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NPPC natriuretic peptide C [ Homo sapiens (human) ]

Gene ID: 4880, updated on 10-Dec-2024

Summary

Official Symbol
NPPCprovided by HGNC
Official Full Name
natriuretic peptide Cprovided by HGNC
Primary source
HGNC:HGNC:7941
See related
Ensembl:ENSG00000163273 MIM:600296; AllianceGenome:HGNC:7941
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNP; CNP2
Summary
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]
Annotation information
Note: CNP (Gene ID: 1267) and NPPC (Gene ID: 4880) share the CNP symbol/alias in common. CNP is a widely used alternative name for C-type natriuretic peptide (NPPC), which can be confused with the official symbol for 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP). [06 Jul 2018]
Expression
Biased expression in prostate (RPKM 1.1), esophagus (RPKM 0.4) and 9 other tissues See more
Orthologs
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Genomic context

See NPPC in Genome Data Viewer
Location:
2q37.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (231921809..231926396, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (232408446..232413033, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (232786519..232791106, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12450 Neighboring gene guanidinoacetate N-methyltransferase pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:232769840-232770458 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:232770459-232771076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:232791796-232792450 Neighboring gene microRNA 1471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17318 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12454 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:232854631-232855252 Neighboring gene DIS3 like 3'-5' exoribonuclease 2 Neighboring gene MPRA-validated peak4085 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr2:232986245-232986439 Neighboring gene Sharpr-MPRA regulatory region 7061 Neighboring gene microRNA 562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233096173-233096674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12456 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12457 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:233141549-233142064 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:233156819-233157542 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:233157543-233158264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233194285-233195258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:233197669-233198468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:233198469-233199268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233201669-233202468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233207551-233208060 Neighboring gene NRBF2 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in blood vessel diameter maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in c-di-GMP signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of cGMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glycoprotein IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cumulus cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in gastric emptying IEA
Inferred from Electronic Annotation
more info
 
involved_in growth plate cartilage chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in growth plate cartilage chondrocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic cell cycle process involved in oocyte maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organismal locomotion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of collagen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of meiotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of oocyte maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in protein folding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in receptor guanylyl cyclase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to axon injury IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ischemia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxygen-glucose deprivation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
C-type natriuretic peptide
Names
natriuretic peptide precursor type C

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024409.4NP_077720.1  C-type natriuretic peptide preproprotein

    See identical proteins and their annotated locations for NP_077720.1

    Status: REVIEWED

    Source sequence(s)
    AC013435, D20847, DR003533, JF420840
    Consensus CDS
    CCDS2489.1
    UniProtKB/Swiss-Prot
    P23582, Q4ZG41
    Related
    ENSP00000387159.1, ENST00000409852.2
    Conserved Domains (1) summary
    pfam00212
    Location:96126
    ANP; Atrial natriuretic peptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    231921809..231926396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511245.4XP_011509547.1  C-type natriuretic peptide isoform X1

    See identical proteins and their annotated locations for XP_011509547.1

    UniProtKB/Swiss-Prot
    P23582, Q4ZG41
    Conserved Domains (1) summary
    pfam00212
    Location:96126
    ANP; Atrial natriuretic peptide

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    232408446..232413033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342295.1XP_054198270.1  C-type natriuretic peptide isoform X1

    UniProtKB/Swiss-Prot
    P23582, Q4ZG41