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SLC11A2 solute carrier family 11 member 2 [ Homo sapiens (human) ]

Gene ID: 4891, updated on 12-Sep-2024

Summary

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Official Symbol
SLC11A2provided by HGNC
Official Full Name
solute carrier family 11 member 2provided by HGNC
Primary source
HGNC:HGNC:10908
See related
Ensembl:ENSG00000110911 MIM:600523; AllianceGenome:HGNC:10908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCT1; DMT1; AHMIO1; NRAMP2
Summary
This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
Expression
Ubiquitous expression in duodenum (RPKM 12.8), thyroid (RPKM 12.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
12q13.12
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (50952263..51028886, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (50915621..50992224, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51373190..51422669, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51251231-51251732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51251733-51252232 Neighboring gene CRISPRi-validated cis-regulatory element chr12.1615 Neighboring gene MPRA-validated peak1732 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6365 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:51319135-51319678 Neighboring gene Sharpr-MPRA regulatory region 4642 Neighboring gene thiol methyltransferase 1A Neighboring gene HIG1 hypoxia inducible domain family member 1C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51346409-51346909 Neighboring gene MPRA-validated peak1733 silencer Neighboring gene RNA, U7 small nuclear 39 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51419127-51419740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51419741-51420352 Neighboring gene RNA, U6 small nuclear 87, pseudogene Neighboring gene RNA, U6 small nuclear 1273, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51441816-51442354 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51442355-51442893 Neighboring gene LETM1 domain containing 1 Neighboring gene cysteine and serine rich nuclear protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SLC11A2: a promising biomarker and therapeutic target in ovarian cancer. Tian L, et al. Sci Rep, 2023 Jan 20. PMID 36670142, Free PMC Article
  2. Genotypic Effect of IVS4+44C>A and c.2044T>C DMT1 Gene Mutations on Pathophysiology of Iron-Deficiency Anemia. Pandey S, et al. Indian J Pediatr, 2022 Sep. PMID 35857262
  3. DOES SLC11A2 GENE MUTATION ASSOCIATE WITH IRON-REFRACTORY IRON-DEFICIENCY ANEMIA AFTER BARIATRIC SURGERY? Piatto VB, et al. Arq Bras Cir Dig, 2022. PMID 35730874, Free PMC Article
  4. Evaluation of divalent metal transporter 1 (DMT1) (rs224589) polymorphism on blood lead levels of occupationally exposed individuals. Mani MS, et al. Toxicol Lett, 2021 Dec 15. PMID 34626817
  5. Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds. Manatschal C, et al. Elife, 2019 Dec 5. PMID 31804182, Free PMC Article

See all (134) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ischemic Neuroprotection by Insulin with Down-Regulation of Divalent Metal Transporter 1 (DMT1) Expression and Ferrous Iron-Dependent Cell Death.
    Title: Ischemic Neuroprotection by Insulin with Down-Regulation of Divalent Metal Transporter 1 (DMT1) Expression and Ferrous Iron-Dependent Cell Death.
  2. DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth.
    Title: DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth.
  3. DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis.
    Title: DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis.
  4. SLC11A2: a promising biomarker and therapeutic target in ovarian cancer.
    Title: SLC11A2: a promising biomarker and therapeutic target in ovarian cancer.
  5. Genotypic Effect of IVS4+44C>A and c.2044T>C DMT1 Gene Mutations on Pathophysiology of Iron-Deficiency Anemia.
    Title: Genotypic Effect of IVS4+44C>A and c.2044T>C DMT1 Gene Mutations on Pathophysiology of Iron-Deficiency Anemia.
  6. Regulation of Iron-Ion Transporter SLC11A2 by Three Identical miRNAs.
    Title: Regulation of Iron-Ion Transporter SLC11A2 by Three Identical miRNAs.
  7. The Associations between Metalloestrogens, GSTP1, and SLC11A2 Polymorphism and the Risk of Endometrial Cancer.
    Title: The Associations between Metalloestrogens, GSTP1, and SLC11A2 Polymorphism and the Risk of Endometrial Cancer.
  8. DOES SLC11A2 GENE MUTATION ASSOCIATE WITH IRON-REFRACTORY IRON-DEFICIENCY ANEMIA AFTER BARIATRIC SURGERY?
    Title: DOES SLC11A2 GENE MUTATION ASSOCIATE WITH IRON-REFRACTORY IRON-DEFICIENCY ANEMIA AFTER BARIATRIC SURGERY?
  9. Evaluation of divalent metal transporter 1 (DMT1) (rs224589) polymorphism on blood lead levels of occupationally exposed individuals.
    Title: Evaluation of divalent metal transporter 1 (DMT1) (rs224589) polymorphism on blood lead levels of occupationally exposed individuals.
  10. Mutation analysis of seven SLC family transporters for early-onset Parkinson's disease in Chinese population.
    Title: Mutation analysis of seven SLC family transporters for early-onset Parkinson's disease in Chinese population.
Submit: New GeneRIF Correction See all GeneRIFs (93)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Microcytic anemia with liver iron overload
MedGen: C3806153 OMIM: 206100 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 and the viral protein Tat modulate the expression of solute carrier family 11, member 2 (SLC11A2; proton-coupled divalent metal ion transporter) in immature dendritic PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37416

