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NME1 NME/NM23 nucleoside diphosphate kinase 1 [ Homo sapiens (human) ]

Gene ID: 4830, updated on 7-Apr-2019

Summary

Official Symbol
NME1provided by HGNC
Official Full Name
NME/NM23 nucleoside diphosphate kinase 1provided by HGNC
Primary source
HGNC:HGNC:7849
See related
Ensembl:ENSG00000239672 MIM:156490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NB; AWD; NBS; GAAD; NDKA; NM23; NDPKA; NDPK-A; NM23-H1
Summary
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 37.1), brain (RPKM 32.2) and 25 other tissues See more
Orthologs

Genomic context

See NME1 in Genome Data Viewer
Location:
17q21.33
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (51153559..51162089)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (49230920..49239450)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371825 Neighboring gene sperm associated antigen 9 Neighboring gene NME1-NME2 readthrough Neighboring gene NME/NM23 nucleoside diphosphate kinase 2 Neighboring gene mbt domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
SiRNA-mediated knockdown of one of the components of the SET complex, NM23-H1, inhibits HIV-1 infection with significantly reduced levels of integrated HIV-1 DNA and viral production in HeLa-CD4 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
reverse transcriptase gag-pol HIV-1 RT forms a complex with NDPKA in vitro PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
deoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
intermediate filament binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside diphosphate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosomal small subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
GTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
UTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
cellular response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
lactation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myeloid leukocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing small molecule interconversion TAS
Traceable Author Statement
more info
 
nucleoside diphosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
response to amine IEA
Inferred from Electronic Annotation
more info
 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to testosterone IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nucleoside diphosphate kinase A
Names
NDP kinase A
epididymis secretory sperm binding protein
granzyme A-activated DNase
metastasis inhibition factor nm23
non-metastatic cells 1, protein (NM23A) expressed in
tumor metastatic process-associated protein
NP_000260.1
NP_937818.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021169.1 RefSeqGene

    Range
    5001..13531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000269.2NP_000260.1  nucleoside diphosphate kinase A isoform b

    See identical proteins and their annotated locations for NP_000260.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AF487339, BE727815, BF965472, BG715560, BI666785, BM479520, BU600979
    Consensus CDS
    CCDS11579.1
    UniProtKB/Swiss-Prot
    P15531
    Related
    ENSP00000376892.3, ENST00000393196.7
    Conserved Domains (1) summary
    PTZ00093
    Location:5151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
  2. NM_198175.1NP_937818.1  nucleoside diphosphate kinase A isoform a

    See identical proteins and their annotated locations for NP_937818.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF487339, AL360191, BE727815, BF965472, BG531372, BG715560, BG757842, BI666785, BM479520
    Consensus CDS
    CCDS11578.1
    UniProtKB/Swiss-Prot
    P15531
    Related
    ENSP00000337060.3, ENST00000336097.7
    Conserved Domains (2) summary
    PTZ00093
    Location:30176
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
    pfam00334
    Location:30164
    NDK; Nucleoside diphosphate kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    51153559..51162089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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