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TMEM8B transmembrane protein 8B [ Homo sapiens (human) ]

Gene ID: 51754, updated on 2-Nov-2024

Summary

Official Symbol
TMEM8Bprovided by HGNC
Official Full Name
transmembrane protein 8Bprovided by HGNC
Primary source
HGNC:HGNC:21427
See related
Ensembl:ENSG00000137103 MIM:616888; AllianceGenome:HGNC:21427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAG5; NGX6; FP588; NAG-5; NGX6a; C9orf127; LINC00950
Summary
Involved in cell-matrix adhesion. Located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 4.5), ovary (RPKM 3.3) and 23 other tissues See more
Orthologs
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Genomic context

See TMEM8B in Genome Data Viewer
Location:
9p13.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (35829228..35865515)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (35849899..35886190)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35829225..35865512)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19882 Neighboring gene histidine triad nucleotide binding protein 2 Neighboring gene family with sequence similarity 221 member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:35829817-35830317 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:35835675-35836588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28340 Neighboring gene Sharpr-MPRA regulatory region 825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:35846373-35847248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28343 Neighboring gene olfactory receptor family 13 subfamily E member 1 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:35865013-35865512 Neighboring gene olfactory receptor family 13 subfamily J member 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ30363, FLJ30741, MGC120460, DKFZp547N0218

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane protein 8B
Names
nasopharyngeal carcinoma expressed 6
nasopharyngeal carcinoma related protein
nasopharyngeal carcinoma-associated gene 6 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042589.3NP_001036054.1  transmembrane protein 8B isoform a

    See identical proteins and their annotated locations for NP_001036054.1

    Status: VALIDATED

    Source sequence(s)
    AL133410, BC043384
    Consensus CDS
    CCDS43800.1
    UniProtKB/Swiss-Prot
    A6NDV4, B3KQF3, O75539, Q49AB1, Q4KMX5, Q5TCW5, Q9HBY2, Q9P0U7
    Related
    ENSP00000367230.4, ENST00000377991.9
    Conserved Domains (1) summary
    pfam12036
    Location:245415
    DUF3522; Protein of unknown function (DUF3522)
  2. NM_001042590.4NP_001036055.2  transmembrane protein 8B isoform c

    Status: VALIDATED

    Source sequence(s)
    AL133410
    Consensus CDS
    CCDS94406.1
    UniProtKB/TrEMBL
    A0A2R8Y2M5
    Related
    ENSP00000493496.1, ENST00000643932.2
    Conserved Domains (2) summary
    pfam12036
    Location:697867
    DUF3522; Protein of unknown function (DUF3522)
    cl26464
    Location:34144
    Atrophin-1; Atrophin-1 family
  3. NM_001363620.1NP_001350549.1  transmembrane protein 8B isoform d

    Status: VALIDATED

    Source sequence(s)
    AL133410
    Conserved Domains (2) summary
    pfam12036
    Location:697751
    DUF3522; Protein of unknown function (DUF3522)
    cl26464
    Location:34144
    Atrophin-1; Atrophin-1 family
  4. NM_001363621.1NP_001350550.1  transmembrane protein 8B isoform b

    Status: VALIDATED

    Source sequence(s)
    AL133410
    Consensus CDS
    CCDS6595.1
    Related
    ENSP00000367235.1, ENST00000377996.5
    Conserved Domains (1) summary
    pfam12036
    Location:245299
    DUF3522; Protein of unknown function (DUF3522)
  5. NM_001363622.1NP_001350551.1  transmembrane protein 8B isoform e

    Status: VALIDATED

    Source sequence(s)
    AL133410
    Conserved Domains (1) summary
    pfam12036
    Location:245361
    DUF3522; Protein of unknown function (DUF3522)
  6. NM_001363625.1NP_001350554.1  transmembrane protein 8B isoform f

    Status: VALIDATED

    Source sequence(s)
    AL133410, BC064951
    Conserved Domains (1) summary
    cl26464
    Location:34144
    Atrophin-1; Atrophin-1 family
  7. NM_016446.4NP_057530.2  transmembrane protein 8B isoform b

    See identical proteins and their annotated locations for NP_057530.2

    Status: VALIDATED

    Source sequence(s)
    AF188239, AL133410
    Consensus CDS
    CCDS6595.1
    UniProtKB/Swiss-Prot
    A6NDV4
    Related
    ENSP00000395810.2, ENST00000439587.6
    Conserved Domains (1) summary
    pfam12036
    Location:245299
    DUF3522; Protein of unknown function (DUF3522)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    35829228..35865515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517902.3XP_011516204.2  transmembrane protein 8B isoform X2

  2. XM_047423472.1XP_047279428.1  transmembrane protein 8B isoform X15

    UniProtKB/Swiss-Prot
    A6NDV4, B3KQF3, O75539, Q49AB1, Q4KMX5, Q5TCW5, Q9HBY2, Q9P0U7
  3. XM_011517901.3XP_011516203.2  transmembrane protein 8B isoform X1