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadmium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadmium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cadmium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadmium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cobalt ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables copper ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferrous iron transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrous iron transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferrous iron transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ferrous iron transmembrane transporter activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables iron ion transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables lead ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lead ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables manganese ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nickel cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables solute:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transition metal ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cadmium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cobalt ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in copper ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in copper ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in erythrocyte development IEA
Inferred from Electronic Annotation
more info
  
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular iron ion homeostasis TAS
Traceable Author Statement
more info
  
involved_in iron import into cell NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in iron ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in iron ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lead ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in learning or memory IEA
Inferred from Electronic Annotation
more info
  
involved_in manganese ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in manganese ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in manganese ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in multicellular organismal-level iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nickel cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to iron ion IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basal part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane HDA PubMed 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of paraferritin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
natural resistance-associated macrophage protein 2
Names
DMT-1
NRAMP 2
divalent cation transporter 1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021139.1 RefSeqGene

    Range
    5034..53492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1160

mRNA and Protein(s)

  1. NM_000617.3 → NP_000608.1  natural resistance-associated macrophage protein 2 isoform 3

    See identical proteins and their annotated locations for NP_000608.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus compared to isoform 1. Variants 4, 5 and 6 encode isoform 3.
    Source sequence(s)
    AB004857, BC100014, DA957633
    Consensus CDS
    CCDS8805.1
    UniProtKB/TrEMBL
    A0A2R8YD71
    Related
    ENSP00000262052.5, ENST00000262052.9
    Conserved Domains (2) summary
    TIGR01197
    Location:68 → 467
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    pfam01566
    Location:126 → 474
    Nramp; Natural resistance-associated macrophage protein

  2. NM_001174125.2 → NP_001167596.1  natural resistance-associated macrophage protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001167596.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC087884, AJ493662, BC002592
    Consensus CDS
    CCDS53793.1
    UniProtKB/TrEMBL
    A0A2R8YD71
    Related
    ENSP00000378364.3, ENST00000394904.9
    Conserved Domains (1) summary
    TIGR01197
    Location:97 → 496
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

  3. NM_001174126.2 → NP_001167597.1  natural resistance-associated macrophage protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001167597.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and in the 3' UTR and coding region compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Isoform 2 lacks the iron responsive element (IRE) found in isoform 1. Both variants 2 and 3 encode isoform 2.
    Source sequence(s)
    AC087884, AF064484, DB350334
    Consensus CDS
    CCDS53792.1
    UniProtKB/Swiss-Prot
    B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35
    UniProtKB/TrEMBL
    A0A0X8GKR4, A0A2R8YD71
    Related
    ENSP00000494107.1, ENST00000644495.1
    Conserved Domains (1) summary
    TIGR01197
    Location:68 → 467
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

  4. NM_001174127.2 → NP_001167598.1  natural resistance-associated macrophage protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001167598.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and in the 3' UTR and coding region compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Isoform 2 lacks the iron responsive element (IRE) found in isoform 1. Both variants 2 and 3 encode isoform 2.
    Source sequence(s)
    AC087884
    Consensus CDS
    CCDS53792.1
    UniProtKB/Swiss-Prot
    B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35
    UniProtKB/TrEMBL
    A0A0X8GKR4, A0A2R8YD71
    Related
    ENSP00000446769.1, ENST00000547198.5
    Conserved Domains (1) summary
    TIGR01197
    Location:68 → 467
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

  5. NM_001174128.2 → NP_001167599.1  natural resistance-associated macrophage protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001167599.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus compared to isoform 1. Variants 4, 5 and 6 encode isoform 3.
    Source sequence(s)
    AC087884, AF046997
    Consensus CDS
    CCDS8805.1
    UniProtKB/TrEMBL
    A0A2R8YD71
    Conserved Domains (2) summary
    TIGR01197
    Location:68 → 467
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    pfam01566
    Location:126 → 474
    Nramp; Natural resistance-associated macrophage protein

  6. NM_001174129.2 → NP_001167600.1  natural resistance-associated macrophage protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001167600.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus compared to isoform 1. Variants 4, 5 and 6 encode isoform 3.
    Source sequence(s)
    AC087884
    Consensus CDS
    CCDS8805.1
    UniProtKB/TrEMBL
    A0A2R8YD71
    Related
    ENSP00000444542.2, ENST00000541174.6
    Conserved Domains (2) summary
    TIGR01197
    Location:68 → 467
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    pfam01566
    Location:126 → 474
    Nramp; Natural resistance-associated macrophage protein

  7. NM_001174130.2 → NP_001167601.1  natural resistance-associated macrophage protein 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC087884, AK316507, DC324894
    Consensus CDS
    CCDS53791.1
    UniProtKB/TrEMBL
    A0A2R8YD71
    Related
    ENSP00000442810.2, ENST00000545993.7
    Conserved Domains (2) summary
    TIGR01197
    Location:64 → 463
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    pfam01566
    Location:122 → 470
    Nramp; Natural resistance-associated macrophage protein

