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CRNN cornulin [ Homo sapiens (human) ]

Gene ID: 49860, updated on 13-Feb-2019

Summary

Official Symbol
CRNNprovided by HGNC
Official Full Name
cornulinprovided by HGNC
Primary source
HGNC:HGNC:1230
See related
Ensembl:ENSG00000143536 MIM:611312
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRC1; PDRC1; SEP53; C1orf10
Summary
This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]
Expression
Restricted expression toward esophagus (RPKM 2138.4) See more
Orthologs

Genomic context

See CRNN in Genome Data Viewer
Location:
1q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (152409243..152414274, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152381719..152386750, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene FLG antisense RNA 1 Neighboring gene filaggrin family member 2 Neighboring gene high mobility group nucleosomal binding domain 3 pseudogene 1 Neighboring gene late cornified envelope 5A Neighboring gene cysteine rich C-terminal 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
response to heat IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cornulin
Names
53 kDa putative calcium-binding protein
53 kDa squamous epithelial-induced stress protein
58 kDa heat shock protein
squamous epithelial heat shock protein 53
tumor-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016190.2NP_057274.1  cornulin

    See identical proteins and their annotated locations for NP_057274.1

    Status: REVIEWED

    Source sequence(s)
    AF077831, BC030807, DA420219
    Consensus CDS
    CCDS1010.1
    UniProtKB/Swiss-Prot
    Q9UBG3
    Related
    ENSP00000271835.3, ENST00000271835.3
    Conserved Domains (2) summary
    cd00213
    Location:289
    S-100; S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...
    pfam13499
    Location:2875
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    152409243..152414274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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