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KCNMA1 potassium calcium-activated channel subfamily M alpha 1 [ Homo sapiens (human) ]

Gene ID: 3778, updated on 15-Apr-2019

Summary

Official Symbol
KCNMA1provided by HGNC
Official Full Name
potassium calcium-activated channel subfamily M alpha 1provided by HGNC
Primary source
HGNC:HGNC:6284
See related
Ensembl:ENSG00000156113 MIM:600150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLO; BKTM; SLO1; hSlo; MaxiK; PNKD3; SAKCA; mSLO1; CADEDS; KCa1.1; SLO-ALPHA; bA205K10.1
Summary
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in endometrium (RPKM 7.1), brain (RPKM 4.7) and 17 other tissues See more
Orthologs

Genomic context

See KCNMA1 in Genome Data Viewer
Location:
10q22.3
Exon count:
46
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (76869601..77637969, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (78629359..79397577, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs748 Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 8 Neighboring gene KCNMA1 antisense RNA 1 Neighboring gene KCNMA1 antisense RNA 2 Neighboring gene KCNMA1 antisense RNA 3 Neighboring gene uncharacterized LOC105378369 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 15 Neighboring gene RNA, 5S ribosomal pseudogene 321 Neighboring gene uncharacterized LOC105378372 Neighboring gene zinc finger protein 532 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
CEREBELLAR ATROPHY, DEVELOPMENTAL DELAY, AND SEIZURES
MedGen: C4539985 OMIM: 617643 GeneReviews: Not available
not available
Generalized epilepsy and paroxysmal dyskinesia
MedGen: C1836173 OMIM: 609446 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
NHGRI GWA Catalog
Genome wide association study identifies KCNMA1 contributing to human obesity.
NHGRI GWA Catalog
Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
NHGRI GWA Catalog
Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Ca2+ activated K+ channels, organism-specific biosystem (from REACTOME)
    Ca2+ activated K+ channels, organism-specific biosystemCa2+ activated potassium channels are expressed in neuronal and non-neuronal tissue such as smooth muscle, epithelial cell and sensory cells. Ca2+ activated potassium channels are activated when the ...
  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Insulin secretion, organism-specific biosystem (from KEGG)
    Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Nitric oxide stimulates guanylate cyclase, organism-specific biosystem (from REACTOME)
    Nitric oxide stimulates guanylate cyclase, organism-specific biosystemNitric Oxide (NO) inhibits smooth muscle cell proliferation and migration, oxidation of low-density lipoproteins, and platelet aggregation and adhesion. It can stimulate vasodilatation of the endothe...
  • Pancreatic secretion, organism-specific biosystem (from KEGG)
    Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Pancreatic secretion, conserved biosystem (from KEGG)
    Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Platelet homeostasis, organism-specific biosystem (from REACTOME)
    Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • Renin secretion, organism-specific biosystem (from KEGG)
    Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin secretion, conserved biosystem (from KEGG)
    Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
    Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
    Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • cGMP effects, organism-specific biosystem (from REACTOME)
    cGMP effects, organism-specific biosystemCyclic guanosine monophosphate (cGMP) is an important secondary messenger synthesized by guanylate cyclases. cGMP has effects on phosphodiesterases (PDE), ion-gated channels, and the cGMP-dependent p...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71881, DKFZp686K1437

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
large conductance calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
large conductance calcium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
large conductance calcium-activated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular potassium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
micturition IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell volume IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
relaxation of vascular smooth muscle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
response to carbon monoxide IDA
Inferred from Direct Assay
more info
PubMed 
response to carbon monoxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
response to osmotic stress IDA
Inferred from Direct Assay
more info
PubMed 
smooth muscle contraction involved in micturition IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcium-activated potassium channel subunit alpha-1; uncharacterized protein
Names
BK channel alpha subunit
BKCA alpha subunit
big potassium channel alpha subunit
calcium-activated potassium channel, subfamily M subunit alpha-1
k(VCA)alpha
maxi-K channel HSLO
potassium channel, calcium activated large conductance subfamily M alpha, member 1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
slo homolog
slowpoke homolog
stretch-activated Kca channel

