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MGST1 microsomal glutathione S-transferase 1 [ Homo sapiens (human) ]

Gene ID: 4257, updated on 17-Jun-2019

Summary

Official Symbol
MGST1provided by HGNC
Official Full Name
microsomal glutathione S-transferase 1provided by HGNC
Primary source
HGNC:HGNC:7061
See related
Ensembl:ENSG00000008394 MIM:138330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MGST; GST12; MGST-I
Summary
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]
Expression
Biased expression in fat (RPKM 182.4), liver (RPKM 177.8) and 13 other tissues See more
Orthologs

Genomic context

See MGST1 in Genome Data Viewer
Location:
12p12.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (16347142..16377192)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (16500076..16530123)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene deoxyribose-phosphate aldolase Neighboring gene VISTA enhancer hs798 Neighboring gene uncharacterized LOC101928362 Neighboring gene solute carrier family 15 member 5 Neighboring gene uncharacterized LOC107984494 Neighboring gene SPT16 homolog, facilitates chromatin remodeling subunit pseudogene 1 Neighboring gene VISTA enhancer hs607

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

Pathways from BioSystems

  • Aflatoxin activation and detoxification, organism-specific biosystem (from REACTOME)
    Aflatoxin activation and detoxification, organism-specific biosystemAflatoxins are among the principal mycotoxins produced as secondary metabolites by the molds Aspergillus flavus and Aspergillus parasiticus that contaminate economically important food and feed crops...
  • Aryl Hydrocarbon Receptor Pathway, organism-specific biosystem (from WikiPathways)
    Aryl Hydrocarbon Receptor Pathway, organism-specific biosystemThe aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic m...
  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Chemical carcinogenesis, organism-specific biosystem (from KEGG)
    Chemical carcinogenesis, organism-specific biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
  • Chemical carcinogenesis, conserved biosystem (from KEGG)
    Chemical carcinogenesis, conserved biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
  • Drug metabolism - cytochrome P450, organism-specific biosystem (from KEGG)
    Drug metabolism - cytochrome P450, organism-specific biosystem
    Drug metabolism - cytochrome P450
  • Drug metabolism - cytochrome P450, conserved biosystem (from KEGG)
    Drug metabolism - cytochrome P450, conserved biosystem
    Drug metabolism - cytochrome P450
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Glutathione conjugation, organism-specific biosystem (from REACTOME)
    Glutathione conjugation, organism-specific biosystemGlutathione S-Transferases (GSTs; EC 2.5.1.18) are another major set of phase II conjugation enzymes. They can be found in the cytosol as well as being microsomal membrane-bound. Cytosolic GSTs are e...
  • Glutathione metabolism, organism-specific biosystem (from KEGG)
    Glutathione metabolism, organism-specific biosystem
    Glutathione metabolism
  • Glutathione metabolism, conserved biosystem (from KEGG)
    Glutathione metabolism, conserved biosystem
    Glutathione metabolism
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem (from KEGG)
    Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem
    Metabolism of xenobiotics by cytochrome P450
  • Metabolism of xenobiotics by cytochrome P450, conserved biosystem (from KEGG)
    Metabolism of xenobiotics by cytochrome P450, conserved biosystem
    Metabolism of xenobiotics by cytochrome P450
  • Metapathway biotransformation, organism-specific biosystem (from WikiPathways)
    Metapathway biotransformation, organism-specific biosystem
    Metapathway biotransformation
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Oxidative Stress, organism-specific biosystem (from WikiPathways)
    Oxidative Stress, organism-specific biosystemOxidative stress represents an imbalance between the production and manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to rep...
  • Phase II conjugation, organism-specific biosystem (from REACTOME)
    Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
  • Platinum drug resistance, organism-specific biosystem (from KEGG)
    Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
  • Platinum drug resistance, conserved biosystem (from KEGG)
    Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
  • glutathione-mediated detoxification, organism-specific biosystem (from BIOCYC)
    glutathione-mediated detoxification, organism-specific biosystemPlease note: This is a general detoxification pathway, where the first step can be catalyzed by many different enzymes, collectively known as glutathione transferases, or GSTs. In the first reaction,...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14525

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione binding IEA
Inferred from Electronic Annotation
more info
 
glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT prostaglandin-E synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Leydig cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipid hydroperoxide IDA
Inferred from Direct Assay
more info
PubMed 
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
NOT prostaglandin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homotrimerization ISS
Inferred from Sequence or Structural Similarity
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
azurophil granule membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
microsomal glutathione S-transferase 1
Names
glutathione S-transferase 12
microsomal GST-1
microsomal GST-I
NP_001247440.1
NP_001247441.1
NP_001254527.1
NP_064696.1
NP_665707.1
NP_665734.1
NP_665735.1
XP_006719142.1
XP_011518975.1
XP_011518976.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001260511.1NP_001247440.1  microsomal glutathione S-transferase 1 isoform a

