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MAGEB2 MAGE family member B2 [ Homo sapiens (human) ]

Gene ID: 4113, updated on 15-Apr-2019

Summary

Official Symbol
MAGEB2provided by HGNC
Official Full Name
MAGE family member B2provided by HGNC
Primary source
HGNC:HGNC:6809
See related
Ensembl:ENSG00000099399 MIM:300098
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAM6; CT3.2; MAGE-XP-2
Summary
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 20.5) See more
Orthologs

Genomic context

See MAGEB2 in Genome Data Viewer
Location:
Xp21.2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (30215558..30220089)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (30233675..30238206)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAGE family member A10 pseudogene Neighboring gene uncharacterized LOC107985632 Neighboring gene MAGE family member B3 Neighboring gene MAGE family member B4 Neighboring gene MAGE family member B1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26438

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
melanoma-associated antigen B2
Names
DSS/AHC critical interval MAGE superfamily 6
MAGE XP-2 antigen
MAGE-B2 antigen
cancer/testis antigen 3.2
cancer/testis antigen family 3, member 2
melanoma antigen family B, 2
melanoma antigen family B2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013246.1 RefSeqGene

    Range
    5001..9532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002364.5NP_002355.2  melanoma-associated antigen B2

    See identical proteins and their annotated locations for NP_002355.2

    Status: REVIEWED

    Source sequence(s)
    AC005185, AK223081
    Consensus CDS
    CCDS14219.1
    UniProtKB/Swiss-Prot
    O15479
    UniProtKB/TrEMBL
    Q53G50
    Related
    ENSP00000368273.4, ENST00000378988.5
    Conserved Domains (2) summary
    pfam01454
    Location:139286
    MAGE; MAGE family
    pfam12440
    Location:593
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    30215558..30220089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545512.1XP_011543814.1  melanoma-associated antigen B2 isoform X1

    See identical proteins and their annotated locations for XP_011543814.1

    UniProtKB/Swiss-Prot
    O15479
    Conserved Domains (2) summary
    pfam01454
    Location:139286
    MAGE; MAGE family
    pfam12440
    Location:593
    MAGE_N; Melanoma associated antigen family N terminal
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