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012270.1 RefSeqGene

    Range
    5001..773219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014797.2NP_001014797.1  calcium-activated potassium channel subunit alpha-1 isoform a

    See identical proteins and their annotated locations for NP_001014797.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AB209488, AC011439, BC024965, U09384
    UniProtKB/Swiss-Prot
    Q12791
    UniProtKB/TrEMBL
    Q59FH2
    Related
    ENSP00000473714.2, ENST00000604624.6
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001161352.2NP_001154824.1  calcium-activated potassium channel subunit alpha-1 isoform c

    See identical proteins and their annotated locations for NP_001154824.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (c) contains a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AB113382, AC011439, BC024965, BQ574058, U11058
    Consensus CDS
    CCDS60569.1
    UniProtKB/Swiss-Prot
    Q12791
    Related
    ENSP00000286628.8, ENST00000286628.14
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_001161353.1NP_001154825.1  calcium-activated potassium channel subunit alpha-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (d) contains a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AB113575, AC011439, BC024965, BQ574058, U11058
    Consensus CDS
    CCDS53545.1
    UniProtKB/Swiss-Prot
    Q12791
    Related
    ENSP00000485867.1, ENST00000626620.3
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_001271518.1NP_001258447.1  calcium-activated potassium channel subunit alpha-1 isoform e

    See identical proteins and their annotated locations for NP_001258447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) omits an in-frame coding exon. The resulting isoform (e) is shorter compared to isoform a.
    Source sequence(s)
    AB209488, AB524033, AC011439, BC024965, BC137115
    Consensus CDS
    CCDS86106.1
    UniProtKB/Swiss-Prot
    Q12791
    UniProtKB/TrEMBL
    D5MRH1, Q59FH2
    Related
    ENSP00000491555.1, ENST00000640807.1
    Conserved Domains (4) summary
    pfam00520
    Location:156342
    Ion_trans; Ion transport protein
    pfam03493
    Location:491579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:252337
    Ion_trans_2; Ion channel
    cl21454
    Location:356469
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. NM_001271519.1NP_001258448.1  calcium-activated potassium channel subunit alpha-1 isoform f

    See identical proteins and their annotated locations for NP_001258448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (f) contains a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC011439, AC021032, AK024857, BC024965, BC144496
    Consensus CDS
    CCDS86116.1
    UniProtKB/TrEMBL
    B7ZMF5
    Related
    ENSP00000491732.1, ENST00000639406.1
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. NM_001271520.1NP_001258449.1  uncharacterized protein isoform short1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is a two-exon transcript with a distinct 3'UTR compared to variant 1. The predicted protein (short1) has a distinct C-terminus and is significantly shorter than isoform a. It is unknown if this protein is stable or has any function.
    Source sequence(s)
    AL731556, BC009695, BC024965
    Consensus CDS
    CCDS73156.1
    UniProtKB/TrEMBL
    A0A087WZL8
    Related
    ENSP00000482747.1, ENST00000618048.2
  7. NM_001271521.1NP_001258450.1  uncharacterized protein isoform short2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) is a two-exon transcript with a distinct 3'UTR compared to variant 1. The predicted protein (short2) has a distinct C-terminus and is significantly shorter than isoform a. It is unknown if this protein is stable or has any function.
    Source sequence(s)
    BC009695, BC024965
    Consensus CDS
    CCDS60572.1
    UniProtKB/TrEMBL
    S4R453
    Related
    ENSP00000475086.1, ENST00000481070.1
  8. NM_001271522.1NP_001258451.1  uncharacterized protein isoform short3