  8. NM_001379446.1 → NP_001366375.1  natural resistance-associated macrophage protein 2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC087884
    Consensus CDS
    CCDS91695.1
    UniProtKB/TrEMBL
    A0A2R8YD71
    Related
    ENSP00000449200.2, ENST00000547688.7
    Conserved Domains (1) summary
    TIGR01197
    Location:97 → 496
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

  9. NM_001379447.2 → NP_001366376.1  natural resistance-associated macrophage protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC087884
    Consensus CDS
    CCDS53792.1
    UniProtKB/Swiss-Prot
    B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35
    UniProtKB/TrEMBL
    A0A0X8GKR4, A0A2R8YD71
    Conserved Domains (1) summary
    TIGR01197
    Location:68 → 467
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

  10. NM_001379448.1 → NP_001366377.1  natural resistance-associated macrophage protein 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC087884
    UniProtKB/TrEMBL
    A0A2R8YD71
    Conserved Domains (1) summary
    TIGR01197
    Location:64 → 463
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

  11. NM_001379455.1 → NP_001366384.1  natural resistance-associated macrophage protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC087884
    Consensus CDS
    CCDS53793.1
    UniProtKB/TrEMBL
    A0A2R8YD71
    Conserved Domains (1) summary
    TIGR01197
    Location:97 → 496
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

  12. NM_001414744.1 → NP_001401673.1  natural resistance-associated macrophage protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC087884
    UniProtKB/TrEMBL
    A0A2R8YD71

  13. NM_001414745.1 → NP_001401674.1  natural resistance-associated macrophage protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC087884
    UniProtKB/TrEMBL
    A0A2R8YD71

  14. NM_001414746.1 → NP_001401675.1  natural resistance-associated macrophage protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC087884
    UniProtKB/TrEMBL
    A0A2R8YD71
    Related
    ENSP00000493633.1, ENST00000643884.1

  15. NM_001414747.1 → NP_001401676.1  natural resistance-associated macrophage protein 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC087884
    UniProtKB/TrEMBL
    B7Z9M2

  16. NM_001414748.1 → NP_001401677.1  natural resistance-associated macrophage protein 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC087884
    UniProtKB/TrEMBL
    B7Z9M2

  17. NM_001414749.1 → NP_001401678.1  natural resistance-associated macrophage protein 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC087884
    UniProtKB/TrEMBL
    B7Z9M2, F8W1P7
    Related
    ENSP00000446914.1, ENST00000546743.5

  18. NM_001414750.1 → NP_001401679.1  natural resistance-associated macrophage protein 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC087884
    UniProtKB/TrEMBL
    B7Z9M2, F8W1P7

RNA

  1. NR_033421.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains an alternate 5' exon and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC087884, AK315987, CK000292

  2. NR_033422.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) contains an alternate 5' exon and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC087884, CD365137

  3. NR_166668.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC087884

  4. NR_166669.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC087884

  5. NR_166670.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC087884

  6. NR_183175.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC087884

  7. NR_183176.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC087884
    Related
    ENST00000642227.1

  8. NR_183177.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC087884

  9. NR_183178.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC087884

  10. NR_183179.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC087884

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    50952263..51028886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428887.1 → XP_047284843.1  natural resistance-associated macrophage protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A2R8YD71

  2. XM_011538405.4 → XP_011536707.1  natural resistance-associated macrophage protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011536707.1

    UniProtKB/Swiss-Prot
    B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35
    UniProtKB/TrEMBL
    A0A0X8GKR4, A0A2R8YD71
    Conserved Domains (1) summary
    TIGR01197
    Location:68 → 467
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

  3. XM_011538404.4 → XP_011536706.1  natural resistance-associated macrophage protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011536706.1

    UniProtKB/Swiss-Prot
    B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35
    UniProtKB/TrEMBL
    A0A0X8GKR4, A0A2R8YD71
    Conserved Domains (1) summary
    TIGR01197
    Location:68 → 467
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

RNA

  1. XR_001748720.2 RNA Sequence

  2. XR_007063077.1 RNA Sequence

  3. XR_007063078.1 RNA Sequence

  4. XR_944555.2 RNA Sequence

  5. XR_429104.2 RNA Sequence

  6. XR_007063079.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    50915621..50992224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372124.1 → XP_054228099.1  natural resistance-associated macrophage protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A2R8YD71

  2. XM_054372125.1 → XP_054228100.1  natural resistance-associated macrophage protein 2 isoform X2

    UniProtKB/Swiss-Prot
    B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35
    UniProtKB/TrEMBL
    A0A0X8GKR4, A0A2R8YD71

  3. XM_054372126.1 → XP_054228101.1  natural resistance-associated macrophage protein 2 isoform X2

    UniProtKB/Swiss-Prot
    B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35
    UniProtKB/TrEMBL
    A0A0X8GKR4, A0A2R8YD71

RNA

  1. XR_008488592.1 RNA Sequence

  2. XR_008488591.1 RNA Sequence

  3. XR_008488590.1 RNA Sequence

  4. XR_008488593.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49281.2 GenPept UniProtKB/Swiss-Prot:P49281

Gene LinkOut

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