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KLF13 Kruppel like factor 13 [ Homo sapiens (human) ]

Gene ID: 51621, updated on 15-Apr-2019

Summary

Official Symbol
KLF13provided by HGNC
Official Full Name
Kruppel like factor 13provided by HGNC
Primary source
HGNC:HGNC:13672
See related
Ensembl:ENSG00000169926 MIM:605328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTEB3; FKLF2; NSLP1; RFLAT1; RFLAT-1
Summary
KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 34.5), lung (RPKM 27.2) and 24 other tissues See more
Orthologs

Genomic context

See KLF13 in Genome Data Viewer
Location:
15q13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (31326855..31435665)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (31619083..31670102)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2352 Neighboring gene uncharacterized LOC283710 Neighboring gene VISTA enhancer hs2231 Neighboring gene uncharacterized LOC105376707 Neighboring gene uncharacterized LOC105370939 Neighboring gene ubiquitin conjugating enzyme E2 C pseudogene 4 Neighboring gene uncharacterized LOC107987220 Neighboring gene REX4 homolog, 3'-5' exonuclease pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
15q13.3 microdeletion syndrome
MedGen: C2677613 OMIM: 612001 GeneReviews: 15q13.3 Microdeletion
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NHGRI GWAS Catalog

Description
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36439, FLJ45109

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Krueppel-like factor 13
Names
BTE-binding protein 3
RANTES factor of late activated T lymphocytes-1
basic transcription element binding protein 3
novel Sp1-like zinc finger transcription factor 1
transcription factor BTEB3
transcription factor NSLP1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302461.1NP_001289390.1  Krueppel-like factor 13 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF132599, AI084187, BX096457
    UniProtKB/Swiss-Prot
    Q9Y2Y9
    Conserved Domains (2) summary
    sd00017
    Location:169191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:167191
    zf-C2H2; Zinc finger, C2H2 type
  2. NM_015995.4NP_057079.2  Krueppel-like factor 13 isoform 1

    See identical proteins and their annotated locations for NP_057079.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC012236, AF132599, AL390127, BC064552, BX474032
    Consensus CDS
    CCDS10025.1
    UniProtKB/Swiss-Prot
    Q9Y2Y9
    UniProtKB/TrEMBL
    X5DNR2
    Related
    ENSP00000302456.3, ENST00000307145.4
    Conserved Domains (4) summary
    COG5048
    Location:162252
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:169191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:227249
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:213236
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    31326855..31435665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_011332701.1 Reference GRCh38.p12 PATCHES

    Range
    3500227..3609057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NT_187660.1 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    3612679..3721509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_033741.1: Suppressed sequence

    Description
    NR_033741.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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