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OPCML opioid binding protein/cell adhesion molecule like [ Homo sapiens (human) ]

Gene ID: 4978, updated on 13-Feb-2019

Summary

Official Symbol
OPCMLprovided by HGNC
Official Full Name
opioid binding protein/cell adhesion molecule likeprovided by HGNC
Primary source
HGNC:HGNC:8143
See related
Ensembl:ENSG00000183715 MIM:600632
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OPCM; OBCAM; IGLON1
Summary
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Expression
Biased expression in brain (RPKM 9.6) and kidney (RPKM 0.2) See more
Orthologs

Genomic context

See OPCML in Genome Data Viewer
Location:
11q25
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (132403361..133532612, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (132284875..133402403, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene neurotrimin Neighboring gene VISTA enhancer hs335 Neighboring gene NTM intronic transcript Neighboring gene uncharacterized LOC105369580 Neighboring gene uncharacterized LOC646522 Neighboring gene spermatogenesis associated 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Neoplasm of ovary
MedGen: C0919267 OMIM: 167000 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study of behavioral disinhibition.
NHGRI GWA Catalog
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
NHGRI GWA Catalog
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
NHGRI GWA Catalog
Genome-wide association of sleep and circadian phenotypes.
NHGRI GWA Catalog
Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
NHGRI GWA Catalog
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
neuron recognition TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
opioid-binding protein/cell adhesion molecule
Names
IgLON family member 1
opioid binding protein/cell adhesion molecule-like preprotein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012107.1 RefSeqGene

    Range
    4897..1122845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012393.2NP_001012393.1  opioid-binding protein/cell adhesion molecule isoform b precursor

    See identical proteins and their annotated locations for NP_001012393.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The encoded isoform (b) is shorter and has a distinct N-terminus compared to isoform c. The encoded isoform (b) may undergo proteolytic processing similar to isoform a.
    Source sequence(s)
    AP000843, BC143946, BX537377, DA247864, DC332150
    Consensus CDS
    CCDS31722.1
    UniProtKB/Swiss-Prot
    Q14982
    Related
    ENSP00000434750.1, ENST00000524381.5
    Conserved Domains (3) summary
    smart00409
    Location:227305
    IG; Immunoglobulin
    pfam13927
    Location:128199
    Ig_3; Immunoglobulin domain
    cl11960
    Location:37125
    Ig; Immunoglobulin domain
  2. NM_001319103.1NP_001306032.1  opioid-binding protein/cell adhesion molecule isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c). The encoded isoform (c) may undergo proteolytic processing similar to isoform a.
    Source sequence(s)
    AK314077, AP000843, BC143946, DA247864
    UniProtKB/Swiss-Prot
    Q14982
    Related
    ENSP00000445496.1, ENST00000541867.5
    Conserved Domains (3) summary
    smart00410
    Location:234312
    IG_like; Immunoglobulin like
    pfam13927
    Location:135206
    Ig_3; Immunoglobulin domain
    cl11960
    Location:44132
    Ig; Immunoglobulin domain
  3. NM_001319104.1NP_001306033.1  opioid-binding protein/cell adhesion molecule isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The encoded isoform (d) is shorter, has a distinct N-terminus, and lacks a predicted signal peptide compared to isoform c.
    Source sequence(s)
    AP000843, BC143946, BX537377, DA247864, DC332150, EU562298
    UniProtKB/Swiss-Prot
    Q14982
    UniProtKB/TrEMBL
    B2CZX3
    Conserved Domains (3) summary
    smart00409
    Location:232
    IG; Immunoglobulin
    smart00410
    Location:134212
    IG_like; Immunoglobulin like
    pfam13927
    Location:35106
    Ig_3; Immunoglobulin domain
  4. NM_001319105.1NP_001306034.1  opioid-binding protein/cell adhesion molecule isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream translation start site, and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The encoded isoform (e) is shorter and lacks a predicted signal peptide compared to isoform c.
    Source sequence(s)
    AK316491, AP000843, BC143946, DA247864
    Consensus CDS
    CCDS81649.1
    UniProtKB/Swiss-Prot
    Q14982
    Related
    ENSP00000363910.4, ENST00000374778.4
    Conserved Domains (3) summary
    smart00409
    Location:193271
    IG; Immunoglobulin
    pfam13927
    Location:94165
    Ig_3; Immunoglobulin domain
    cl11960
    Location:391
    Ig; Immunoglobulin domain
  5. NM_001319106.1NP_001306035.1  opioid-binding protein/cell adhesion molecule isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The encoded isoform (f) may undergo proteolytic processing similar to isoform a.
    Source sequence(s)
    AK314077, AP000843, BC143946, BX537377, DA247864
    UniProtKB/Swiss-Prot
    Q14982
    UniProtKB/TrEMBL
    B7ZLQ0
    Conserved Domains (3) summary
    smart00409
    Location:233311
    IG; Immunoglobulin
    pfam13927
    Location:135205
    Ig_3; Immunoglobulin domain
    cl11960
    Location:44132
    Ig; Immunoglobulin domain
  6. NM_002545.4NP_002536.1  opioid-binding protein/cell adhesion molecule isoform a preproprotein

    See identical proteins and their annotated locations for NP_002536.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The encoded isoform (a) is shorter than isoform c.
    Source sequence(s)
    AK314077, AP000843, BC143946, BX537377, DA247864, L34774
    Consensus CDS
    CCDS8492.1
    UniProtKB/Swiss-Prot
    Q14982
    UniProtKB/TrEMBL
    A8K0Y0
    Related
    ENSP00000330862.7, ENST00000331898.11
    Conserved Domains (3) summary
    smart00409
    Location:234312
    IG; Immunoglobulin
    pfam13927
    Location:135206
    Ig_3; Immunoglobulin domain
    cl11960
    Location:44132
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    132403361..133532612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542856.3XP_011541158.1  opioid-binding protein/cell adhesion molecule isoform X2

    See identical proteins and their annotated locations for XP_011541158.1

    UniProtKB/Swiss-Prot
    Q14982
    Conserved Domains (3) summary
    smart00409
    Location:193271
    IG; Immunoglobulin
    pfam13927
    Location:94165
    Ig_3; Immunoglobulin domain
    cl11960
    Location:391
    Ig; Immunoglobulin domain
  2. XM_006718846.3XP_006718909.1  opioid-binding protein/cell adhesion molecule isoform X1

    See identical proteins and their annotated locations for XP_006718909.1

    Conserved Domains (4) summary
    smart00408
    Location:142198
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:226304
    IG_like; Immunoglobulin like
    pfam00047
    Location:222303
    ig; Immunoglobulin domain
    cl11960
    Location:37125
    Ig; Immunoglobulin domain
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