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LBP lipopolysaccharide binding protein [ Homo sapiens (human) ]

Gene ID: 3929, updated on 17-Feb-2019

Summary

Official Symbol
LBPprovided by HGNC
Official Full Name
lipopolysaccharide binding proteinprovided by HGNC
Primary source
HGNC:HGNC:6517
See related
Ensembl:ENSG00000129988 MIM:151990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BPIFD2
Summary
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
Expression
Restricted expression toward liver (RPKM 139.3) See more
Orthologs

Genomic context

See LBP in Genome Data Viewer
Location:
20q11.23
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (38346411..38377011)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (36974814..37005653)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene KIAA1755 Neighboring gene uncharacterized LOC149684 Neighboring gene bactericidal permeability increasing protein Neighboring gene small nucleolar RNA, H/ACA box 71B Neighboring gene small nucleolar RNA host gene 17 Neighboring gene small nucleolar RNA, H/ACA box 71A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of chronic periodontitis in a general German population.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of lipopolysaccharide binding protein (LBP) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • IL6-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL6-mediated signaling events, organism-specific biosystem
    IL6-mediated signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
    NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • Regulation of TLR by endogenous ligand, organism-specific biosystem (from REACTOME)
    Regulation of TLR by endogenous ligand, organism-specific biosystemDiverse molecules of host-cell origin may serve as endogenous ligands of Toll-like receptors (TLRs) (Erridge C 2010; Piccinini AM & Midwood KS 2010). These molecules are known as damage-associated mo...
  • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Regulation of toll-like receptor signaling pathway, organism-specific biosystem
    Regulation of toll-like receptor signaling pathway
  • Salmonella infection, organism-specific biosystem (from KEGG)
    Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Salmonella infection, conserved biosystem (from KEGG)
    Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • Toll-like Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Toll-like Receptor Signaling Pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Transfer of LPS from LBP carrier to CD14, organism-specific biosystem (from REACTOME)
    Transfer of LPS from LBP carrier to CD14, organism-specific biosystemLBP delivers LPS from bacteria (or bacterial membrane fragments) to CD14 on the surfaces of phagocytes, where it is recognised by the MD2:TLR4 complex . Thus, LBP is an opsonin and CD14 is an opsonic...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC22233

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipopeptide binding IDA
Inferred from Direct Assay
more info
PubMed 
lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
lipopolysaccharide binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipopolysaccharide binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lipoteichoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
acute-phase response IEP
Inferred from Expression Pattern
more info
PubMed 
acute-phase response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular defense response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to lipoteichoic acid IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
defense response to Gram-negative bacterium ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
detection of molecule of bacterial origin IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response IC
Inferred by Curator
more info
PubMed 
innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
leukocyte chemotaxis involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide transport IDA
Inferred from Direct Assay
more info
PubMed 
lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
macromolecule localization IDA
Inferred from Direct Assay
more info
PubMed 
macrophage activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
macrophage activation involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of growth of symbiont in host IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
opsonization IC
Inferred by Curator
more info
PubMed 
opsonization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of chemokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytolysis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macrophage activation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of respiratory burst involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
toll-like receptor 4 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lipopolysaccharide-binding protein
Names
BPI fold containing family D, member 2
LPS-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034239.1 RefSeqGene

    Range
    5001..35601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004139.5NP_004130.2  lipopolysaccharide-binding protein precursor

    See identical proteins and their annotated locations for NP_004130.2

    Status: REVIEWED

    Source sequence(s)
    AF105067, AL391095, BC022256
    Consensus CDS
    CCDS13304.1
    UniProtKB/Swiss-Prot
    P18428
    UniProtKB/TrEMBL
    Q8TCF0
    Related
    ENSP00000217407.2, ENST00000217407.2
    Conserved Domains (2) summary
    smart00328
    Location:33256
    BPI1; BPI/LBP/CETP N-terminal domain
    pfam02886
    Location:241478
    LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    38346411..38377011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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