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MAG myelin associated glycoprotein [ Homo sapiens (human) ]

Gene ID: 4099, updated on 17-Jun-2019

Summary

Official Symbol
MAGprovided by HGNC
Official Full Name
myelin associated glycoproteinprovided by HGNC
Primary source
HGNC:HGNC:6783
See related
Ensembl:ENSG00000105695 MIM:159460
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GMA; S-MAG; SPG75; SIGLEC4A; SIGLEC-4A
Summary
The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010]
Expression
Biased expression in brain (RPKM 53.6) and ovary (RPKM 16.9) See more
Orthologs

Genomic context

See MAG in Genome Data Viewer
Location:
19q13.12
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35292086..35313807)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35782989..35804710)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene HNF4 motif-containing MPRA enhancer 344 Neighboring gene hepcidin antimicrobial peptide Neighboring gene CD22 molecule Neighboring gene microRNA 5196 Neighboring gene free fatty acid receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binds to myelin associated glycoprotein (MAG), an autoantigen in demyelinating neuropathy PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Axonal growth inhibition (RHOA activation), organism-specific biosystem (from REACTOME)
    Axonal growth inhibition (RHOA activation), organism-specific biosystemp75NTR can also form a receptor complex with the Nogo receptor (NgR). Such complexes mediates axonal outgrowth inhibitory signals of MDGIs (myelin-derived growth-inhibitors), such as Nogo66, myelin-a...
  • Basigin interactions, organism-specific biosystem (from REACTOME)
    Basigin interactions, organism-specific biosystemBasigin is a widely expressed transmembrane glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of epithelial cells. Basigin is involved in intercellular interaction...
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Glial Cell Differentiation, organism-specific biosystem (from WikiPathways)
    Glial Cell Differentiation, organism-specific biosystem
    Glial Cell Differentiation
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • MECP2 and Associated Rett Syndrome, organism-specific biosystem (from WikiPathways)
    MECP2 and Associated Rett Syndrome, organism-specific biosystemMecp2 is in many mammals an important regulator of neuronal function and development. It affects all cell types, especially neurons but also astrocytes, oligodendrocytes, and glial cells. Mecp2 plays...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
  • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
    p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...
  • p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
    p75(NTR)-mediated signaling, organism-specific biosystem
    p75(NTR)-mediated signaling
  • p75NTR regulates axonogenesis, organism-specific biosystem (from REACTOME)
    p75NTR regulates axonogenesis, organism-specific biosystemp75NTR modulates axonal growth by regulating the activity of small GTPases like RHOA and RHOB, that control the state of actin polymerization. The best studied is RHOA. In its active, GTP-bound form,...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CD22

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
ganglioside GT1b binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
sialic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
axon regeneration IEA
Inferred from Electronic Annotation
more info
 
cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell adhesion via plasma-membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
central nervous system myelination IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
negative regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of axonogenesis TAS
Traceable Author Statement
more info
 
negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myelination IEA
Inferred from Electronic Annotation
more info
 
transmission of nerve impulse IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Schmidt-Lanterman incisure IEA
Inferred from Electronic Annotation
more info
 
compact myelin IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
mesaxon IEA
Inferred from Electronic Annotation
more info
 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath adaxonal region IEA
Inferred from Electronic Annotation
more info
 
paranode region of axon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
myelin-associated glycoprotein
Names
sialic acid binding Ig-like lectin 4A
sialic acid-binding immunoglobulin-like lectin 4A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034078.1 RefSeqGene

    Range
    5001..26722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199216.1NP_001186145.1  myelin-associated glycoprotein isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK308976, BC093045, DC331168
    Consensus CDS
    CCDS56090.1
    UniProtKB/Swiss-Prot
    P20916
    Related
    ENSP00000440695.1, ENST00000537831.2
    Conserved Domains (5) summary
    cd05712
    Location:1114
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00408
    Location:314374
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:308384
    IG_like; Immunoglobulin like
    pfam07679
    Location:215297
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:116198
    Ig; Immunoglobulin domain
  2. NM_002361.4NP_002352.1  myelin-associated glycoprotein isoform a precursor

    See identical proteins and their annotated locations for NP_002352.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks exon 11 and has the stop codon in exon 12, as compared to variant 2. Isoform a is 44 aa longer and contains a different carboxy terminus when compared to isoform b.
    Source sequence(s)
    AK223562, BC093045
    Consensus CDS
    CCDS12455.1
    UniProtKB/Swiss-Prot
    P20916
    UniProtKB/TrEMBL
    Q53ES7
    Related
    ENSP00000376048.2, ENST00000392213.8
    Conserved Domains (4) summary
    cd05712
    Location:22139
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:333409
    IG_like; Immunoglobulin like
    pfam13927
    Location:239309
    Ig_3; Immunoglobulin domain
    cl11960
    Location:141223
    Ig; Immunoglobulin domain
  3. NM_080600.2NP_542167.1  myelin-associated glycoprotein isoform b precursor

    See identical proteins and their annotated locations for NP_542167.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is a full-length transcript with the stop codon contained in exon 11. It encodes an isoform (b) that is 44 aa shorter and contains a different carboxy terminus when compared to isoform a.
    Source sequence(s)
    BC093045, DC331168
    Consensus CDS
    CCDS12456.1
    UniProtKB/Swiss-Prot
    P20916
    Related
    ENSP00000355234.4, ENST00000361922.8
    Conserved Domains (5) summary
    cd05712
    Location:22139
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00408
    Location:339399
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:333409
    IG_like; Immunoglobulin like
    pfam07679
    Location:240322
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:141223
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35292086..35313807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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