    See identical proteins and their annotated locations for NP_001258451.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) is a two-exon transcript with a distinct 3'UTR compared to variant 1. The predicted protein (short3) has a distinct C-terminus and is significantly shorter than isoform a. It is unknown if this protein is stable or has any function.
    Source sequence(s)
    BC024965
    Consensus CDS
    CCDS60571.1
    UniProtKB/Swiss-Prot
    Q12791
    Related
    ENSP00000474686.1, ENST00000480683.2
  9. NM_001322829.1NP_001309758.1  calcium-activated potassium channel subunit alpha-1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
    Related
    ENSP00000490978.1, ENST00000638991.1
  10. NM_001322830.1NP_001309759.1  calcium-activated potassium channel subunit alpha-1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
    Consensus CDS
    CCDS86121.1
    UniProtKB/TrEMBL
    A0A1W2PR56
    Related
    ENSP00000492492.1, ENST00000638223.1
  11. NM_001322832.1NP_001309761.1  calcium-activated potassium channel subunit alpha-1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
    Consensus CDS
    CCDS81481.1
    UniProtKB/TrEMBL
    A0A1W2PQK5
    Related
    ENSP00000492005.1, ENST00000639486.1
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  12. NM_001322835.1NP_001309764.1  calcium-activated potassium channel subunit alpha-1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
    Related
    ENSP00000361498.6, ENST00000372421.10
  13. NM_001322836.1NP_001309765.1  calcium-activated potassium channel subunit alpha-1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
    Consensus CDS
    CCDS86115.1
    UniProtKB/TrEMBL
    A0A1W2PP94
    Related
    ENSP00000491418.1, ENST00000640141.1
  14. NM_001322837.1NP_001309766.1  calcium-activated potassium channel subunit alpha-1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
    Related
    ENSP00000491277.1, ENST00000639370.1
  15. NM_001322838.1NP_001309767.1  calcium-activated potassium channel subunit alpha-1 isoform m

    Status: REVIEWED

    Source sequence(s)
    AC011439, AK310379, AL731575
    Conserved Domains (4) summary
    pfam00520
    Location:30216
    Ion_trans; Ion transport protein
    pfam03493
    Location:365453
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:126211
    Ion_trans_2; Ion channel
    cl21454
    Location:230343
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  16. NM_001322839.1NP_001309768.1  calcium-activated potassium channel subunit alpha-1 isoform short4

    Status: REVIEWED

    Source sequence(s)
    AL731556
  17. NM_002247.3NP_002238.2  calcium-activated potassium channel subunit alpha-1 isoform b

    See identical proteins and their annotated locations for NP_002238.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (b) contains a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC011439, BC024965, BC137115, BQ574058, U11058, U13913
    Consensus CDS
    CCDS7352.1
    UniProtKB/Swiss-Prot
    Q12791
    Related
    ENSP00000286627.5, ENST00000286627.10
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    76869601..77637969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016213.2XP_016871702.1  calcium-activated potassium channel subunit alpha-1 isoform X13

  2. XM_011539775.2XP_011538077.1  calcium-activated potassium channel subunit alpha-1 isoform X7

    Conserved Domains (4) summary
    pfam00520
    Location:254440
    Ion_trans; Ion transport protein
    pfam03493
    Location:589677
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:350435
    Ion_trans_2; Ion channel
    cl21454
    Location:454567
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_017016212.2XP_016871701.1  calcium-activated potassium channel subunit alpha-1 isoform X11

  4. XM_017016211.2XP_016871700.1  calcium-activated potassium channel subunit alpha-1 isoform X10

  5. XM_017016210.2XP_016871699.1  calcium-activated potassium channel subunit alpha-1 isoform X5

  6. XM_011539773.2XP_011538075.1  calcium-activated potassium channel subunit alpha-1 isoform X4

    Conserved Domains (4) summary
    pfam00520
    Location:254440
    Ion_trans; Ion transport protein
    pfam03493
    Location:589677
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:350435
    Ion_trans_2; Ion channel
    cl21454
    Location:454567
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  7. XM_017016208.2XP_016871697.1  calcium-activated potassium channel subunit alpha-1 isoform X2

