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NUB1 negative regulator of ubiquitin like proteins 1 [ Homo sapiens (human) ]

Gene ID: 51667, updated on 13-Feb-2019

Summary

Official Symbol
NUB1provided by HGNC
Official Full Name
negative regulator of ubiquitin like proteins 1provided by HGNC
Primary source
HGNC:HGNC:17623
See related
Ensembl:ENSG00000013374 MIM:607981
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BS4; NUB1L; NYREN18
Summary
This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in lymph node (RPKM 24.3), testis (RPKM 24.2) and 25 other tissues See more
Orthologs

Genomic context

See NUB1 in Genome Data Viewer
Location:
7q36.1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (151341699..151378461)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (151038785..151075547)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene chondroitin polymerizing factor 2 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Neighboring gene microRNA 671 Neighboring gene WD repeat domain 86 Neighboring gene WDR86 antisense RNA 1 Neighboring gene microRNA 3907 Neighboring gene crystallin gamma N

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular negative regulator of ubiquitin-like protein 1 (NUB1) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to interferon-gamma IEP
Inferred from Expression Pattern
more info
PubMed 
response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NEDD8 ultimate buster 1
Names
NEDD8 ultimate buster-1
renal carcinoma antigen NY-REN-18

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029746.2 RefSeqGene

    Range
    5001..41701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243351.1NP_001230280.1  NEDD8 ultimate buster 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (2, also known as NUB1L).
    Source sequence(s)
    AC005486, AF300717, AF459743, AW205479, BC046354, DB048887
    Consensus CDS
    CCDS59089.1
    UniProtKB/Swiss-Prot
    Q9Y5A7
    UniProtKB/TrEMBL
    H3BM74
    Related
    ENSP00000454264.1, ENST00000568733.5
    Conserved Domains (3) summary
    cd14291
    Location:400435
    UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cd14292
    Location:459492
    UBA2_NUB1; UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cl21463
    Location:517552
    UBA_like_SF; UBA domain-like superfamily
  2. NM_001363529.1NP_001350458.1  NEDD8 ultimate buster 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC005486
    Consensus CDS
    CCDS87565.1
    Conserved Domains (4) summary
    cd14291
    Location:376411
    UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cd14292
    Location:435468
    UBA2_NUB1; UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cl21463
    Location:493528
    UBA_like_SF; UBA domain-like superfamily
    cl26472
    Location:29201
    DUF3084; Protein of unknown function (DUF3084)
  3. NM_016118.4NP_057202.3  NEDD8 ultimate buster 1 isoform 2

    See identical proteins and their annotated locations for NP_057202.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (2, also known as NUB1) that is shorter than isoform 1.
    Source sequence(s)
    AC005486, AF300717, AW205479, AY129295, BC046354, BG105733, DB048887
    Consensus CDS
    CCDS47751.2
    UniProtKB/Swiss-Prot
    Q9Y5A7
    UniProtKB/TrEMBL
    H3BM14
    Related
    ENSP00000398644.2, ENST00000413040.6
    Conserved Domains (2) summary
    cd14291
    Location:400435
    UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cl21463
    Location:503538
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    151341699..151378461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012307.1XP_016867796.1  NEDD8 ultimate buster 1 isoform X6

  2. XM_017012304.1XP_016867793.1  NEDD8 ultimate buster 1 isoform X1

  3. XM_017012305.1XP_016867794.1  NEDD8 ultimate buster 1 isoform X2

  4. XM_017012308.1XP_016867797.1  NEDD8 ultimate buster 1 isoform X7

  5. XM_017012306.1XP_016867795.1  NEDD8 ultimate buster 1 isoform X4

    UniProtKB/Swiss-Prot
    Q9Y5A7
    UniProtKB/TrEMBL
    A0A090N8Q5
    Conserved Domains (2) summary
    cd14291
    Location:376411
    UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cl21463
    Location:479514
    UBA_like_SF; UBA domain-like superfamily
  6. XM_005250011.2XP_005250068.1  NEDD8 ultimate buster 1 isoform X3

    UniProtKB/Swiss-Prot
    Q9Y5A7
    Related
    ENSP00000418234.2, ENST00000470229.6
    Conserved Domains (4) summary
    cd14291
    Location:376411
    UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cd14292
    Location:435468
    UBA2_NUB1; UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cl21463
    Location:493528
    UBA_like_SF; UBA domain-like superfamily
    cl26472
    Location:29201
    DUF3084; Protein of unknown function (DUF3084)
  7. XM_017012309.1XP_016867798.1  NEDD8 ultimate buster 1 isoform X8

  8. XM_024446797.1XP_024302565.1  NEDD8 ultimate buster 1 isoform X5

    Conserved Domains (3) summary
    cd14291
    Location:375410
    UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cl21463
    Location:478513
    UBA_like_SF; UBA domain-like superfamily
    cl26472
    Location:29200
    DUF3084; Protein of unknown function (DUF3084)
  9. XM_024446798.1XP_024302566.1  NEDD8 ultimate buster 1 isoform X9

    Conserved Domains (3) summary
    cd14291
    Location:223258
    UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cd14292
    Location:282315
    UBA2_NUB1; UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cl21463
    Location:340375
    UBA_like_SF; UBA domain-like superfamily
  10. XM_024446799.1XP_024302567.1  NEDD8 ultimate buster 1 isoform X10

    Conserved Domains (2) summary
    cd14291
    Location:223258
    UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cl21463
    Location:326361
    UBA_like_SF; UBA domain-like superfamily
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