
    CCDS34755.1
    UniProtKB/Swiss-Prot
    A6NHX8, O00592, Q52LZ7, Q53ER6
    UniProtKB/TrEMBL
    B7ZKQ8
    Related
    ENSP00000367817.3, ENST00000378555.8
    Conserved Domains (1) summary
    pfam06365
    Location:358557
    CD34_antigen; CD34/Podocalyxin family
  2. NM_005397.4NP_005388.2  podocalyxin isoform 2 precursor

    See identical proteins and their annotated locations for NP_005388.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame alternate exon compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AC008264, AK055816, AK223573, BC042466, BP355358
    Consensus CDS
    CCDS47714.1
    UniProtKB/TrEMBL
    Q96N83
    Related
    ENSP00000319782.9, ENST00000322985.9
    Conserved Domains (2) summary
    pfam06365
    Location:326525
    CD34_antigen; CD34/Podocalyxin family
    cl25496
    Location:33293
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    131500271..131556628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    132817863..132874188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)