KCNK2 potassium two pore domain channel subfamily K member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KCNK2provided by HGNC
Official Full Name: potassium two pore domain channel subfamily K member 2provided by HGNC
Primary source: HGNC:HGNC:6277
See related: Ensembl:ENSG00000082482 MIM:603219; AllianceGenome:HGNC:6277
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TREK; TPKC1; TREK1; K2p2.1; TREK-1; hTREK-1c; hTREK-1e
Summary: This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in adrenal (RPKM 18.5), thyroid (RPKM 2.6) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 1q41

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (215005542..215237090)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (214245543..214477417)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (215178885..215410433)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prolonged stretching of rat uteri causes hypoxia and inhibits contractility via potassium channel TREK1.
Title: Prolonged stretching of rat uteri causes hypoxia and inhibits contractility via potassium channel TREK1.
miR-132-3p promotes heat stimulation-induced esophageal squamous cell carcinoma tumorigenesis by targeting KCNK2.
Title: miR-132-3p promotes heat stimulation-induced esophageal squamous cell carcinoma tumorigenesis by targeting KCNK2.
Activation of TREK-1 (K2P2.1) potassium channels protects against influenza A-induced lung injury.
Title: Activation of TREK-1 (K(2P)2.1) potassium channels protects against influenza A-induced lung injury.
Involvement of TREK1 channels in the proliferation of human hepatic stellate LX-2 cells.
Title: Involvement of TREK1 channels in the proliferation of human hepatic stellate LX-2 cells.
Intracellular activation of full-length human TREK-1 channel by hypoxia, high lactate, and low pH denotes polymodal integration by ischemic factors.
Title: Intracellular activation of full-length human TREK-1 channel by hypoxia, high lactate, and low pH denotes polymodal integration by ischemic factors.
Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.
Title: Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.
A regulatory domain in the K2P2.1 (TREK-1) carboxyl-terminal allows for channel activation by monoterpenes.
Title: A regulatory domain in the K(2P)2.1 (TREK-1) carboxyl-terminal allows for channel activation by monoterpenes.
Astrocytic AEG-1 regulates expression of TREK-1 under acute hypoxia.
Title: Astrocytic AEG-1 regulates expression of TREK-1 under acute hypoxia.
The activity of TREK-1 has a key role for the correct functioning of the alveolar epithelium.
Title: Involvement of the TREK-1 channel in human alveolar cell membrane potential and its regulation by inhibitors of the chloride current.
The frequencies of rs758937019-CT genotype (P = 0.0016) and rs758937019-T allele (P = 0.0022) were significantly higher in the group with overactive lower urinary tract symptoms
Title: Association of genetic polymorphisms in the pore domains of mechano-gated TREK-1 channel with overactive lower urinary tract symptoms in humans.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:481280

D1S2475 (e-PCR)
- UniSTS:31248

D1S1602 (e-PCR)
- UniSTS:46648

AL010056 (e-PCR)
- UniSTS:75340

AL034226 (e-PCR)
- UniSTS:94044

D1S2141 (e-PCR), detects polymorphism
- UniSTS:11869

D1S1666 (e-PCR)
- UniSTS:40287

AL033927 (e-PCR)
- UniSTS:93810

WI-15954 (e-PCR)
- UniSTS:7309

NoName (e-PCR)
- UniSTS:483247

KCNK2_2527 (e-PCR)
- UniSTS:471472

SHGC-76351 (e-PCR)
- UniSTS:49379

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables ligand-gated channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables mechanosensitive potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables mechanosensitive potassium channel activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium ion leak channel activity	IEA Inferred from Electronic Annotation more info
enables potassium ion leak channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cardiac ventricle development	IEA Inferred from Electronic Annotation more info
involved_in cellular response to arachidonate	IEA Inferred from Electronic Annotation more info
involved_in cellular response to arachidonate	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission, postsynaptic	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cochlea development	IEA Inferred from Electronic Annotation more info
involved_in detection of mechanical stimulus involved in sensory perception of touch	IEA Inferred from Electronic Annotation more info
involved_in detection of mechanical stimulus involved in sensory perception of touch	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutamate secretion	IEA Inferred from Electronic Annotation more info
involved_in glutamate secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in memory	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in neuronal action potential	IEA Inferred from Electronic Annotation more info
involved_in neuronal action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic transmission, GABAergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to axon injury	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in astrocyte projection	IEA Inferred from Electronic Annotation more info
located_in astrocyte projection	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in calyx of Held	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in node of Ranvier	IEA Inferred from Electronic Annotation more info
located_in node of Ranvier	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: potassium channel subfamily K member 2