  8. XM_017016207.2XP_016871696.1  calcium-activated potassium channel subunit alpha-1 isoform X1

  9. XM_017016217.1XP_016871706.1  calcium-activated potassium channel subunit alpha-1 isoform X22

  10. XM_017016222.2XP_016871711.2  calcium-activated potassium channel subunit alpha-1 isoform X42

    Related
    ENSP00000491008.1, ENST00000638306.1
    Conserved Domains (3) summary
    pfam00520
    Location:179387
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  11. XM_024447990.1XP_024303758.1  calcium-activated potassium channel subunit alpha-1 isoform X41

    Related
    ENSP00000491123.1, ENST00000638203.1
    Conserved Domains (3) summary
    pfam00520
    Location:179387
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  12. XM_024447989.1XP_024303757.1  calcium-activated potassium channel subunit alpha-1 isoform X40

    Related
    ENSP00000491981.1, ENST00000638606.1
    Conserved Domains (3) summary
    pfam00520
    Location:179387
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  13. XM_005269796.2XP_005269853.1  calcium-activated potassium channel subunit alpha-1 isoform X28

    UniProtKB/TrEMBL
    A0A1W2PSD3
    Related
    ENSP00000492806.1, ENST00000639601.1
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  14. XM_005269787.4XP_005269844.1  calcium-activated potassium channel subunit alpha-1 isoform X37

    UniProtKB/TrEMBL
    A0A1W2PPY5
    Related
    ENSP00000491673.1, ENST00000639090.1
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  15. XM_005269776.4XP_005269833.1  calcium-activated potassium channel subunit alpha-1 isoform X35

    Related
    ENSP00000361480.4, ENST00000372403.9
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  16. XM_005269792.2XP_005269849.1  calcium-activated potassium channel subunit alpha-1 isoform X25

    Related
    ENSP00000385806.3, ENST00000404857.6
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  17. XM_024447984.1XP_024303752.1  calcium-activated potassium channel subunit alpha-1 isoform X19

    Related
    ENSP00000396608.2, ENST00000457953.6
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  18. XM_005269781.2XP_005269838.1  calcium-activated potassium channel subunit alpha-1 isoform X18

    UniProtKB/TrEMBL
    A0A1W2PR62
    Related
    ENSP00000492075.1, ENST00000639544.1
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  19. XM_024447987.1XP_024303755.1  calcium-activated potassium channel subunit alpha-1 isoform X36

    Related
    ENSP00000385717.3, ENST00000404771.8
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  20. XM_011539785.2XP_011538087.1  calcium-activated potassium channel subunit alpha-1 isoform X38

    Related
    ENSP00000492718.1, ENST00000639205.1
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  21. XM_024447985.1XP_024303753.1  calcium-activated potassium channel subunit alpha-1 isoform X27

    Related
    ENSP00000491927.1, ENST00000639489.1
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  22. XM_024447988.1XP_024303756.1  calcium-activated potassium channel subunit alpha-1 isoform X39

    Related
    ENSP00000492510.1, ENST00000640182.1
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  23. XM_005269789.2XP_005269846.1  calcium-activated potassium channel subunit alpha-1 isoform X24

    UniProtKB/TrEMBL
    Q5SVJ7
    Related
    ENSP00000361520.2, ENST00000372443.6
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  24. XM_005269778.2XP_005269835.1  calcium-activated potassium channel subunit alpha-1 isoform X16

    UniProtKB/TrEMBL
    A0A1W2PRN5
    Related
    ENSP00000492414.1, ENST00000638848.1
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  25. XM_011539780.2XP_011538082.1  calcium-activated potassium channel subunit alpha-1 isoform X15

    Related
    ENSP00000491539.1, ENST00000640934.1
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  26. XM_017016223.1XP_016871712.1  calcium-activated potassium channel subunit alpha-1 isoform X43