  4. XM_011517903.3XP_011516205.2  transmembrane protein 8B isoform X4

  5. XM_005251483.5XP_005251540.4  transmembrane protein 8B isoform X3

  6. XM_024447570.2XP_024303338.2  transmembrane protein 8B isoform X5

  7. XM_047423467.1XP_047279423.1  transmembrane protein 8B isoform X8

  8. XM_047423468.1XP_047279424.1  transmembrane protein 8B isoform X11

  9. XM_011517912.3XP_011516214.1  transmembrane protein 8B isoform X10

    See identical proteins and their annotated locations for XP_011516214.1

    Conserved Domains (1) summary
    pfam12036
    Location:271383
    DUF3522; Protein of unknown function (DUF3522)
  10. XM_011517910.4XP_011516212.1  transmembrane protein 8B isoform X10

    See identical proteins and their annotated locations for XP_011516212.1

    Conserved Domains (1) summary
    pfam12036
    Location:271383
    DUF3522; Protein of unknown function (DUF3522)
  11. XM_047423466.1XP_047279422.1  transmembrane protein 8B isoform X7

  12. XM_011517905.2XP_011516207.2  transmembrane protein 8B isoform X6

  13. XM_047423470.1XP_047279426.1  transmembrane protein 8B isoform X13

  14. XM_047423469.1XP_047279425.1  transmembrane protein 8B isoform X12

  15. XM_011517913.3XP_011516215.1  transmembrane protein 8B isoform X10

    See identical proteins and their annotated locations for XP_011516215.1

    Conserved Domains (1) summary
    pfam12036
    Location:271383
    DUF3522; Protein of unknown function (DUF3522)
  16. XM_011517914.3XP_011516216.1  transmembrane protein 8B isoform X10

    See identical proteins and their annotated locations for XP_011516216.1

    Conserved Domains (1) summary
    pfam12036
    Location:271383
    DUF3522; Protein of unknown function (DUF3522)
  17. XM_047423471.1XP_047279427.1  transmembrane protein 8B isoform X14

  18. XM_017014805.2XP_016870294.1  transmembrane protein 8B isoform X9

    Conserved Domains (1) summary
    pfam12036
    Location:438550
    DUF3522; Protein of unknown function (DUF3522)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    35849899..35886190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363088.1XP_054219063.1  transmembrane protein 8B isoform X2

  2. XM_054363105.1XP_054219080.1  transmembrane protein 8B isoform X15

    UniProtKB/Swiss-Prot
    A6NDV4, B3KQF3, O75539, Q49AB1, Q4KMX5, Q5TCW5, Q9HBY2, Q9P0U7
  3. XM_054363107.1XP_054219082.1  transmembrane protein 8B isoform X15

    UniProtKB/Swiss-Prot
    A6NDV4, B3KQF3, O75539, Q49AB1, Q4KMX5, Q5TCW5, Q9HBY2, Q9P0U7
  4. XM_054363090.1XP_054219065.1  transmembrane protein 8B isoform X4

  5. XM_054363091.1XP_054219066.1  transmembrane protein 8B isoform X5

  6. XM_054363098.1XP_054219073.1  transmembrane protein 8B isoform X11

  7. XM_054363087.1XP_054219062.1  transmembrane protein 8B isoform X1

  8. XM_054363089.1XP_054219064.1  transmembrane protein 8B isoform X3

  9. XM_054363094.1XP_054219069.1  transmembrane protein 8B isoform X8

  10. XM_054363097.1XP_054219072.1  transmembrane protein 8B isoform X10

  11. XM_054363096.1XP_054219071.1  transmembrane protein 8B isoform X10

  12. XM_054363101.1XP_054219076.1  transmembrane protein 8B isoform X10

  13. XM_054363102.1XP_054219077.1  transmembrane protein 8B isoform X10

  14. XM_054363093.1XP_054219068.1  transmembrane protein 8B isoform X7

  15. XM_054363092.1XP_054219067.1  transmembrane protein 8B isoform X6

  16. XM_054363100.1XP_054219075.1  transmembrane protein 8B isoform X13

  17. XM_054363099.1XP_054219074.1  transmembrane protein 8B isoform X12

  18. XM_054363103.1XP_054219078.1  transmembrane protein 8B isoform X10

  19. XM_054363106.1XP_054219081.1  transmembrane protein 8B isoform X10

  20. XM_054363104.1XP_054219079.1  transmembrane protein 8B isoform X14

  21. XM_054363095.1XP_054219070.1  transmembrane protein 8B isoform X9

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_024006.1: Suppressed sequence

    Description
    NR_024006.1: This RefSeq was removed because the gene was discontinued.