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PGGT1B protein geranylgeranyltransferase type I subunit beta [ Homo sapiens (human) ]

Gene ID: 5229, updated on 15-Apr-2019

Summary

Official Symbol
PGGT1Bprovided by HGNC
Official Full Name
protein geranylgeranyltransferase type I subunit betaprovided by HGNC
Primary source
HGNC:HGNC:8895
See related
Ensembl:ENSG00000164219 MIM:602031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BGGI; GGTI
Summary
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]
Expression
Ubiquitous expression in colon (RPKM 3.0), spleen (RPKM 2.3) and 25 other tissues See more
Orthologs

Genomic context

See PGGT1B in Genome Data Viewer
Location:
5q22.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (115200247..115262887, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (114546527..114599123, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927078 Neighboring gene long intergenic non-protein coding RNA 1957 Neighboring gene tripartite motif containing 36 Neighboring gene ribosomal protein S2 pseudogene 26 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 15 Neighboring gene coiled-coil domain containing 112

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat FITC-labeled Tat 47-59 peptide downregulates gene expression of protein geranylgeranyltransferase type I, beta subunit (PGGT1B) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to CAAX-protein geranylgeranyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CAAX-protein geranylgeranyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
drug binding IEA
Inferred from Electronic Annotation
more info
 
isoprenoid binding IEA
Inferred from Electronic Annotation
more info
 
peptide binding IEA
Inferred from Electronic Annotation
more info
 
protein geranylgeranyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
negative regulation of nitric-oxide synthase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
protein geranylgeranylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein geranylgeranylation IDA
Inferred from Direct Assay
more info
PubMed 
protein prenylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to cytokine IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
CAAX-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CAAX-protein geranylgeranyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
geranylgeranyl transferase type-1 subunit beta
Names
CTC-428G20.3
GGTase-I-beta
geranylgeranyl transferase type I subunit beta
geranylgeranyltransferase type I beta subunit
protein geranylgeranyltransferase type I, beta subunit
type I protein geranyl-geranyltransferase subunit beta
NP_005014.2
XP_005272077.2
XP_011541792.1
XP_011541794.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005023.4NP_005014.2  geranylgeranyl transferase type-1 subunit beta

    See identical proteins and their annotated locations for NP_005014.2

    Status: VALIDATED

    Source sequence(s)
    AC008494, AL520655, AW382606, DA024020
    Consensus CDS
    CCDS4116.1
    UniProtKB/Swiss-Prot
    P53609
    Related
    ENSP00000404676.1, ENST00000419445.6
    Conserved Domains (1) summary
    cd02895
    Location:22332
    GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    115200247..115262887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272020.3XP_005272077.2  geranylgeranyl transferase type-1 subunit beta isoform X2

    See identical proteins and their annotated locations for XP_005272077.2

    Conserved Domains (1) summary
    cd02895
    Location:22332
    GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...
  2. XM_011543490.2XP_011541792.1  geranylgeranyl transferase type-1 subunit beta isoform X1

    Conserved Domains (2) summary
    COG5029
    Location:21342
    CAL1; Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]
    cd02895
    Location:22332
    GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...
  3. XM_011543492.2XP_011541794.1  geranylgeranyl transferase type-1 subunit beta isoform X3

    Conserved Domains (1) summary
    cd02895
    Location:1209
    GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...

RNA

  1. XR_001742121.1 RNA Sequence

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