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MAS1 MAS1 proto-oncogene, G protein-coupled receptor [ Homo sapiens (human) ]

Gene ID: 4142, updated on 15-Apr-2019

Summary

Official Symbol
MAS1provided by HGNC
Official Full Name
MAS1 proto-oncogene, G protein-coupled receptorprovided by HGNC
Primary source
HGNC:HGNC:6899
See related
Ensembl:ENSG00000130368 MIM:165180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAS; MGRA
Summary
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]
Orthologs

Genomic context

See MAS1 in Genome Data Viewer
Location:
6q25.3
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (159906942..159908076)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (160320218..160329339)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene PARN like, ribonuclease domain containing 1 Neighboring gene uncharacterized LOC105378087 Neighboring gene insulin like growth factor 2 receptor Neighboring gene antisense of IGF2R non-protein coding RNA

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119966

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
angiotensin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiotensin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
angiotensin type II receptor activity TAS
Traceable Author Statement
more info
PubMed 
peptide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of NF-kappaB-inducing kinase activity IEA
Inferred from Electronic Annotation
more info
 
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
angiotensin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
response to activity IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to gonadotropin IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proto-oncogene Mas
Names
MAS1 oncogene
Mas-related G protein-coupled receptor A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366704.1NP_001353633.1  proto-oncogene Mas

    Status: REVIEWED

    Source sequence(s)
    AL035691
    Conserved Domains (1) summary
    cd15110
    Location:33307
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_002377.3NP_002368.1  proto-oncogene Mas

    See identical proteins and their annotated locations for NP_002368.1

    Status: REVIEWED

    Source sequence(s)
    AL035691, DB475311
    Consensus CDS
    CCDS5272.1
    UniProtKB/Swiss-Prot
    P04201
    UniProtKB/TrEMBL
    W8W3P4
    Related
    ENSP00000252660.4, ENST00000252660.5
    Conserved Domains (1) summary
    cd15110
    Location:33307
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    159906942..159908076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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