    See identical proteins and their annotated locations for NP_001247440.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AW166965, BC005923, BG569388, BG617746
    Consensus CDS
    CCDS8677.1
    UniProtKB/Swiss-Prot
    P10620
    UniProtKB/TrEMBL
    A0A024RAX2
    Conserved Domains (1) summary
    pfam01124
    Location:16149
    MAPEG; MAPEG family
  2. NM_001260512.1NP_001247441.1  microsomal glutathione S-transferase 1 isoform b

    See identical proteins and their annotated locations for NP_001247441.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and contains an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC007528, AW166965, BC005923, BE568125, BG617746
    UniProtKB/Swiss-Prot
    P10620
    Conserved Domains (1) summary
    COG1232
    Location:884
    HemY; Protoporphyrinogen oxidase [Coenzyme transport and metabolism]
  3. NM_001267598.2NP_001254527.1  microsomal glutathione S-transferase 1 isoform c

    See identical proteins and their annotated locations for NP_001254527.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and has an alternate exon in place of the last exon compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC007528, BC056863, BG617746
    Consensus CDS
    CCDS58209.1
    UniProtKB/Swiss-Prot
    P10620
    Related
    ENSP00000438308.1, ENST00000535309.5
  4. NM_020300.5NP_064696.1  microsomal glutathione S-transferase 1 isoform a

    See identical proteins and their annotated locations for NP_064696.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also called 1b) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AW166965, BC005923, BG617746
    Consensus CDS
    CCDS8677.1
    UniProtKB/Swiss-Prot
    P10620
    UniProtKB/TrEMBL
    A0A024RAX2
    Related
    ENSP00000379513.3, ENST00000396210.8
    Conserved Domains (1) summary
    pfam01124
    Location:16149
    MAPEG; MAPEG family
  5. NM_145764.2NP_665707.1  microsomal glutathione S-transferase 1 isoform a

    See identical proteins and their annotated locations for NP_665707.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also called 1d) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AW166965, BC005923, J03746
    Consensus CDS
    CCDS8677.1
    UniProtKB/Swiss-Prot
    P10620
    UniProtKB/TrEMBL
    A0A024RAX2
    Related
    ENSP00000379510.1, ENST00000396207.1
    Conserved Domains (1) summary
    pfam01124
    Location:16149
    MAPEG; MAPEG family
  6. NM_145791.2NP_665734.1  microsomal glutathione S-transferase 1 isoform a

    See identical proteins and their annotated locations for NP_665734.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also called 1c) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AA314967, AV655242, AW166965, BC005923
    Consensus CDS
    CCDS8677.1
    UniProtKB/Swiss-Prot
    P10620
    UniProtKB/TrEMBL
    A0A024RAX2
    Related
    ENSP00000379512.1, ENST00000396209.5
    Conserved Domains (1) summary
    pfam01124
    Location:16149
    MAPEG; MAPEG family
  7. NM_145792.2NP_665735.1  microsomal glutathione S-transferase 1 isoform a

    See identical proteins and their annotated locations for NP_665735.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also called 1a) encodes isoform a. Variants 1, 2, 3, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AW166965, BC005923, R86750
    Consensus CDS
    CCDS8677.1
    UniProtKB/Swiss-Prot
    P10620
    UniProtKB/TrEMBL
    A0A024RAX2
    Related
    ENSP00000010404.2, ENST00000010404.6
    Conserved Domains (1) summary
    pfam01124
    Location:16149
    MAPEG; MAPEG family

RNA

  1. NR_048545.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the first exon and lacks an internal exon compared to variant 1. This variant is represented as noncoding because the predicted protein is shorter than 60 aa, and there is no support for the existence of this protein.
    Source sequence(s)
    AW166965, BC005923, BG778603
  2. NR_048547.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the first exon and lacks an internal exon compared to variant 1. This variant is represented as noncoding because the predicted protein is shorter than 60 aa, and there is no support for the existence of this protein.
    Source sequence(s)
    AA314967, AW166965, BC005923

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    16347142..16377192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520674.2XP_011518976.1  microsomal glutathione S-transferase 1 isoform X2

    Conserved Domains (1) summary
    pfam01124
    Location:1676
    MAPEG; MAPEG family
  2. XM_006719079.1XP_006719142.1  microsomal glutathione S-transferase 1 isoform X3

    See identical proteins and their annotated locations for XP_006719142.1

    Conserved Domains (1) summary
    pfam01124
    Location:1676
    MAPEG; MAPEG family
  3. XM_011520673.1XP_011518975.1  microsomal glutathione S-transferase 1 isoform X1

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