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KMT2A lysine methyltransferase 2A [ Homo sapiens (human) ]

Gene ID: 4297, updated on 5-May-2024

Summary

Official Symbol
KMT2Aprovided by HGNC
Official Full Name
lysine methyltransferase 2Aprovided by HGNC
Primary source
HGNC:HGNC:7132
See related
Ensembl:ENSG00000118058 MIM:159555; AllianceGenome:HGNC:7132
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRX; MLL; ALL1; GAS7; HTRX; MLL1; TRX1; ALL-1; CXXC7; HTRX1; MLL1A; WDSTS
Summary
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
Expression
Ubiquitous expression in ovary (RPKM 12.8), lymph node (RPKM 6.8) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See KMT2A in Genome Data Viewer
Location:
11q23.3
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (118436492..118526832)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (118455794..118546121)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118307207..118397547)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5590 Neighboring gene ubiquitination factor E4A Neighboring gene uncharacterized LOC100131626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5591 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:118272182-118273045 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118273504-118274094 Neighboring gene ATP synthase membrane subunit g Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr11:118306179-118307176 and GRCh37_chr11:118307177-118308175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118308176-118309173 Neighboring gene Sharpr-MPRA regulatory region 11577 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:118358704-118358932 Neighboring gene TTC36 and KMT2A antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 12917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3947 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene transmembrane protein 25 Neighboring gene intraflagellar transport 46

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Wiedemann-Steiner syndrome
MedGen: C1854630 OMIM: 605130 GeneReviews: Wiedemann-Steiner Syndrome
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2018-05-23)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2018-05-23)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol The IN catalytic core domain has a higher binding affinity (Kd) for PSIP1 (LEDGF/p75) than the physiological binding partner, KMT2A (MML1) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ11783

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K4 methyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
enables histone H3K4 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H3K4 methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3K4 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone H3K4 methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables histone H3K4 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K4 trimethyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables minor groove of adenine-thymine-rich DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-cysteine methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables unmethylated CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in T-helper 2 cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in definitive hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic hemopoiesis TAS
Traceable Author Statement
more info
PubMed 
involved_in exploration behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane depolarization IEA
Inferred from Electronic Annotation
more info
 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA methylation-dependent heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of short-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to potassium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in spleen development IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription initiation-coupled chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription initiation-coupled chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of MLL1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of histone methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of histone methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
histone-lysine N-methyltransferase 2A
Names
Acute lymphocytic 1
CXXC-type zinc finger protein 7
lysine (K)-specific methyltransferase 2A
lysine N-methyltransferase 2A
mixed lineage leukemia 1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
trithorax-like protein
zinc finger protein HRX
NP_001184033.1
NP_001399526.1
NP_005924.2
XP_006718902.2
XP_011541131.1
XP_011541132.1
XP_011541135.1
XP_047282919.1
XP_047282920.1
XP_054224805.1
XP_054224806.1
XP_054224807.1
XP_054224808.1
XP_054224809.1
XP_054224810.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027813.1 RefSeqGene

    Range
    5001..95335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_613

mRNA and Protein(s)

  1. NM_001197104.2NP_001184033.1  histone-lysine N-methyltransferase 2A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.
    Source sequence(s)
    AI500057, AP000941, AP001267, BC065385, D14540, L04731
    Consensus CDS
    CCDS55791.1
    UniProtKB/TrEMBL
    A0A8I5KXR3
    Related
    ENSP00000436786.2, ENST00000534358.8
    Conserved Domains (9) summary
    cd05493
    Location:16501780
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:36723755
    FYRC; FY-rich domain, C-terminal region
    cd15588
    Location:14331479
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:14811530
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:15681627
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:18741986
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
    pfam02008
    Location:11471194
    zf-CXXC; CXXC zinc finger domain
    pfam05964
    Location:20272074
    FYRN; F/Y-rich N-terminus
    cd19170
    Location:38193972
    SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
  2. NM_001412597.1NP_001399526.1  histone-lysine N-methyltransferase 2A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AP000941, AP001267
    UniProtKB/TrEMBL
    A0AA34QVI8
    Related
    ENSP00000518343.1, ENST00000710560.1
  3. NM_005933.4NP_005924.2  histone-lysine N-methyltransferase 2A isoform 2 precursor