Names: K2P2.1 potassium channel; TREK-1 K(+) channel subunit; TWIK-related potassium channel 1; outward rectifying potassium channel protein TREK-1; potassium channel, two pore domain subfamily K, member 2; potassium inwardly-rectifying channel, subfamily K, member 2; tandem-pore-domain potassium channel TREK-1; two pore domain potassium channel TREK-1; two pore domain potassium channel TREK1; two pore potassium channel TPKC1; two-pore potassium channel 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017424.3 → NP_001017424.1 potassium channel subfamily K member 2 isoform a

See identical proteins and their annotated locations for NP_001017424.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC092804, AK123409, AL583830, AU280191, BC069462, CD625291, CD625297, DA475072

Consensus CDS

CCDS41466.1

UniProtKB/TrEMBL

U3N834

Related

ENSP00000375765.2, ENST00000391895.6

Conserved Domains (1) summary

pfam07885
Location:137 → 192

Ion_trans_2; Ion channel
NM_001017425.3 → NP_001017425.2 potassium channel subfamily K member 2 isoform c

See identical proteins and their annotated locations for NP_001017425.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and beginning of the coding region compared to variant 1. The resulting isoform (c) is slightly shorter and has a distinct N-terminus compared to isoform a.

Source sequence(s)

AC092804, AC099675, AK123409, BC069462, DR001358, EF165334

Consensus CDS

CCDS41467.1

UniProtKB/Swiss-Prot

A1Z1V3, A8K618, B2RCS4, B7ZL56, D3DTA5, O95069, Q5DP47, Q5DP48, Q9NRT2, Q9UNE3

Related

ENSP00000394033.2, ENST00000444842.7

Conserved Domains (1) summary

pfam07885
Location:142 → 196

Ion_trans_2; Ion channel
NM_014217.4 → NP_055032.1 potassium channel subfamily K member 2 isoform b

See identical proteins and their annotated locations for NP_055032.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and beginning of the open reading frame compared to variant 1. The resulting isoform (b) is slightly shorter and has a distinct N-terminus compared to isoform a.

Source sequence(s)

AC092804, AC099675, AK123409, BC069462, BC101693, DR001358

Consensus CDS

CCDS31024.1

UniProtKB/TrEMBL

U3N6F0

Related

ENSP00000375764.2, ENST00000391894.6

Conserved Domains (1) summary

pfam07885
Location:127 → 181

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

215005542..215237090

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017001249.2 → XP_016856738.1 potassium channel subfamily K member 2 isoform X1

Conserved Domains (1) summary

pfam07885
Location:127 → 182

Ion_trans_2; Ion channel
XM_011509524.3 → XP_011507826.1 potassium channel subfamily K member 2 isoform X2

See identical proteins and their annotated locations for XP_011507826.1

Conserved Domains (1) summary

pfam07885
Location:86 → 140

Ion_trans_2; Ion channel
XM_011509522.3 → XP_011507824.1 potassium channel subfamily K member 2 isoform X2

See identical proteins and their annotated locations for XP_011507824.1

Conserved Domains (1) summary

pfam07885
Location:86 → 140

Ion_trans_2; Ion channel
XM_047419881.1 → XP_047275837.1 potassium channel subfamily K member 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

214245543..214477417

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054336482.1 → XP_054192457.1 potassium channel subfamily K member 2 isoform X1
XM_054336483.1 → XP_054192458.1 potassium channel subfamily K member 2 isoform X2