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SCGB2A1 secretoglobin family 2A member 1 [ Homo sapiens (human) ]

Gene ID: 4246, updated on 15-Apr-2019

Summary

Official Symbol
SCGB2A1provided by HGNC
Official Full Name
secretoglobin family 2A member 1provided by HGNC
Primary source
HGNC:HGNC:7051
See related
Ensembl:ENSG00000124939 MIM:604398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPHC; LPNC; MGB2; UGB3
Expression
Biased expression in endometrium (RPKM 28.0), stomach (RPKM 15.9) and 4 other tissues See more
Orthologs

Genomic context

See SCGB2A1 in Genome Data Viewer
Location:
11q12.3
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (62208668..62213939)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61976140..61981411)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 8 Neighboring gene secretoglobin family 1D member 1 Neighboring gene secretoglobin family 1D member 2 Neighboring gene secretoglobin family 2A member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat upregulates the expression of many proteins, including Mammaglobin, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71973

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
androgen receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mammaglobin-B
Names
lacryglobin
lipophilin C
mammaglobin-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002407.3NP_002398.1  mammaglobin-B precursor

    See identical proteins and their annotated locations for NP_002398.1

    Status: VALIDATED

    Source sequence(s)
    AF071219, AJ224173, AP003306, BC062218
    Consensus CDS
    CCDS8016.1
    UniProtKB/Swiss-Prot
    O75556
    Related
    ENSP00000244930.4, ENST00000244930.6
    Conserved Domains (1) summary
    pfam01099
    Location:2290
    Uteroglobin; Uteroglobin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    62208668..62213939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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