    Conserved Domains (4) summary
    pfam00520
    Location:30216
    Ion_trans; Ion transport protein
    pfam03493
    Location:365453
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:126211
    Ion_trans_2; Ion channel
    cl21454
    Location:230343
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  27. XM_011539781.3XP_011538083.1  calcium-activated potassium channel subunit alpha-1 isoform X20

    Conserved Domains (4) summary
    pfam00520
    Location:254440
    Ion_trans; Ion transport protein
    pfam03493
    Location:589677
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:350435
    Ion_trans_2; Ion channel
    cl21454
    Location:454567
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  28. XM_017016214.2XP_016871703.1  calcium-activated potassium channel subunit alpha-1 isoform X14

  29. XM_011539779.2XP_011538081.1  calcium-activated potassium channel subunit alpha-1 isoform X12

    Conserved Domains (4) summary
    pfam00520
    Location:254440
    Ion_trans; Ion transport protein
    pfam03493
    Location:589677
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:350435
    Ion_trans_2; Ion channel
    cl21454
    Location:454567
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  30. XM_017016209.2XP_016871698.1  calcium-activated potassium channel subunit alpha-1 isoform X3

  31. XM_011539774.2XP_011538076.1  calcium-activated potassium channel subunit alpha-1 isoform X6

    Conserved Domains (4) summary
    pfam00520
    Location:254440
    Ion_trans; Ion transport protein
    pfam03493
    Location:589677
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:350435
    Ion_trans_2; Ion channel
    cl21454
    Location:454567
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  32. XM_011539782.2XP_011538084.1  calcium-activated potassium channel subunit alpha-1 isoform X21

    Related
    ENSP00000491840.1, ENST00000638514.1
    Conserved Domains (4) summary
    pfam00520
    Location:254440
    Ion_trans; Ion transport protein
    pfam03493
    Location:589677
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:350435
    Ion_trans_2; Ion channel
    cl21454
    Location:454567
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  33. XM_006717826.2XP_006717889.1  calcium-activated potassium channel subunit alpha-1 isoform X26

    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  34. XM_011539778.2XP_011538080.1  calcium-activated potassium channel subunit alpha-1 isoform X9

    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  35. XM_011539783.2XP_011538085.1  calcium-activated potassium channel subunit alpha-1 isoform X23

    Related
    ENSP00000490982.1, ENST00000639823.1
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  36. XM_017016215.2XP_016871704.1  calcium-activated potassium channel subunit alpha-1 isoform X17

    Related
    ENSP00000491300.1, ENST00000638283.1
  37. XM_011539777.2XP_011538079.1  calcium-activated potassium channel subunit alpha-1 isoform X8

    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  38. XM_024447986.1XP_024303754.1  calcium-activated potassium channel subunit alpha-1 isoform X30

    Related
    ENSP00000491166.1, ENST00000638754.1
    Conserved Domains (3) summary
    pfam00520
    Location:21238
    Ion_trans; Ion transport protein
    pfam03493
    Location:387475
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:252365
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  39. XM_017016218.1XP_016871707.1  calcium-activated potassium channel subunit alpha-1 isoform X29

    Related
    ENSP00000492519.1, ENST00000639730.1
  40. XM_017016219.2XP_016871708.1  calcium-activated potassium channel subunit alpha-1 isoform X31

  41. XM_011539784.2XP_011538086.1  calcium-activated potassium channel subunit alpha-1 isoform X32

    Conserved Domains (4) summary
    pfam00520
    Location:254440
    Ion_trans; Ion transport protein
    pfam03493
    Location:589677
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:350435
    Ion_trans_2; Ion channel
    cl21454
    Location:454567
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  42. XM_017016220.2XP_016871709.1  calcium-activated potassium channel subunit alpha-1 isoform X33

  43. XM_017016221.2XP_016871710.1  calcium-activated potassium channel subunit alpha-1 isoform X34

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