    See identical proteins and their annotated locations for NP_005924.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 3. This results in a shorter protein (isoform 2), compared to isoform 3.
    Source sequence(s)
    AB209508, AP000941, AP001267, BC065385, D14540
    Consensus CDS
    CCDS31686.1
    UniProtKB/Swiss-Prot
    E9PQG7, Q03164, Q13743, Q13744, Q14845, Q16364, Q59FF2, Q6UBD1, Q9HBJ3, Q9UD94, Q9UMA3
    UniProtKB/TrEMBL
    A0A8I5KXR3
    Related
    ENSP00000374157.5, ENST00000389506.10
    Conserved Domains (11) summary
    cd05493
    Location:16471777
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:36693752
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:38313951
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:39533969
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:38253969
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    pfam02008
    Location:11471194
    zf-CXXC; CXXC zinc finger domain
    cd15588
    Location:14331479
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:14811530
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:15681624
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:18711983
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
    pfam05964
    Location:20252071
    FYRN; F/Y-rich N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    118436492..118526832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542829.3XP_011541131.1  histone-lysine N-methyltransferase 2A isoform X1

    UniProtKB/TrEMBL
    A0A8I5KXR3, E9PR05
    Related
    ENSP00000432391.3, ENST00000531904.7
    Conserved Domains (11) summary
    cd05493
    Location:16831813
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:37053788
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:38673987
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:39894005
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:38614005
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    pfam02008
    Location:11801227
    zf-CXXC; CXXC zinc finger domain
    cd15588
    Location:14661512
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:15141563
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:16011660
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:19072019
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
    pfam05964
    Location:20612107
    FYRN; F/Y-rich N-terminus
  2. XM_011542830.3XP_011541132.1  histone-lysine N-methyltransferase 2A isoform X2

    UniProtKB/TrEMBL
    A0A8I5KXR3
    Conserved Domains (11) summary
    cd05493
    Location:16821812
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:37043787
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:38663986
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:39884004
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:38604004
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    pfam02008
    Location:11801227
    zf-CXXC; CXXC zinc finger domain
    cd15588
    Location:14661512
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:15141562
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:16001659
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:19062018
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
    pfam05964
    Location:20602106
    FYRN; F/Y-rich N-terminus
  3. XM_047426963.1XP_047282919.1  histone-lysine N-methyltransferase 2A isoform X3

  4. XM_011542833.3XP_011541135.1  histone-lysine N-methyltransferase 2A isoform X4

    Conserved Domains (11) summary
    cd05493
    Location:844974
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:28662949
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:30283148
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:31503166
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:30143166
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    pfam02008
    Location:341388
    zf-CXXC; CXXC zinc finger domain
    cd15588
    Location:627673
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:675724
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:762821
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:10681180
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
    pfam05964
    Location:12221268
    FYRN; F/Y-rich N-terminus
  5. XM_006718839.4XP_006718902.2  histone-lysine N-methyltransferase 2A isoform X5

    Conserved Domains (11) summary
    cd05493
    Location:811941
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:28332916
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:29953115
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:31173133
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:29813133
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    pfam02008
    Location:308355
    zf-CXXC; CXXC zinc finger domain
    cd15588
    Location:594640
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:642691
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:729788
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:10351147
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
    pfam05964
    Location:11891235
    FYRN; F/Y-rich N-terminus
  6. XM_047426964.1XP_047282920.1  histone-lysine N-methyltransferase 2A isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    118455794..118546121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368830.1XP_054224805.1  histone-lysine N-methyltransferase 2A isoform X1

    UniProtKB/TrEMBL
    E9PR05
  2. XM_054368831.1XP_054224806.1  histone-lysine N-methyltransferase 2A isoform X2

  3. XM_054368832.1XP_054224807.1  histone-lysine N-methyltransferase 2A isoform X3

  4. XM_054368833.1XP_054224808.1  histone-lysine N-methyltransferase 2A isoform X4

  5. XM_054368834.1XP_054224809.1  histone-lysine N-methyltransferase 2A isoform X5

  6. XM_054368835.1XP_054224810.1  histone-lysine N-methyltransferase 2A isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024891.2: Suppressed sequence

    Description
    NM_024891.2: This RefSeq was permanently suppressed because it is primarily intronic sequence.