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SERPINA4 serpin family A member 4 [ Homo sapiens (human) ]

Gene ID: 5267, updated on 12-May-2019

Summary

Official Symbol
SERPINA4provided by HGNC
Official Full Name
serpin family A member 4provided by HGNC
Primary source
HGNC:HGNC:8948
See related
Ensembl:ENSG00000100665 MIM:147935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAL; KST; PI4; KLST; PI-4; kallistatin
Expression
Biased expression in liver (RPKM 98.1), gall bladder (RPKM 28.7) and 2 other tissues See more
Orthologs

Genomic context

See SERPINA4 in Genome Data Viewer
Location:
14q32.13
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (94561420..94569913)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (95027779..95036243)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene serpin family A member 9 Neighboring gene serpin family A member 12 Neighboring gene serpin family A member 5 Neighboring gene uncharacterized LOC112268127 Neighboring gene serpin family A member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet dense granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
kallistatin
Names
kallikrein inhibitor
peptidase inhibitor 4
protease inhibitor 4 (kallistatin)
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin A4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
sserpin family A member 4
testicular secretory protein Li 22

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289032.1NP_001275961.1  kallistatin isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI273449, AK309586, BC014992, DA036536
    UniProtKB/Swiss-Prot
    P29622
    Conserved Domains (1) summary
    cd02056
    Location:91458
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
  2. NM_001289033.1NP_001275962.1  kallistatin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001275962.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' region, which results in translation initiation at a downstream AUG codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform 2.
    Source sequence(s)
    AI273449, BC014992, BX248009, DA036536, DA637776
    Consensus CDS
    CCDS9927.1
    UniProtKB/Swiss-Prot
    P29622
    UniProtKB/TrEMBL
    A0A024R6I9
    Related
    ENSP00000298841.5, ENST00000298841.5
    Conserved Domains (1) summary
    cd02056
    Location:54421
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
  3. NM_006215.4NP_006206.2  kallistatin isoform 2 precursor

    See identical proteins and their annotated locations for NP_006206.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 5' region, which results in translation initiation at a downstream AUG codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform 2.
    Source sequence(s)
    BC014992, BX248760, DA036536
    Consensus CDS
    CCDS9927.1
    UniProtKB/Swiss-Prot
    P29622
    UniProtKB/TrEMBL
    A0A024R6I9
    Related
    ENSP00000450838.1, ENST00000557004.6
    Conserved Domains (1) summary
    cd02056
    Location:54421
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    94561420..94569913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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