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CRNN cornulin [ Homo sapiens (human) ]

Gene ID: 49860, updated on 2-Nov-2024

Summary

Official Symbol
CRNNprovided by HGNC
Official Full Name
cornulinprovided by HGNC
Primary source
HGNC:HGNC:1230
See related
Ensembl:ENSG00000143536 MIM:611312; AllianceGenome:HGNC:1230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRC1; PDRC1; SEP53; C1orf10
Summary
This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]
Expression
Restricted expression toward esophagus (RPKM 2138.4) See more
Orthologs
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Genomic context

See CRNN in Genome Data Viewer
Location:
1q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (152409243..152414263, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (151545792..151550812, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152381719..152386739, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cervical cancer associated DHX9 suppressive transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr1:152350237-152350407 Neighboring gene filaggrin 2 Neighboring gene high mobility group nucleosomal binding domain 3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1732 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:152443806-152444710 Neighboring gene late cornified envelope 5A Neighboring gene cysteine rich C-terminal 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cornulin
Names
53 kDa putative calcium-binding protein
53 kDa squamous epithelial-induced stress protein
58 kDa heat shock protein
squamous epithelial heat shock protein 53
tumor-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016190.3NP_057274.1  cornulin

    See identical proteins and their annotated locations for NP_057274.1

    Status: REVIEWED

    Source sequence(s)
    AF077831, BC030807, DA420219
    Consensus CDS
    CCDS1010.1
    UniProtKB/Swiss-Prot
    B2RE60, Q8N613, Q9UBG3
    UniProtKB/TrEMBL
    A8K5I6
    Related
    ENSP00000271835.3, ENST00000271835.3
    Conserved Domains (2) summary
    cd00213
    Location:289
    S-100; S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...
    pfam13499
    Location:2875
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    152409243..152414263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    151545792..151550812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)